DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and anpepa

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	957	Identity:	303/957 - (31%)
Similarity:	493/957 - (51%)	Gaps:	102/957 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 FYTTQV----PTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLE---RKNY 166
            |:..||    ||.....|:.|..|.....|       .|||..:.|..|.:.|:|.|.   ..||
Zfish    32 FFQIQVGNNKPTPPPRPILPTPLPTDLPES-------LRLPDSLIPESYNVFLQPYLYAAITNNY 89

  Fly   167 -------SGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLD-ESGAPLKDITPTLTFAHPEFEY 223
                   :||.::.:...:..:.:.:||..:||:.|||::.| ....|||...   .|.: |..:
Zfish    90 TEQSYLFTGNSTVRVNCTKTSSRVFLHVHNINVTAVEVRKSDTNEKLPLKGYQ---IFKN-ETNF 150

  Fly   224 WVTEFEQPL-EAGNYSLLLNFTGSLVDRITGMYQSSYLDK---LKNRSRSIISTKFEPTYARQAF 284
            .....|..: |.|.|.:...|.|.|::.:||.|.|.|..|   .::..|.:.::..:||.||..|
Zfish   151 LDIHLEVAIKENGTYDIFTEFEGELLEDLTGFYASRYTGKGTDDEDEERFLATSLLQPTDARTVF 215

  Fly   285 PCFDEPALKAQFTITVA-RPSGDEYHVLSNMPVASEYVDGDITEV----------TFAETVPMST 338
            |||||||:||.||||:. ||   |....||       .|||...:          ||..|..||:
Zfish   216 PCFDEPAMKAVFTITIIHRP---EIRARSN-------EDGDPRTIQINGTDWIRTTFKPTKKMSS 270

  Fly   339 YLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVE--KTQYALDTAAGVMAYYINYFNVSYALPKL 401
            ||..|::.|........:||...:.|:.....::  ...|||:|...::::|.|.|.:.|.:.|:
Zfish   271 YLLGFIIYDTHTFSYVSKGTRTKIHVHGRSEAIDAGHADYALETTETILSHYENIFGLRYPMSKI 335

  Fly   402 DLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWND 466
            |.:|:|||...||||||.::::|:.||||:.|:|:.::::|..::|||||||||||||||:||||
Zfish   336 DQIALPDFGVRAMENWGFISYQESGLLYDKETASTFDEEQVTTLIAHELAHQWFGNLVTMSWWND 400

  Fly   467 LWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI---VKSIESPAEITEY 528
            |||.||||:::.||||:.:  .||:.:..|:.|:.....:|:...|||:   ...:::.::|:|.
Zfish   401 LWLKEGFATYMSYKGVEAV--GWDLKDLIVLREIQTAFQMDSLNTSHPLSMNAYDVQTSSQISEL 463

  Fly   529 FDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQIMQ 593
            ||.||||||||::|||...:||.:.......||.:..:.....:|....:..:..::.|  :.|:
Zfish   464 FDDITYSKGAAVLRMLATRMGENEFMKGVKMYLSKFQFENTVPKDLWECLNMDTHIKVD--EFMK 526

  Fly   594 TWTEQMGLPVVE-VEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSL 657
            ||||::|.||:. :..:|.|   :|::||..::        ...:..|.|||.| .::.:.|:..
Zfish   527 TWTEEVGYPVLTIITDTGDT---SQEQFLLKKE--------GGHDSLWHIPIKY-MTLKAGVKEF 579

  Fly   658 IFNHNDNEATITLPE----EASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHL 718
            . |...::....:|:    :.:|:..|.|..|:|||||..|.|..|.:.|:.:.......:|..|
Zfish   580 P-NFFTDKGPDPIPDFKIGKDNWLLANINCTGFYRVNYDEENWNRLTAQLQKNHRIIPLINRGQL 643

  Fly   719 LNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYT------DLYTNYTT 777
            ::||..||.|.:||.::||:|..||.::.:|:||.      :.|:|..::|      ::|.....
Zfish   644 IDDAFNLARAHRLNVTIALNLTKYLINDLEYIPWE------SALKNLDFFTLMFDRSEVYGPIMK 702

  Fly   778 YARKLLTPIVEK-----VTFTVAADHLENRL-RIKVLSSACSLGHESSLQQAVTLFNQWLASPET 836
            |.|.|:||:.|:     :..|:..:...::. ::..::.|||.|....:..|..||:.:  ...:
Zfish   703 YLRNLVTPLYEEYEEYTINGTIPIEKYTDQCNQVNAITVACSNGLPECITMAKDLFSDY--KNGS 765

  Fly   837 RP-NPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAW 900
            .| :|::|..||...:.. ..|..|:.||:.|...:.|.||.||...|:..:..|||.||:.:..
Zfish   766 NPIHPNLRRAVYCSAVAS-GDEDDWEYVWEEYQKATVAAEKDKLRYALSCTKEIWLLNRYLQYTL 829

  Fly   901 DESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETK 965
            :.|.:|:.|..:.:.||:.|..||.|.||::|.:|..:...:|....:||.|:..:|.|||||.:
Zfish   830 EPSKIRKMDMVSTISYIAQNVAGQPLAWDFIRGHWSYITQEYGAGIISLGSLLDVVTKRFSTEVE 894

  Fly   966 LEEMQQFFAKYPEAGAGTAAR--QQALEAVKANIKWLAANKAQVGEW 1010
            |||::|...:..:.....|||  :|.:|...|||.|:..||..|.:|
Zfish   895 LEELKQLQREQIQDDKWIAARALEQVIERTAANIIWVKENKQVVKDW 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	151/424 (36%)
		M1_APN_2	151..602	CDD:189008	166/481 (35%)
		ERAP1_C	677..992	CDD:288671	99/329 (30%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	151/424 (36%)
		M1_APN_2	71..535	CDD:189008	166/481 (35%)
		ERAP1_C	602..923	CDD:288671	99/329 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820