DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and RNPEPL1

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_060696.4	Gene:	RNPEPL1 / 57140	HGNCID:	10079	Length:	725	Species:	Homo sapiens

Alignment Length:	636	Identity:	144/636 - (22%)
Similarity:	237/636 - (37%)	Gaps:	167/636 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEP---IAFIPVHVKQ 189
            ||:..||.....| |||    :..:..|.|||  |.:..:|.:.:.|..|.|   ...:..| ..
Human    26 PALDVASASSAQL-FRL----RHLQLGLELRP--EARELAGCLVLELCALRPAPRALVLDAH-PA 82

  Fly   190 LNVSTVEVKRLDESGA------------------------------------------PLKDITP 212
            |.:.:...:|...:.|                                          |..|...
Human    83 LRLHSAAFRRAPAAAAETPCAFAFSAPGPGPAPPPPLPAFPEAPGSEPACCPLAFRVDPFTDYGS 147

  Fly   213 TLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDK--LKNRSRSIISTKF 275
            :||...|.    ..:..||     :.::|.:|.:....|.      :||.  ....::..:.|:.
Human   148 SLTVTLPP----ELQAHQP-----FQVILRYTSTDAPAIW------WLDPELTYGCAKPFVFTQG 197

  Fly   276 EPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITEVTFAETVPMSTYL 340
            .....|..|||||.||:|..::..|..|||  ..||.: ...|.|::.: ....|....|:..||
Human   198 HSVCNRSFFPCFDTPAVKCTYSAVVKAPSG--VQVLMS-ATRSAYMEEE-GVFHFHMEHPVPAYL 258

  Fly   341 AAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVA 405
            .|.|..|.  |...:...|   :|:|.|..:......|..|..............|...:.|:|.
Human   259 VALVAGDL--KPADIGPRS---RVWAEPCLLPTATSKLSGAVEQWLSAAERLYGPYMWGRYDIVF 318

  Fly   406 I-PDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWL 469
            : |.|...|||| ..:||..:::|..:        :.:.|.|.||:||.||||.||...|.::||
Human   319 LPPSFPIVAMEN-PCLTFIISSILESD--------EFLVIDVIHEVAHSWFGNAVTNATWEEMWL 374

  Fly   470 NEGFASFLEYKGVKQMHPE--WDMDNQFVIEELH----------PVLTIDATLASHPIVKSIESP 522
            :||.|::.:.:...:.:..  ..::..|.::.||          ||..:...|  .|.|    :|
Human   375 SEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDSPVSKLQVKL--EPGV----NP 433

  Fly   523 AEITEYFDTITYSKGAALVRMLENLVGE-EKLRNATTRYLVRHIYSTATTEDYL----------- 575
            :.:...|   ||.||...|..|..|.|: ::..:....|:.::.:::...:|.|
Human   434 SHLMNLF---TYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFPELK 495

  Fly   576 -TAVEEEEGLEFDVKQIMQTWTEQMGLPVVEVEKS-GSTYKLTQ------KRFLANEDDYAAEAE 632
             .:|:...||||      :.|....|.|:.|.:.| ||:  ||:      :.:.|...|.|| |.
Human   496 EQSVDCRAGLEF------ERWLNATGPPLAEPDLSQGSS--LTRPVEALFQLWTAEPLDQAA-AS 551

  Fly   633 ASSFNY-RW------------------------SIPITYTS---SINSEVQ 655
            ||:.:. :|                        |:...|:|   |:|:|::
Human   552 ASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIR 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	101/453 (22%)
		M1_APN_2	151..602	CDD:189008	115/523 (22%)
		ERAP1_C	677..992	CDD:288671
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	120/538 (22%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	326..330		2/3 (67%)
		Leuk-A4-hydro_C	560..673	CDD:401171	7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..699
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810