DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and CG14516

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	1065	Identity:	343/1065 - (32%)
Similarity:	533/1065 - (50%)	Gaps:	148/1065 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RPRSSLSTDDNHRIKDTNRPHKARSNTILTLAAFCVFLLVLCGFLLGALVYVGKNIAEEHQRQQH 72
            ||.::.:...........|.:.....|.:.||:|.:..|:..||    :||   |.|...:.:..
  Fly    26 RPMNAATPTTTTTFSKGGRRYSVSLTTAILLASFFICTLLAVGF----IVY---NFATCAELEPD 83

  Fly    73 ANASQWALNSTIRTVYVDRDQLLSTKPIISVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVL 137
            ::......:..:|.:....|             |...|...|
  Fly    84 SDEDVVCTSYHLRRLKAGHD-------------DTPKYDRDV----------------------- 112

  Fly   138 QNLGFRLPKQIKPSKYRLHLRPDLERK-NYSGNISISLQVLEPIAFIPVHVKQLNV--STVEVKR 199
                 |||..|:|.||.:.:.|.|... .::|::.|.::|||....|.:|.::||:  |...|.|
  Fly   113 -----RLPHSIRPLKYNITIEPQLSGNFTFAGSVQIRIRVLEDCYNITMHAEELNISRSDASVHR 172

  Fly   200 LDESGAPLKDITPTLTFAHPEF-----EYWVTE-FEQPLEAGNYSLLLNFTGSLVDRITGMYQSS 258
            :..:|.|..|...    .|.::     :::|.| :::.|:...|.:.|.|.|.:.|.:.|.|:||
  Fly   173 VQNNGEPEGDGLR----IHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQGFYRSS 233

  Fly   259 YLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDG 323
            |  ::.|.:|.:.||:|:.|.||:||||||||||||.||:.:|||.  ....:||||:.|.....
  Fly   234 Y--EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPR--NMTTISNMPIVSSNDHA 294

  Fly   324 DITEVT---FAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVM 385
            .:....   |||::||||||.|:.:|||    |.:...:.|  |:|....::..:|||.....::
  Fly   295 TMPSYVWDHFAESLPMSTYLVAYAISDF----THISSGNFA--VWARADAIKSAEYALSVGPRIL 353

  Fly   386 AYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHEL 450
            .:..::|||::.|||:|::|:|:|.:||||||||:||||||:|||...:::.||||||.||.|||
  Fly   354 TFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVGHEL 418

  Fly   451 AHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI 515
            ||||||||||.:||:|:||||||||::||.....:.|||...:|||:.||..|..:||...||.|
  Fly   419 AHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTSHKI 483

  Fly   516 VKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTED---YLTA 577
            ...:.:|.||:|.||.|:|:||:.::||:.:.:.....|...::||....|::||.:|   :||.
  Fly   484 SHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHFLTV 548

  Fly   578 VEEEEGLEFD---VKQIMQTWTEQMGLPVVEVEK--SGSTYKLTQKRFL----ANEDDYAAEAEA 633
            ..:..||..|   ||:||.|||.|.|.|||:|.:  :....:|.|.||:    ..||:
  Fly   549 EAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDE------- 606

  Fly   634 SSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEE------------ASWIKINTNQVGY 686
               :..|.||||:|:  :||:     |..:...|..:|..            |.|...|..|.||
  Fly   607 ---SLLWYIPITFTT--DSEL-----NFANTRPTTWMPRTKLYELENRELSLAKWFIFNVQQTGY 661

  Fly   687 YRVNYGSEQWAELISALK--NSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDY 749
            |||||..|.|..:...|.  ::.|..:.|:||.|::|...||....|:|..|::|..||..|..:
  Fly   662 YRVNYDLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGH 726

  Fly   750 VPWSVGTSALATLRNRVYYTDLYTN------YTTYARKLLTPIVEKVTFTVAADHLENRL----R 804
            |||.      |.:.|.::...::.|      ...|..|.|..:.::|.|..:.|..|:.|    |
  Fly   727 VPWK------AAISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQVGFKDSQDESEDILVKLKR 785

  Fly   805 IKVLSSACSLGHESSLQQAVTLFNQWLASPETRPN----PDIRDVVYYYGLQQVNTEAAWDQVWK 865
            ..:||.||.|||:..:.:|...|..|:.:|....|    |::|.|||...: |..||..||..::
  Fly   786 ADILSMACHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAI-QYGTEYEWDFAFE 849

  Fly   866 LYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDY 930
            .:|..:...||..|:|.|...:.||||.|::.......::|:||.|.:...:||..|||::.:|:
  Fly   850 RFLKTNVPGEKDLLLNALGCSKEPWLLYRFLRRGISGQHIRKQDLFRVFAAVSTTVVGQNIAFDF 914

  Fly   931 VRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFA----KYPEAGAGTAARQQALE 991
            :|.||:::....|....::..|....|..|:::.:|.|.:.|..    .|..      ..||.:|
  Fly   915 LRNNWQEIKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFVKDAHWDYDR------PVQQIVE 973

  Fly   992 AVKANIKWLAANKAQVGEWLANYVQ 1016
            .::.::.|:..|...:..||.|..|
  Fly   974 HIETSVDWMNKNYKSIVRWLENEAQ 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	171/405 (42%)
		M1_APN_2	151..602	CDD:189008	191/468 (41%)
		ERAP1_C	677..992	CDD:288671	98/334 (29%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	171/405 (42%)
		M1_APN_2	121..576	CDD:189008	191/468 (41%)
		ERAP1_C	652..974	CDD:288671	98/334 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462039
Domainoid	1	1.000	133	1.000	Domainoid score	I3134
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm14800
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	12	11.830