DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Trhde

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	302/900 - (33%)
Similarity:	482/900 - (53%)	Gaps:	52/900 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGA-P 206
            ||...:||..|.|.|...:|...:||.:::.:.......::.:|..::.|..|:|......|| |
  Rat   182 RLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQVAEDRAFGAVP 246

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEA-GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            :...     |.:|:.:..|....:.|:| .:|:|.:.:...:.:.:.|.::|||:  :....|.:
  Rat   247 VAGF-----FLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYV--IHGERRFL 304

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYV--DGDITEVTFAET 333
            ..|:|.||:||:||||||||..||.|.|::...:  .|..||||||.:...  ||.:|: .|::|
  Rat   305 GVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSVFEEDGWVTD-HFSQT 366

  Fly   334 VPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEK--TQYALDTAAGVMAYYINYFNVSY 396
            ..||||..|:.:.:|.|:|||.: :.:.:::||.|..:.:  ..|||.....::.:|.:||.|.|
  Rat   367 PLMSTYYLAWAICNFTYRETTTK-SGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPY 430

  Fly   397 ALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTM 461
            :||||||:|:|.....|||||||..|.|..:|.|.|.||......|.:|:.||:.|||||:|||.
  Rat   431 SLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTP 495

  Fly   462 NWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQ-FVIEELHPVLTIDATLASHPIVKSIESPAEI 525
            .||.|:||.||||.:.|:.|...::|.|:|:.| |:.:.||.|:.:|...:|||:.:.:....:|
  Rat   496 VWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDI 560

  Fly   526 TEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEE---EEGLEFD 587
            .:.||.|.|.|||||:|||.|.:|....:.....||..|.|..|...|....:.|   ..|...:
  Rat   561 DKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVN 625

  Fly   588 VKQIMQTWTEQMGLPVVEV---EKSGSTYKLTQKRFLANEDDYAAEAEA---SSFNYRWSIPITY 646
            ::::|..||.|||.||:.:   ..:.:...:||:.|:.   |..|:.:|   .:.:|.|.||:|.
  Rat   626 IQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIY---DIGAKTKALQLQNSSYLWQIPLTI 687

  Fly   647 TSSINSEVQS--LIFNHNDNE-ATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRE 708
            .....|.|.|  :|:..|.:| ..||..::.|||..|.||.||:||||....|..||..|..:.|
  Rat   688 VVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRNHE 752

  Fly   709 TFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSA---LATLRNRVYYTD 770
            ..|.::||.|::||.:||.||.|..::.|::|.||..|:|::||...:.|   |..|.:|:...:
  Rat   753 VLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYN 817

  Fly   771 LYTNY------TTYARKLLTPIVEKVTF---TVAADHLENRLRIKVLSSACSLGHESSLQQAVTL 826
            ::..|      |||: ||..|   |..|   .|.|.:....||.:|:..|||.|::...|||.||
  Rat   818 IFNEYILKQVATTYS-KLGWP---KNNFNGSVVQASYQHEELRREVIMLACSFGNKHCHQQASTL 878

  Fly   827 FNQWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWL 891
            .:.|::|...|...::||:||..|:..:: |..|:.:|..:...:...||..|:..||......|
  Rat   879 ISDWISSNRNRIPLNVRDIVYCTGVSLLD-EDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNL 942

  Fly   892 LQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTI 956
            |.|.:|.:.:...|..||...::.:::.||.|:.|.|.:.|:.|:.|..|:|.......:||..:
  Rat   943 LSRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGV 1007

  Fly   957 TARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            |...:||.:|:|::.|...|.  |..:|:..:|:|.|:||::|....:.::.:||
  Rat  1008 TEFLNTEGELKELKNFMKSYD--GVASASFSRAVETVEANVRWKRLYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	142/400 (36%)
		M1_APN_2	151..602	CDD:189008	162/460 (35%)
		ERAP1_C	677..992	CDD:288671	106/326 (33%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	158/455 (35%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	109/330 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920