DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and Erap1

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	906	Identity:	310/906 - (34%)
Similarity:	484/906 - (53%)	Gaps:	62/906 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPL 207
            |||:.:.|..|.|.:..:|....:.|...:.:....|.:.|.:|...|.:|...::|  .:|..|
Mouse    42 RLPEYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQISKATLRR--GAGEML 104

  Fly   208 KDITPTLTFAHPEFEYWVTEFEQPLEAGN-YSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSII 271
            .: .|.....:|..|.......|||.||: |::::::..:|.:...|.|:|:|..: :...|.:.
Mouse   105 SE-EPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQ-EGEMRILA 167

  Fly   272 STKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHV-LSNMP-VASEYVDGDITEVTFAETV 334
            :|:||||.||.||||||||||||.|:|.:.|   |..|: :|||| |.|..|...:.|..|..||
Mouse   168 ATQFEPTAARMAFPCFDEPALKASFSIKIKR---DPRHLAISNMPLVKSVNVAEGLIEDHFDITV 229

  Fly   335 PMSTYLAAFVVSDFQ-YKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYAL 398
            .|||||.||::|||: ..:.|..|..::  |||.|.::.:..||||.|..::.:|.:|||:.|.|
Mouse   230 KMSTYLVAFIISDFKSVSKMTKSGVKVS--VYAVPDKINQADYALDAAVTLLEFYEDYFNIPYPL 292

  Fly   399 PKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNW 463
            ||.||.|||||.|||||||||.|:||::||||:..||:.:|..:.::|:||||||||||||||.|
Mouse   293 PKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWFGNLVTMEW 357

  Fly   464 WNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITEY 528
            |||||||||||.|:|:..|...|||..:::.| ..:....:.:||..:|||:...:|:||:|.|.
Mouse   358 WNDLWLNEGFAKFMEFVSVTVTHPELKVEDYF-FGKCFNAMEVDALNSSHPVSTPVENPAQIREM 421

  Fly   529 FDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTED------YLTAVEEEEGLE-- 585
            ||.::|.|||.::.||.:.:..:..:....:||.::.|.....||      ::...:..:.::
Mouse   422 FDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGF 486

  Fly   586 -----------------FDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEA 633
                             .|||.:|.|||.|.|.|::.:..||....:.|:.::...:.:
Mouse   487 CSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITITVSGRNVHMKQEHYMKGSERF------ 545

  Fly   634 SSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAE 698
            ....|.|.:|:|:.:|.:..||..:.....:  .:.|||...|||.|....|||.|:|..:.||.
Mouse   546 PETGYLWHVPLTFITSKSDSVQRFLLKTKTD--VLILPEAVQWIKFNVGMNGYYIVHYADDGWAS 608

  Fly   699 LISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLR 763
            |...||.:..|.|:.|||.|:|:|..|.:..:|:...||||..||::|.:.:|.....:.|..:.
Mouse   609 LSGLLKEAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQALNELIPMY 673

  Fly   764 NRVYYTDLY---TNYTTYARKLLTPIVEKVTFTVAADHLENRLRIKVLSSACSLGHESSLQQAVT 825
            ..:...|:.   |.:..:..|||..:::|.|:|......|..||.::|..||...::..:|:|..
Mouse   674 KLMEKRDMIEVETQFKDFLLKLLKDLIDKQTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAER 738

  Fly   826 LFNQWLASPETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVP 889
            .|.:|.:|......| |:...|:..|.|  ||| .||.::..|.....:.||.::...|...:.|
Mouse   739 YFREWKSSNGNMSIPIDVTLAVFAVGAQ--NTE-GWDFLYSKYQSSLSSTEKSQIEFSLCTSKDP 800

  Fly   890 WLLQRYINWAWDES----NVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLG 950
            ..||    |..|:|    .::.|::..:|..|..||||..|.|.::||||.|||.:|.:...::.
Mouse   801 EKLQ----WLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIA 861

  Fly   951 RLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            .::...|.:|||..:|||::.||:...|.|:.....||.:|.::.||:|:..|..::..||
Mouse   862 HMVMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTIETIEENIRWMDKNFDKIRLWL 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	168/397 (42%)
		M1_APN_2	151..602	CDD:189008	183/479 (38%)
		ERAP1_C	677..992	CDD:288671	101/322 (31%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	180/474 (38%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	103/325 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820