DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and CG8774

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	423/891 - (47%)
Similarity:	591/891 - (66%)	Gaps:	22/891 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 FRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAP 206
            :|||..:.|:.|.|:..||||..|::|...||::|:|....|.:|...|::::|.|...:.....
  Fly    66 YRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFE 130

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEA-GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            |::          |.::.:....:.|.. .:.:|.:.|.|.:.|::.|:|.|:||:: ...:|:|
  Fly   131 LEE----------ERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNE-AGATRTI 184

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITEVTFAETVP 335
            .:|||||||||||||||||||:||.|.|||..||| .||.:|||........||.||..|..:|.
  Fly   185 STTKFEPTYARQAFPCFDEPAMKATFAITVVHPSG-SYHAVSNMQQTESNYLGDYTEAIFETSVS 248

  Fly   336 MSTYLAAFVVSDFQYKETTVE----GTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSY 396
            |||||...:||||..:.|||:    |...:::.||...|:.|.::||:....|..|||.|:.|.|
  Fly   249 MSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPY 313

  Fly   397 ALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTM 461
            .|.|||:.|||||.|||||:|||||:||||||||.|.||:.|||.:|..:|||:|||||||||||
  Fly   314 PLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTM 378

  Fly   462 NWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEIT 526
            .||||||||||||.:::||||..:||:|.|..||.|..|.|||..||.|:|||||:.:|||.|||
  Fly   379 KWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEIT 443

  Fly   527 EYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQI 591
            ..||||:|.||.:::||||.|||.||...|.|.|||:|.::...|:|:||.||... .:.|:|::
  Fly   444 AIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVV-TDLDIKKL 507

  Fly   592 MQTWTEQMGLPVVEVEK-SGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQ 655
            |.|||||||.||:.|.| :..::|:||:|||:|...|......|::.|:||:|||:.:...|| .
  Fly   508 MLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSE-N 571

  Fly   656 SLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLN 720
            |.|::::.:...|.:|.|..|||:|.||.|||||||....||.||..|..|...|..|||.||||
  Fly   572 SFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLN 636

  Fly   721 DANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTP 785
            ||..||.|.||:|.:.||:.:||..|:|:|||.|.::.|.:|...:.:::.|.:|.||||.|:..
  Fly   637 DAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLIAG 701

  Fly   786 IVEKVTFTVAAD-HLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVVYYY 849
            :.|:|.:||.|| ||:||||:.:|::||:||....||||...|:.:|.:|.|||:||:|::||||
  Fly   702 VYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYY 766

  Fly   850 GLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWA-WDESNVRRQDYFTL 913
            |:||..::::|||:::|::.|:||.||||||..|:.|:....|..::..| .|||.||.|||||.
  Fly   767 GMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTC 831

  Fly   914 LGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPE 978
            :.||:.||||:.:||::.||.|.:|..|||:|.|..||||..|||.|::..||||:|.||:||||
  Fly   832 VQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPE 896

  Fly   979 AGAGTAARQQALEAVKANIKWLAANKAQVGEWLANYVQQSSVTNRI 1024
            :|||..:|.:|:|.:|.||:||:.|:|.:.:||:......:..|::
  Fly   897 SGAGANSRLEAVETIKYNIEWLSRNEADITDWLSGTASPLTKKNQL 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	194/398 (49%)
		M1_APN_2	151..602	CDD:189008	223/455 (49%)
		ERAP1_C	677..992	CDD:288671	158/316 (50%)
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	194/398 (49%)
		M1_APN_2	75..518	CDD:189008	223/455 (49%)
		ERAP1_C	593..910	CDD:288671	158/316 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468260
Domainoid	1	1.000	261	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	633	1.000	Inparanoid score	I811
Isobase	1	0.950	-	0	Normalized mean entropy	S1872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm26111
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
	14	13.780