DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Lvrn

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	928	Identity:	279/928 - (30%)
Similarity:	437/928 - (47%)	Gaps:	143/928 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKN-------YSGNISISLQVLEPIAFIPVHVKQLNVSTVEV--- 197
            |||..:.|..|.|.|.|.|:..|       ::|.::|:::.....:.:.:|...||...|||
  Rat    94 RLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFFLNYKQVEVWGP 158

  Fly   198 -----KRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFTGS-LVDRITGMY 255
                 :.......||:::...|     :.:|.|.:..|.|:.| :|.|..:|:|. |.:...|::
  Rat   159 LAPDTRNATVGRVPLENVWFAL-----DMQYVVLDLGQSLDPGSSYELNFDFSGQVLQEGSEGLF 218

  Fly   256 QSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEY 320
            .:.|.|  :::.|::|:|:.|||:||..|||||||||||.|.||:....|  |..|||||...:.
  Rat   219 LNLYTD--EDQLRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPG--YVALSNMPQLGQS 279

  Fly   321 ----VDGDITEVTFAETVP-MSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYA--- 377
                |:|....||...|.| |.|||.|.|:.||.|...|..|..|  :|:|     .|...|
  Rat   280 HRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTERGKEI--RVWA-----RKDDIADGY 337

  Fly   378 LDTAAG----VMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVN 438
            ||.||.    |.::..:.||:||.|||.|::|:|.||:||||||||:.| :.:||.:........
  Rat   338 LDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-DASLLLELDDDLPEK 401

  Fly   439 KQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPV 503
            :..:..:::||:.||||||||||:|||::||||||||:.|.......:|:...:..|.:..||.:
  Rat   402 RAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKVPRNMIFFLTVLHDI 466

  Fly   504 LTIDATLASHPI---VKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHI 565
            |..|.:|.|..:   |::.....||...||..||.|||.:..||...:.:....||...||....
  Rat   467 LEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMAWMLAGFLSQHLFINALKSYLETFS 531

  Fly   566 YSTATTED----YLTAVEEEE--GLEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANE 624
            ||.|..:|    ...|::|:.  .|...||:||.:||.|.|.||:.:..|....|        .|
  Rat   532 YSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITLNASTGVVK--------QE 588

  Fly   625 DDYAAEAEASSF--NYRWSIPITYTSSINSEVQSLIFNHNDNEATITLP------EEASWIKINT 681
            ..|....|..:.  :..|.:||.:..  |...|.|::.   :::::..|      .::.|:.:|.
  Rat   589 PFYLERVENQTLLSHNTWIVPIFWMK--NGITQPLVWL---DKSSMIFPGMKLSDSDSDWVILNF 648

  Fly   682 NQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESE 746
            |..|||||||....|.:|...|:...:.....:|..|::||..|:....:....||||..|:..|
  Rat   649 NVTGYYRVNYDKLGWKKLNQQLEKDPKAIPVINRLQLVSDAFALSKNNYIEIETALDLTKYIAKE 713

  Fly   747 QDYVPWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTPIVEKV-------TFTV--------AA 796
            .:.:.|   ...|..|.||....|: .||..|      |:::|.       .:|:        .|
  Rat   714 DEILVW---FEVLVNLINREVVYDV-KNYYLY------PLLKKYFLKRLNSIWTIYSAIIRENMA 768

  Fly   797 DHLENRLRI----KVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVVYYYGLQQVNTE 857
            ...:|.|.:    |...:||.||.|..||.:..||.:|:|.|||...|.|..||....: .:.:.
  Rat   769 SLQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMAHPETAIPPQIEKVVLCNAI-ALGSN 832

  Fly   858 AAWDQVWKLYLDESDAQEKL-KLMNCLTAVQVPWLLQRYINW-------AWDESNVRRQDYFTLL 914
            ..||.::.||:::::.||.| .|::.:...:.|..|.|::.:       .::|:|        |:
  Rat   833 KDWDFLFNLYINKTEEQEDLFHLVHAMGCSKDPRTLNRFMEYDITVFPSRFNETN--------LI 889

  Fly   915 GYISTNPVGQSLVWDYVRENW---------EKLVDRFGINERTLGRLIPTITARFSTETKLEEMQ 970
            ..::.:.||:.:..|::..||         ..|:.::.::       :.|..|..|:....|:.|
  Rat   890 EVVAESEVGRYVAKDFLINNWVAVYESPSLSPLLQQYFVS-------VWTTIAEHSSVHLREDCQ 947

  Fly   971 QFFAKYPEAGAGTAARQQ 988
                 :..||.|.||..|
  Rat   948 -----HRSAGYGVAAVPQ 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	152/425 (36%)
		M1_APN_2	151..602	CDD:189008	172/488 (35%)
		ERAP1_C	677..992	CDD:288671	88/348 (25%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	169/483 (35%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	77/290 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920