DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and SP1029

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001263065.1	Gene:	SP1029 / 53473	FlyBaseID:	FBgn0263236	Length:	932	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	315/928 - (33%)
Similarity:	480/928 - (51%)	Gaps:	81/928 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 FRLPKQIKPSKYRLHLRPDLERK---NYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDES 203
            :|||..::|.||.|.:...||..   .:||::.|.::.||....:.:|.|.|.:...::......
  Fly    32 YRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHSKNLTIDESQITLRQIG 96

  Fly   204 GAPLKDITPTLTFAHPEFEYWVTEFEQPLEAGN-YSLLLNFTGSLVDRITGMYQSSYLDKLKNRS 267
            |...|:...:.|..:|..::::....|.|.||| |.|.:.|...|..::.|.|:|||.|.:.|.:
  Fly    97 GEGKKENCVSSTAVNPSHDFYILNTCQELLAGNTYELYMPFAADLNRQLEGYYRSSYKDPVANLT 161

  Fly   268 RSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMP--------VASEYVDGD 324
            :.|..|:|||..||.||||||||..||.|.:|:....  :|..:||||        ..::|:
  Fly   162 KWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHK--KYTAISNMPEKETKPHETLADYI--- 221

  Fly   325 ITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYI 389
              ...|.|:|||||||.|:.|:||.:|.:|:..::: .:.:|.|..:::..||......|:.||.
  Fly   222 --WCEFQESVPMSTYLVAYSVNDFSHKPSTLPNSAL-FRTWARPNAIDQCDYAAQFGPKVLQYYE 283

  Fly   390 NYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQW 454
            .:|.:.:.|||:|.:|:|||.:||||||||||:||.||||..:.||..:|||||.||||||||||
  Fly   284 QFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAHSSLADKQRVASVVAHELAHQW 348

  Fly   455 FGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTI---DATLASHPIV 516
            |||||||.||.|||||||||:::...||:.::|||....|   |.|..:|||   ||..:||||.
  Fly   349 FGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQ---ESLSNLLTIFRRDALESSHPIS 410

  Fly   517 KSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATT----EDYLTA 577
            :.|:..:||:|.||.|:|.||:.::||:...:|||..|:....||.:..|..|..    |....|
  Fly   411 RPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQKFSYKNAEQDNLWESLTQA 475

  Fly   578 VEEEEGL--EFDVKQIMQTWTEQMGLPVVEVEK--SGSTYKLTQKRFLANEDDYAAEAEASSFNY 638
            ..:...|  .:|:|.||.:||.|.|.||:.|.:  :..|.||.|:|:|.|..  .|.|      |
  Fly   476 AHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERYLLNTQ--VARA------Y 532

  Fly   639 R---WSIPITYTSSINSEVQSLIFNHNDNEA-------------TI-TLPEEASWIKINTNQVGY 686
            |   |.:|::||:   ..||.  ||:...:|             || .||....|:..||.....
  Fly   533 RGGCWWVPLSYTT---QAVQD--FNNTAPKAWMECGKNGESLPKTIQDLPGPDQWVIFNTQLSTL 592

  Fly   687 YRVNYGSEQWAELISALKNSR-ETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYV 750
            |:|||.::.|..||..|.|.. |.....:||.|::||..||..|:.:|.:|:.||.||:.|::|:
  Fly   593 YKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIEYLQREREYL 657

  Fly   751 PWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTPIVEKV-----TFTVAADHLENRLRIKVLSS 810
            ||......|..:...|..|..:..:..|.:||:.||.|.:     ||:......:..|:..|::.
  Fly   658 PWKSAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDTFSAIPQQDQVLLKTMVVNW 722

  Fly   811 ACSLGHESSLQQAVTLFNQWLAS---PETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDES 871
            ||.......:.||:..:..|.|.   .|..|.| ::|..||...::. .:::.|:.:|..|...:
  Fly   723 ACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIKH-GSDSDWEFLWTRYKKSN 786

  Fly   872 DAQEKLKLMNCLTAVQVPWLLQRYINWAWD-ESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENW 935
            .|.||..::..|...:..||||||:...:| :..:|:||.......::.|.||..|...|..:|.
  Fly   787 VAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQAVAFNEVGFLLAKKYFMDNV 851

  Fly   936 EKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAG-TAARQQALEAVKANIKW 999
            :.:...:....:.:.||:..::.:..|.:...|.:.|.....::..| ..|.||.||.:..|::|
  Fly   852 DFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLKGLEQAIQQTLEIMLTNVQW 916

  Fly  1000 LAANKAQVGEWLANYVQQ 1017
            ...|..|    ::..:||
  Fly   917 KERNYHQ----MSRSIQQ 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	169/408 (41%)
		M1_APN_2	151..602	CDD:189008	188/471 (40%)
		ERAP1_C	677..992	CDD:288671	88/326 (27%)
SP1029	NP_001263065.1	Peptidase_M1	33..431	CDD:279741	169/408 (41%)
		M1_APN_2	43..502	CDD:189008	187/469 (40%)
		ERAP1_C	583..908	CDD:288671	87/325 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462018
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm14800
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	10	9.750