DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and trhde.2

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	893	Identity:	298/893 - (33%)
Similarity:	471/893 - (52%)	Gaps:	37/893 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPL 207
            |||..::|..|.|.|...:|..::||.::|..:.:.....|.:|..:|.:..|.|.. |...|..
Zfish   109 RLPATLRPRHYDLRLTVHMENFSFSGEVNIEFECVNSTKLIVLHSDRLELDKVLVFS-DSKKAGA 172

  Fly   208 KDITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIIS 272
            ..|.....: .|:..|.:....:......|.:.:.||..:...:.|.::|||:  |....|.:..
Zfish   173 MRIQRRFHY-QPKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYM--LNGERRFLAV 234

  Fly   273 TKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGD--ITEVTFAETVP 335
            |:|.||:||:||||||||..||.|.:::...|  .|..||||||.:...|.|  :|. .|:.|..
Zfish   235 TQFSPTHARKAFPCFDEPIYKATFRVSLKHES--SYQSLSNMPVEATTSDEDGWVTN-HFSRTPR 296

  Fly   336 MSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVE--KTQYALDTAAGVMAYYINYFNVSYAL 398
            ||||..|:.|.:|.||| .|....:.:::||.|..::  ...|||.....::.:|.:||.|.|:|
Zfish   297 MSTYYLAWAVCNFTYKE-AVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKVKYSL 360

  Fly   399 PKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNW 463
            |||||:|:|.....|||||||..|.|..:|.|...||...:..:.:||.||:.|||||:|||..|
Zfish   361 PKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVVVHEICHQWFGDLVTPVW 425

  Fly   464 WNDLWLNEGFASFLEYKGVKQMHPEWDMDNQ-FVIEELHPVLTIDATLASHPIVKSIESPAEITE 527
            |.|:||.||||.:.||.|...:.|:|:|:.| |:.:.||.|:.:|...:||||.:.:....:|..
Zfish   426 WEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPISQQVFEATDIDR 490

  Fly   528 YFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDY---LTAVEEEEGLEFDVK 589
            .||.|.|.|||||:|||.|::|:...:.|...||:.|:|..|..:|.   |:...:.||.:.::.
Zfish   491 VFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAMQREGKDINIT 555

  Fly   590 QIMQTWTEQMGLPVVEVEKSGS---TYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITY----T 647
            |:|..||.|||.|||.:.|:.|   :..::|:.|:.:.|......|..:.:::|.||:|.    .
Zfish   556 QVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKSFQWQIPLTLAVGNA 620

  Fly   648 SSINSEVQSLIFNHNDNEA-TITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFS 711
            |.|::|  ::|:..|.:|| .:......:|:..|.||.||:||||....|..||..|..:....|
Zfish   621 SHISTE--TIIWVTNKSEAHRVGHVVGETWLLGNINQTGYFRVNYDLHNWKLLIQQLTRNPTIIS 683

  Fly   712 TADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYT 776
            ..:||.|::|...||.||.|..:|.|.:||||..|.:::||...:.||..|...:..|..::.::
Zfish   684 VGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQETEFLPWHAASRALYQLDKLLDRTLDHSLFS 748

  Fly   777 TYARKLLTPIVEKVTFTVAAD--------HLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLAS 833
            .|..:.:.|...|:.:...:.        :....|:.:|:..|||.|::...:|||:|.:.|::|
Zfish   749 DYVLRQVEPKYHKLGWPATSPDGSLMHSAYQTEELQREVIMLACSFGNKHCHRQAVSLISDWISS 813

  Fly   834 PETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINW 898
            .:.|..|::||:||..|:..:: |..|:.:|..:...:...||..|:..||.....:||.|.:|.
Zfish   814 NKNRIPPNVRDIVYCTGVSLMD-EDVWEFIWMKFHSSTAVSEKKVLLEALTCSDNIFLLNRLLNL 877

  Fly   899 AWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTE 963
            :.....|..||...::.:::.||:|:.|.|.|.||.|:.|..|:|.......:||..:|...:||
Zfish   878 SLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILNSRYGEALFMNSKLISGVTEFLNTE 942

  Fly   964 TKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            .:|.|:::|.  ....|....|..:|:|.|:||:||....:.|..:||
Zfish   943 AELNELKEFI--LTSGGESAPAFARAVEIVQANVKWHILFQEQFYQWL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	145/398 (36%)
		M1_APN_2	151..602	CDD:189008	168/458 (37%)
		ERAP1_C	677..992	CDD:288671	96/322 (30%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	145/398 (36%)
		M1_APN_2	118..568	CDD:189008	168/457 (37%)
		ERAP1_C	649..968	CDD:288671	96/321 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010