DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and CG31233

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	959	Identity:	287/959 - (29%)
Similarity:	473/959 - (49%)	Gaps:	97/959 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SIMATVAPAVKAASKV--LQNL---------------GFRLPKQIKPSKYRLHLRPDLERKN--Y 166
            :|.||.|..|:....:  ||:|               .:|||....||.|.:.|..::...:  :
  Fly    18 AISATQAAVVRQYPILDHLQHLENPMQRLVVPLADEDNYRLPYDTIPSHYAVSLSTNVHTGDTVF 82

  Fly   167 SGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPLKDIT-------PTLTFA-----HP 219
            :|.::|:|.||.....|.||.:||...|..:.:...:.|..:::.       ..|||:     .|
  Fly    83 NGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAVAQELVYEYEAEREFLTFSKTGLTFP 147

  Fly   220 EFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAF 284
            |...|:             |.:|:.|.|.....|.|.|:|.|: :..::.:.:|:||.|.||.||
  Fly   148 EDTTWI-------------LTINYQGHLRTDNGGFYLSTYTDE-EGNTKYLATTQFESTDARHAF 198

  Fly   285 PCFDEPALKAQFTITVAR-PSGDEYHVLSNMPVASEYVDGDITEVTFAETVPMSTYLAAFVVSDF 348
            ||:|||:.:|:||||:.. ||   |:.:|||||.|....| :|  .|.:||.|.:||.||:||:|
  Fly   199 PCYDEPSKRAEFTITIKHDPS---YNAISNMPVDSSSTSG-VT--VFQKTVNMPSYLVAFIVSEF 257

  Fly   349 QYKETTVEGTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGA 413
            .:.|..:.|  :..:|::......:.::||.|...|......||:|.:||||||...||||.:||
  Fly   258 VFSEGELNG--LPQRVFSRNGTEHEQEWALTTGMLVEKRLSGYFDVPFALPKLDQAGIPDFAAGA 320

  Fly   414 MENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLE 478
            ||||||.|:||..|||:...|::..:..:|.:.|||.||.|||:||.:.||:.|||.||||:..|
  Fly   321 MENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFATLFE 385

  Fly   479 YKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRM 543
            ...|...:||||:...|........|..||:..:.|:...::.|:||...:|:::|:|..:::.|
  Fly   386 NLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMSHFVQKPSEIALLYDSVSYAKAGSVLDM 450

  Fly   544 ----LENLVGEEKLRNATTRYLVRHIYSTATTEDYL-----TAVEEEEGLEFDVKQIMQTWTEQM 599
                |.|.|.:..|.|    |||.:.::.|......     .||||...::..|..:|.:||.|.
  Fly   451 WRHALTNTVFQRGLHN----YLVDNQFTAANPSKLFEAIAKAAVEENYEVKATVPDMMGSWTNQG 511

  Fly   600 GLPVVEVEKSGSTYKLTQKRFL-ANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSLIFNH-- 661
            |:|::.|.::......|.|:.: .|:.||..:.       .|.:||.|..|.|.:.::....|
  Fly   512 GVPLLTVTRNYDNGSFTVKQSVYTNDKDYTNDK-------LWYVPINYAESKNPDFRNTEATHYL 569

  Fly   662 -NDNEATITLP-EEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANT 724
             |.:|.||... ::.:|:.:|....|||||.|.::.:..:.|||..........:||.|:||...
  Fly   570 LNQSEITIYSDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITRPHKIDPRNRAQLINDLYR 634

  Fly   725 LAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDL-YTNYTTYARKLLTPIVE 788
            .|.:|::.::..|:|::||..|..|.||| .|:.:.||.||....|. |.|:..|.|:|::...:
  Fly   635 FATSGRVPHATLLELLTYLPQEDQYSPWS-ATNTVITLLNRYLSGDADYGNFQFYVRELVSLQFD 698

  Fly   789 K--VTFTVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVVYYYGL 851
            |  |.......||....|..:::.||..|.|:.|.:....... |....|:..|:::..||..||
  Fly   699 KFGVNDNKGDHHLVPFTRNVLINLACLAGLENCLTETTAKLTA-LVEEGTKIEPNLQSQVYCNGL 762

  Fly   852 QQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLGY 916
            :|.: :..:|.|:...|:.:|..|:..|::.|...|....|::::..:.:...:|.|:..|:|..
  Fly   763 KQAD-DKTFDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSP 826

  Fly   917 I-STNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPT------ITARFSTETKLEEMQQFFA 974
            : |...||..:..:::::||||    :|......|.:.|.      |:|....:.:.:.:|:...
  Fly   827 VYSRGEVGLLVAIEFLQKNWEK----YGQLNSGFGGVNPLYSDIVGISAYTVNDKQKDALQELVD 887

  Fly   975 KYPEAGAGTAARQQALEA-VKANIKWLAANKAQVGEWLANYVQQSSVTN 1022
            ....:....:..|.:::: |.||..|||:|:..:..|:|.:...||..|
  Fly   888 TVKGSEYVPSTLQDSVDSNVNANYAWLASNRDPLMTWVAGFRSGSSALN 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	145/408 (36%)
		M1_APN_2	151..602	CDD:189008	162/474 (34%)
		ERAP1_C	677..992	CDD:288671	82/324 (25%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	145/407 (36%)
		M1_APN_2	65..514	CDD:189008	162/474 (34%)
		ERAP1_C	587..905	CDD:288671	82/324 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462045
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.940