DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and erap1a

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	926	Identity:	325/926 - (35%)
Similarity:	477/926 - (51%)	Gaps:	91/926 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPL 207
            |||:.:||..|.|.:.|:|....::|.:.|.::|.:....|.:|.|.|.||
Zfish    43 RLPEIVKPQHYDLLIHPNLTSLTFTGEVQIQIEVKQDTRAIILHSKNLQVS-------------- 93

  Fly   208 KDITPTLTFAHPEFEYWVTEFEQ-----------PLEAGNYSLLLNFTGSLVDRITGMYQSSYLD 261
            |.:.......|...:..::|||.           ..|.|::.:.|.|..:|.|...|.|:..|..
Zfish    94 KALLLGSRQHHHHQDLQISEFEANEQIALFSEGFTFEKGSHVVHLEFYANLSDSFHGFYKGQYTT 158

  Fly   262 KLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHV-LSNMPV--ASEYVDG 323
            . ....|.:.||:||||:||.|||||||||.||.|||.|.|.|   .|: :||||.  ..|..||
Zfish   159 N-SGEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRES---RHISISNMPKLRTVELADG 219

  Fly   324 DITEVTFAETVPMSTYLAAFVVSDF-QYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAY 387
             |.|..|...|.|||||.||::.|| ...:.:..|..|:  ||..|.::.:.:||||||..::.:
Zfish   220 -ILEDQFDTMVKMSTYLVAFIICDFHSISKKSQHGVEIS--VYTVPEKISQAEYALDTAVTMLDF 281

  Fly   388 YINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAH 452
            |..||::.|.|||.||.|||||.|||||||||.|:||:.||:|...|||.:|..:..|:||||||
Zfish   282 YDEYFDIPYPLPKHDLAAIPDFQSGAMENWGLSTYRESGLLFDPEKSSSSDKLGITKVIAHELAH 346

  Fly   453 QWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVK 517
            |||||||||.||||||||||||.|:||..|...|||..: |.:.:|:....|::|:..:|||:..
Zfish   347 QWFGNLVTMQWWNDLWLNEGFAKFMEYVSVNITHPELQV-NDYFLEKCFTALSVDSLSSSHPVST 410

  Fly   518 SIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTE---DYLTAVE 579
            .:|:||||:|.||.::|.|||.::.||.:.:..|..:.....||.:|.|......   :.||.:.
Zfish   411 PVENPAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLTNIC 475

  Fly   580 EEEGLE---------------------------FDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQ 617
            ..:||:                           .||..||.|||.|.|.|::.||..|....|.|
Zfish   476 TSDGLDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITVEVKGQEVTLKQ 540

  Fly   618 KRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEASWIKINTN 682
            :|||.     .||:..|| ::.|.:|:||.:|.::.||..:.  ........|||:..|||.|.:
Zfish   541 ERFLK-----GAESSNSS-SFLWQVPLTYITSGSNAVQRFLL--KTERDVFYLPEKVEWIKFNVD 597

  Fly   683 QVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQ 747
            ..|||.|:|.|..|..||..|:.:...||:.|||.|::|...|.:..::....||:|..||..|.
Zfish   598 LRGYYIVHYESGGWDCLIKQLRMNHTVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKES 662

  Fly   748 DYVPWSVGTSALATLRNRVYYTD---LYTNYTTYARKLLTPIVEKVTFTVAADHLENRLRIKVLS 809
            :.:|.:.|.|.|..|...:...|   |.....::..||..|::::.:::......|..||..:|.
Zfish   663 EIMPVTQGFSELVPLYKLMEKRDMQELENQLKSHLVKLFQPLIDRQSWSDNGSVSERMLRNYLLL 727

  Fly   810 SACSLGHESSLQQAVTLFNQWLASPETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDA 873
            .||...:.|.:..|..||::|..|......| |:..|||..|   ..|:..||.:.:.|......
Zfish   728 FACVRRYPSCVSTATQLFHKWKESDGKMWLPTDVSLVVYTEG---ARTDDGWDFLLEKYKRSVSP 789

  Fly   874 QEKLKLMNCLT----AVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVREN 934
            .||..:...|:    |.::.|||:|    :.:...::.||..::|..:|.||.|..|.||:::.|
Zfish   790 SEKWMIKAALSYSPLAHKLQWLLER----SSEGEIMKTQDLPSMLISVSKNPKGFKLAWDFLKSN 850

  Fly   935 WEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKY-PEAGAGTAARQQALEAVKANIK 998
            |.|||.:|.:....:.|::..:|.::||:..|:|::.||... .:.|:|..:.|||||.::.||.
Zfish   851 WGKLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSIQQALEKIQQNIL 915

  Fly   999 WLAANKAQVGEWLANY 1014
            |:..|...:..||.::
Zfish   916 WMDRNVPLLKAWLDHH 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	174/408 (43%)
		M1_APN_2	151..602	CDD:189008	192/495 (39%)
		ERAP1_C	677..992	CDD:288671	97/323 (30%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	174/408 (43%)
		M1_APN_2	52..525	CDD:189008	192/494 (39%)
		ERAP1_C	592..909	CDD:288671	97/323 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820