DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and npepps

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	901	Identity:	304/901 - (33%)
Similarity:	474/901 - (52%)	Gaps:	60/901 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPL 207
            |||..::|..|.|.|:|||....:.|.:..:::|...       ..|:.::..::..:..|.||.
Frog     9 RLPTDVRPVNYGLCLKPDLIDFTFEGKLEATVEVQNA-------TNQIVMNCADIDIITASYAPE 66

  Fly   208 KD--ITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            .|  |..|......|.|.....|...|:.|...|.::|.|.|.|::.|.|:|.|. ......|..
Frog    67 GDEEIHATGFNYQNEDEKVTLSFPSTLQKGAGMLKIDFVGELNDKMKGFYRSKYA-TATGEVRYA 130

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASE--YVDGD-ITEVTFAE 332
            ..|:||.|.||:||||:||||:||.|.:.:..|.  :...||||.:...  |.|.: :.||.||.
Frog   131 AVTQFEATDARRAFPCWDEPAIKATFDVILIVPK--DRVALSNMNLIDRKPYPDDENLVEVKFAR 193

  Fly   333 TVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYA 397
            |..|||||.||||.::.:.||. ....:.::||.|..:.|:.::||:.||..:.:|.:||||.|.
Frog   194 TPIMSTYLVAFVVGEYDFVETR-SSDGVLVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYP 257

  Fly   398 LPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMN 462
            |||:||:||.||.:||||||||||:||||||.|...|.|.::|.||:||.||||||||||||||.
Frog   258 LPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTME 322

  Fly   463 WWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITE 527
            ||..|||||||||::||..|....||:|:..|||..:......:||...||||..|:..|:|:.|
Frog   323 WWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALENSHPIEVSVGHPSEVDE 387

  Fly   528 YFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQIM 592
            .||.|:|||||:::|||.:.:|:|..|....:||.:.....|.|||...::|:..|.  .:..:|
Frog   388 IFDAISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATEDLWESLEQASGK--PIAAVM 450

  Fly   593 QTWTEQMGLPVVEVE----KSGSTYKLTQKRFLA----NEDDYAAEAEASSFNYRWSIPITYTSS 649
            .|||:|||.|::.||    :.....||:||:|.|    |.||          :|:|.:||:..:|
Frog   451 NTWTKQMGFPLICVESEQKEDSVVLKLSQKKFCASGAPNSDD----------SYQWMVPISICTS 505

  Fly   650 INSEVQSLIFNHNDNEATITL----PEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETF 710
            .:....::....:..|.|:.|    |.:  |:|:|...||:||..|.:.....|:..:::.  :.
Frog   506 ESPASATVKILMDKPEMTVVLEGVKPHQ--WVKLNPGTVGFYRTQYSTTMLESLLPGIRDL--SL 566

  Fly   711 STADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNY 775
            ...||..|.||..:||.||.:|.:..|.::....:|.:|..||..:..|..|...:.:||.:...
Frog   567 QPVDRLGLQNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFHEEI 631

  Fly   776 TTYARKLLTPIVEKVTF--TVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRP 838
            ..:.|.:.:||.:::.:  .....||:..||..||......||:.:|::|...|.:.:......
Frog   632 QCFVRDVFSPIGQRLGWDPKPGEGHLDALLRGLVLGKLGKAGHQPTLEEARRRFKEHVDGRNVL- 695

  Fly   839 NPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDES 903
            :.|:|..||...|:. ...:..:.:.||:......:||.::...|.|:....|:::.::::..|
Frog   696 SADLRSPVYVTVLKH-GDNSTLETMMKLHKQADMQEEKNRIERVLGAIAEQDLIKKVLSFSLSE- 758

  Fly   904 NVRRQDYFTLLGYIS-TNPVGQSLVWDYVRENWEKLVDRF--GINERTLGRLIPTITARFSTETK 965
            :||.||...::|.:: .:.:|:...|::|::|||:|.:|:  |.   .:.|||......|:::..
Frog   759 DVRPQDTVCVIGGVAGGSKLGRKCAWNFVKDNWEELYNRYQGGF---LISRLIKLSLDGFASDKM 820

  Fly   966 LEEMQQFFAKYPEAGAGTAAR--QQALEAVKANIKWLAANKAQVGEWLANYVQQSS 1019
            ..|::.||..:|   |.:|.|  ||..|.:..|..||..:...:..:|......||
Frog   821 AAEIKAFFDAHP---APSAERTVQQCCENILLNAGWLKRDAEAIHHYLLQRKPSSS 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	170/398 (43%)
		M1_APN_2	151..602	CDD:189008	190/455 (42%)
		ERAP1_C	677..992	CDD:288671	81/321 (25%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	170/398 (43%)
		M1_APN_2	17..460	CDD:189008	190/455 (42%)
		ERAP1_C	535..846	CDD:288671	81/321 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010