DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and rnpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001002741.1	Gene:	rnpep / 437014	ZFINID:	ZDB-GENE-040718-241	Length:	626	Species:	Danio rerio

Alignment Length:	732	Identity:	162/732 - (22%)
Similarity:	273/732 - (37%)	Gaps:	201/732 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEV 197
            |..|..:..||   |.|...:.|.|:.|..:|:.||                       ..|:|:
Zfish    14 AEDVATSSSFR---QFKIEHFHLDLKVDFLQKSISG-----------------------TETIEL 52

  Fly   198 KRLDESGAPLK-DITPTL-----TFAHPEFEYWVTEF-EQPLEAGNYSLLLNFTGSLVDRITGMY 255
            :.:.:|.:.|: ||.|:|     |.:....::..||| .|...:...:||:.|..:.
Zfish    53 QCIQDSQSELQLDIHPSLSVHEITLSQNARDWTRTEFLTQDFTSYGTTLLVKFPTAF-------- 109

  Fly   256 QSSYLDKLK----------------------NRSRSIISTKFEPTYARQAFPCFDEPALKAQFTI 298
              |..|||:                      .:.:..:.|:.:....|..|||||.||:|:.::.
Zfish   110 --SSDDKLQLAIRYTATDGPGVCWLEPEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSA 172

  Fly   299 TVARPSGDEYHVLSNMPVASEYVDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALK 363
            .|..|.|.. .|:|.........||   ...|....|:..||.|..|.|.|..|     .....:
Zfish   173 AVQVPDGFT-AVMSANKWEQRKADG---AFLFTMEHPIPAYLVALAVGDLQSAE-----VGPRTR 228

  Fly   364 VYAPPAQVEKTQYALDTAAGVMAYYINYFNVS------YALPKLDLVAI-PDFVSGAMENWGLVT 421
            |:..|..::..:...|....      ::.:|.      |...:.|::.: |.|..|.||| ..:|
Zfish   229 VWTEPCLLQAAKQEYDNVIE------DFLSVGEKLFGPYVWGRYDVLFMPPSFPFGGMEN-PCLT 286

  Fly   422 FRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMH 486
            |....||        ...:.:|.|:.||:.|.|||||||...|.|.||||||..:.:.:..::::
Zfish   287 FVTPCLL--------AGDRSLADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCRELY 343

  Fly   487 PE---------------WDMDNQFVIEELHPVLTIDATLASHPIVK---SIESPAEITEYFDTIT 533
            .|               ..|||               |...||:.|   .||...:..:.::...
Zfish   344 GEAYTCLEAATGKALLRQHMDN---------------TGEDHPLNKLRVKIEPGVDPDDTYNETP 393

  Fly   534 YSKGAALVRMLENLVGEEK-----LRNATTRYLVRHIYSTATTEDYL--------TAVEEEEGLE 585
            |.||...|..|.:|.|::.     |:....::..|.:.:....|.||        ..|.:.|||:
Zfish   394 YEKGFCFVSYLAHLTGDQSRFDTFLKAYVEKFKFRSVLAEDALEFYLEYFPELKERNVHKIEGLD 458

  Fly   586 FDVKQIMQTWTEQMGL-PVVEVEKSGSTY----KLTQKRFLANEDDYAAEAEASSFNYRWSIPIT 645
            ||      :|....|. |.|....:|.|.    :|..:::|::..|..:..:....:::     |
Zfish   459 FD------SWLNVPGWPPYVPDLSAGQTLMKPAELLAEKWLSHNLDLESICKTDLKSWK-----T 512

  Fly   646 YTSSINSEVQSLIFNHNDNEATITLP-------EE--ASWIKINTNQVGYYRVNYGSEQWAELIS 701
            |        |::.|.....|.: .||       ||  :..||.|..::        ..:||::::
Zfish   513 Y--------QTVYFLDRILEKS-PLPDGNLKKLEECYSQIIKSNNAEL--------KVRWAQIVA 560

  Fly   702 ALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRV 766
              ||.   :|...: |:   .:.|::.|:..|::.:....:..||:        |.|||......
Zfish   561 --KNQ---YSPGFQ-HI---RDFLSSQGKQKYTLPVYRALWNGSEE--------TKALAIEMFSA 608

  Fly   767 YYTDLYTNYTTYARKLL 783
            ....|:.|...|.:|::
Zfish   609 TSGQLHVNVRNYVKKII 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	102/447 (23%)
		M1_APN_2	151..602	CDD:189008	118/518 (23%)
		ERAP1_C	677..992	CDD:288671	22/107 (21%)
rnpep	NP_001002741.1	leuko_A4_hydro	16..623	CDD:274120	160/726 (22%)
		M1_LTA4H	16..464	CDD:189006	122/528 (23%)
		Leuk-A4-hydro_C	484..624	CDD:286244	33/178 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810