DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	1029	Identity:	331/1029 - (32%)
Similarity:	525/1029 - (51%)	Gaps:	133/1029 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AFCVFLLVLCGFL--LG-ALVYVGKNIAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTKPII 101
            ||.:..|.:...|  || :|:|     |:|.:|.:     :..:|:|:.|:          .|
Zfish    12 AFVLLALAVGSLLTILGLSLIY-----AQEKRRNE-----ENMVNNTVTTL----------AP-- 54

  Fly   102 SVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKN- 165
                    |:|.:|:::         |..|          :|||..:.|..|.:.|.|.|.:.:
Zfish    55 --------YSTSIPSNE---------PWDK----------YRLPDTLLPEYYNITLWPRLTKDDL 92

  Fly   166 ----YSGNISISLQVLEPIAFIPVHVKQLNVST------VEVKRLDESGAP--LKDITPTLTFAH 218
                ::|...::...::....|.:|...||.|.      .|:..|..:.||  ||      |:..
Zfish    93 GMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEKHHAELMGLGGTRAPVILK------TWFQ 151

  Fly   219 PEFEYWVTEFEQPLEAG-NYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQ 282
            .:.|:.|.:..:.|:.| :|.|...|.|.|.|.:.|.|:|.|::  ....:.:.:|:.:||.||.
Zfish   152 DQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGFYRSEYVE--NGVEKVVATTQMQPTAART 214

  Fly   283 AFPCFDEPALKAQFTITVARPSGDEYHVLSN-MPVASEYV---DGDITEVTFAETVPMSTYLAAF 343
            ||||||||::||.|.:|:..|.|..  .|:| |...:|.:   :..:.:..|..|..|||||.||
Zfish   215 AFPCFDEPSMKAVFHLTLIHPPGTV--ALANGMETGTENITIENQQVLQTRFEPTEKMSTYLLAF 277

  Fly   344 VVSDFQYKETTVEGTSIALKVYAPPAQVEKTQ--YALDTAAGVMAYYINYFNVSYALPKLDLVAI 406
            |:|:|...::.:....|.::::.....:|..:  |||:....|:.|..:|:|.:|.|.|.|.:|:
Zfish   278 VISEFPSIQSPLGANKILVRIWGRREAIENGEGDYALNVTFPVLKYLESYYNTTYPLSKSDQIAL 342

  Fly   407 PDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNE 471
            |||.:||||||||||:|||.|.|:...||..:|:.|..|::|||||.||||||||.|||||||||
Zfish   343 PDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITVISHELAHMWFGNLVTMRWWNDLWLNE 407

  Fly   472 GFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVK---SIESPAEITEYFDTIT 533
            ||||::.|.......|.|::....|:::::...|:||.::|||:..   ::.:|.:|.|.||.:|
Zfish   408 GFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALVSSHPLSSREDAVNTPQQIEELFDAVT 472

  Fly   534 YSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDY---LTAVEEEEG---LEFDVKQIM 592
            ||||||::|||...:.|.........||..|.||.....|.   |..|.:.:|   |...:::||
Zfish   473 YSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVYTDLWKKLQEVADSDGNVHLPASIEEIM 537

  Fly   593 QTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSL 657
            ..|..|.|.|||.::.  .|..::|:.||.  |..|...:.|.:||.|.:|||:..:..:..|..
Zfish   538 NRWILQAGFPVVTIDT--HTGSISQQHFLI--DPEAVVNKPSDYNYEWFVPITWMKNGRNMGQHW 598

  Fly   658 IFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDA 722
            :.|.:.:..  .:..|.:||..|.|..|||||||.|:.|..||..|.:..:.....:|..:::||
Zfish   599 LLNKSTSYE--LMKTETNWILANLNVTGYYRVNYDSQNWERLIKQLTSDHQAIPVLNRGQIIDDA 661

  Fly   723 NTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYY------TDLYTNYTTYARK 781
            .|||.|..||.::||....||.:|::|:||.      :.:||..|:      |::......|.|:
Zfish   662 FTLARAKILNITMALRTTQYLSNEKEYIPWE------SAIRNLEYFFLMFDRTEVRGPLEAYLRR 720

  Fly   782 LLTPIVEKVTFTVAAD--------HLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRP 838
            .:.|:..  .|.|...        |::...::..::.||....::..:.....:.||:..|...|
Zfish   721 KVEPLFH--YFKVITSNWTRKPTRHMDQYNQLNAITMACKTRVKACSELTSMWYRQWMKDPNVNP 783

  Fly   839 NP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDE 902
            .| |::.|||...:.....| .||..|.::.:.:.|.|..|||..|:..:.||||.||:::|.|.
Zfish   784 VPSDLKTVVYCNAIAAGGVE-EWDFGWAMFKNSTVAAEAEKLMYGLSCTKEPWLLNRYLHYAIDP 847

  Fly   903 SNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLE 967
            :.:|:||....:.||::|.:||.|.||:.|..|:.:...|.:       ||..|...||||.:|:
Zfish   848 NLIRKQDVTYPIVYIASNVIGQPLAWDFFRAKWQLMTTEFRV-------LILGIVKTFSTEFQLQ 905

  Fly   968 EMQQFFAKYPEAGA--GTAARQQALEAVKANIKWLAANKAQVGEWLANYVQQSS 1019
            ::|:|..:..|:|.  ||.|.:||:|..|||:||::.||.||.:||   :|||:
Zfish   906 QLQRFQEEVAESGVSLGTHAIEQAIEQTKANVKWVSENKVQVMDWL---IQQSA 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	151/416 (36%)
		M1_APN_2	151..602	CDD:189008	170/479 (35%)
		ERAP1_C	677..992	CDD:288671	102/331 (31%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	170/477 (36%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	104/335 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.820