DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and CG3502

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_611781.3	Gene:	CG3502 / 37695	FlyBaseID:	FBgn0046253	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	941	Identity:	259/941 - (27%)
Similarity:	422/941 - (44%)	Gaps:	120/941 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLER--KNYSGNISISLQVLEPIAFIP 184
            |...:.|:::|..:     .:|||:.::|..|.|.:...|..  :.:.|:::|.|...|....|.
  Fly    13 IFLILVPSIRAVYE-----DYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNIT 72

  Fly   185 VHVKQLNVS---TVEVKRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAGN-YSLLLNFTG 245
            :|...|.:.   |..|...::.|....::.....|       ::....:.|.... |.|.::|..
  Fly    73 LHAAYLKIDENRTSVVSGQEKFGVNRIEVNEVHNF-------YILHLGRELVKDQIYKLEMHFKA 130

  Fly   246 SLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHV 310
            .|.|..:|.|:|:|.|.:......:..|:|.||:|||||||||||:.||.|.||:.      ||.
  Fly   131 GLNDSQSGYYKSNYTDIVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLG------YHK 189

  Fly   311 ----LSNMPV--------ASEYV--DGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTS-- 359
                ||.|||        .:.||  |.|    |...|   ||||.||.|.|.:...|....||
  Fly   190 KYMGLSGMPVLRCQDHDSLTNYVWCDHD----TLLRT---STYLVAFAVHDLENAATEESKTSNR 247

  Fly   360 IALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRE 424
            :..:.:..|..:.:...:::.|..::::|.|.|.:::.|.|:|.:.:|.....|||||||||:.|
  Fly   248 VIFRNWMQPKLLGQEMISMEIAPKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNE 312

  Fly   425 TALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEW 489
            ..|..::.......|...|..||||.|||||||||||||||||||.||.:::..|..:..:.|||
  Fly   313 ERLPQNQGDYPQKQKDSTAFTVAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEW 377

  Fly   490 DMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLR 554
            ....:|:..:|....:.|:......|.|.:::|||:...|....|.||:..:|||..|||||...
  Fly   378 RRGERFISRDLANFFSKDSNATVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFF 442

  Fly   555 NATTRYLVRHIYSTATTEDYLTAVE------EEEGLEFDVKQIMQTWTEQMGLPVVEVEKSGSTY 613
            :....:|.|..:......|...:::      :....:|::.:.|.:||.|.|.|:|.:.::..|.
  Fly   443 HGIRSFLERFSFGNVAQADLWNSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTG 507

  Fly   614 KLT--QKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSL-IFNHND---------NEA 666
            ::|  |.||.   .::..|..:|.    |.:|:.:..      |:| .||...         |..
  Fly   508 EVTLNQSRFF---QEHGIEKASSC----WWVPLRFVR------QNLPDFNQTTPQFWLECPLNTK 559

  Fly   667 TITLPEEAS---WIKINTNQVGYYRVNYGSEQWAELISALKNSRET--FSTADRAHLLNDANTLA 726
            .:.||:..|   |:.:|......:||||....|..:|.:|:|...:  ....::|.||:|...||
  Fly   560 VLKLPDHLSTDEWVILNPQVATIFRVNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALA 624

  Fly   727 AAGQLNYSVALDLISYLESEQDYVPW--SVG-TSALATLRNRVYYTDLYTNYTTYARKLLTPIVE 788
            |.....|..|.||:.||:.|||::||  ::| .:.|..|.| |...:.:.|   |.:|||.|:..
  Fly   625 AVRLHKYDKAFDLLEYLKKEQDFLPWQRAIGILNRLGALLN-VAEANKFKN---YMQKLLLPLYN 685

  Fly   789 KVTFTVAADHLENRLRIK-------VLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVV 846
            :  |...:...|.:..||       ..|.||.........||..|........:.....|.:.|.
  Fly   686 R--FPKLSGIREAKPAIKDIPFAHFAYSQACRYHVADCTDQAKILAITHRTEGQLELPSDFQKVA 748

  Fly   847 YYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYF 911
             |..|.....:|.:.:|:.|:.:.::..::..|.:.|..|:.....::::|:..:.......|.:
  Fly   749 -YCSLLDEGGDAEFLEVFGLFQNSTNGSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCY 812

  Fly   912 TLL--GYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTE------TKLEE 968
            .|.  ..::..|: .|...:|:..:.:||.::|...|.| |.|:.......|||      .:||:
  Fly   813 MLAVKSALNREPL-VSPTANYIISHAKKLGEKFKKKELT-GLLLSLAQNLRSTEEIDRLKAQLED 875

  Fly   969 MQQFFAKYPEAGAGTAARQQALEAVKANIKW 999
            :::|          ....::||...|.|.||
  Fly   876 LKEF----------EEPLKKALYQGKMNQKW 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	134/415 (32%)
		M1_APN_2	151..602	CDD:189008	149/478 (31%)
		ERAP1_C	677..992	CDD:288671	79/334 (24%)
CG3502	NP_611781.3	Peptidase_M1	29..425	CDD:279741	134/415 (32%)
		M1_APN_2	37..496	CDD:189008	149/478 (31%)
		ERAP1_C	573..890	CDD:288671	79/335 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462021
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	8	7.850