DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Enpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	888	Identity:	366/888 - (41%)
Similarity:	535/888 - (60%)	Gaps:	43/888 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 FRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTV-EVKRLDESGA 205
            ||||..|:|..|.|.::..:|...|:|.:|||:.:.:....:.:|:::..::.: |::|......
  Rat    83 FRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRITKLPELRRPSGEQV 147

  Fly   206 PLKDITPTLTFAHPEFEYWVTEFEQPLEAGN----YSLLLNFTGSLVDRITGMYQSSYLDKLKNR 266
            |::     ..|.:.:.||.|.:.|:.|.|.:    |.|.:.|.|.|...:.|.|:::|.:  ..:
  Rat   148 PIR-----RCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTE--DGQ 205

  Fly   267 SRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPV-ASEYVDGDITEVTF 330
            ::||.:|..|||.||::|||||||..||.:.|::..|.  ||..|||||| ..|.:|.|..:.||
  Rat   206 TKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPK--EYSALSNMPVEKEETLDNDWKKTTF 268

  Fly   331 AETVPMSTYLAAFVVSDFQYKETTVEGTSIA---LKVYAPPAQVEKTQYALDTAAGVMAYYINYF 392
            .::|||||||..|.|..|    |:::.||.:   |.||..|.|.:..:||.:....|..::.:||
  Rat   269 MKSVPMSTYLVCFAVHQF----TSIQRTSRSGKPLTVYVQPNQKQTAEYAANITKAVFDFFEDYF 329

  Fly   393 NVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGN 457
            .:.|:|||||.:|||||.:||||||||||:|||.||||...|:|.|:||||.||||||.||||||
  Rat   330 AMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGN 394

  Fly   458 LVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESP 522
            :|||:||:|||||||||||.|:.||.....:|.|.:|.::|::.||...|:.::|||:|.::.:|
  Rat   395 IVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVVVTVSTP 459

  Fly   523 AEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFD 587
            ||||..||.|:|||||:::|||::.:..||.:.....||....:..|.|.|:..::|:....  .
  Rat   460 AEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSLEKASNQ--P 522

  Fly   588 VKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAE--ASSFNYRWSIPITYTSSI 650
            ||::|.|||.|||.|||.|  ||. ..:||||||.   ||.|:..  .|:..|.|:|||.:|.:.
  Rat   523 VKEVMDTWTSQMGYPVVTV--SGK-QNVTQKRFLL---DYKADPSQPPSALGYTWNIPIKWTENG 581

  Fly   651 NSEVQSLIFNHNDNEATITLPEEAS---WIKINTNQVGYYRVNYGSEQWAELISALKNSRETFST 712
            ||   ::...:..|...|||....|   ::|||.:.:|:|||||.:|.|..:...|.::...||:
  Rat   582 NS---NITVYYRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSS 643

  Fly   713 ADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTD--LYTNY 775
            |||:..::||..||.|..|:|..||:|..||.||:|::||....||::.:.: ::..|  ||...
  Rat   644 ADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAVSYIIS-MFEDDRELYPLI 707

  Fly   776 TTYARKLLTPIVEKVTFTVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNP 840
            .||.|..:.||.:.:.:.....|:...||..||..||.:|...:|..|..||..||...|:.| .
  Rat   708 ETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIP-V 771

  Fly   841 DIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNV 905
            ::|.:||.||:|....||||:...:.|...|.||||.||:..|.:|:...||.||:....|.:.:
  Rat   772 NLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKDPNII 836

  Fly   906 RRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQ 970
            :.||.||::.|||.|..|:|:.|::::.||:.||:||.||:|.|||:: ||...|:||.:|.:||
  Rat   837 KTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIV-TIAEPFNTELQLWQMQ 900

  Fly   971 QFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWLAN 1013
            .||||||.||||...|:|.||.||.||:||..|:..:.||..:
  Rat   901 SFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEWFTS 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	174/402 (43%)
		M1_APN_2	151..602	CDD:189008	192/459 (42%)
		ERAP1_C	677..992	CDD:288671	129/316 (41%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	174/402 (43%)
		M1_APN_2	92..537	CDD:189008	192/459 (42%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	129/316 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352479
Domainoid	1	1.000	237	1.000	Domainoid score	I2242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	647	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm44517
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900