DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and lnpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	989	Identity:	316/989 - (31%)
Similarity:	518/989 - (52%)	Gaps:	98/989 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KNIAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTKP-----IISVLSDNRFYT--------- 111
            ::.|..:.|||.:|:.                ..||||.     :|.||..:.|..
Zfish    98 RSAASSYTRQQPSNSC----------------SPLSTKTTAVGVLILVLVVSMFMVIYFVPSCTF 146

  Fly   112 TQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQV 176
            |:....|.:|.|:::.| :..:.::......|||..:.|..|.:.|.|||....:.||:||.:.|
Zfish   147 TKKGCQKSNSSMSSIYP-ISTSGELFPWTDLRLPVSVHPVHYNISLHPDLNSMTFQGNVSIVVLV 210

  Fly   177 LEPIAFIPVHVKQLNVSTVEVKRLDESGAPLKDITPTLTFAHPEFEY-----W---VTEFEQPLE 233
            :.....|.:|...:|:..|                   ||...|:.:     |   ..:|.:.|:
Zfish   211 MHETKNIILHSSDMNIIKV-------------------TFDDKEYRFLEYKPWQQIAIKFPEDLK 256

  Fly   234 AGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTI 298
            .|.|.|..::..:|.:...|.|.|||:|....: |.:.:|:|||..||:|||||||||.|:.|.:
Zfish   257 KGQYVLKFSYKANLSNSYDGFYNSSYVDTAGTK-RVLAATQFEPLAARKAFPCFDEPAFKSTFVV 320

  Fly   299 TVARPSGDEYHVLSNMP--VASEYVDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIA 361
            .:.|.:  :|..|||||  ..::..:..:.|..|..:|.|||||.||:|::|......|..|:::
Zfish   321 KMTREA--KYISLSNMPKIKTTDLNENGLQEDEFESSVKMSTYLVAFIVAEFSSHSKNVSKTTVS 383

  Fly   362 LKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETA 426
              |||.|.:.::..|||:||..::.:|..:|.:.|.|.||||||||||::||||||||:|||||.
Zfish   384 --VYAVPDKKDQVHYALETACKLLKFYNTFFEIEYPLSKLDLVAIPDFLAGAMENWGLITFRETT 446

  Fly   427 LLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDM 491
            ||.. :.||..:||.|..|:|||||||||||||||.||||||||||||::::|..::.:.|:.|:
Zfish   447 LLVG-NQSSRFDKQLVTSVIAHELAHQWFGNLVTMRWWNDLWLNEGFATYMQYMSIENVFPDLDI 510

  Fly   492 DNQFVIEELHPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNA 556
            |.:| :......|..||..:|||:...:.:|.::.|.||:::|.|||:::.||...:.:.:....
Zfish   511 DIEF-LNVRFKALAKDALNSSHPVSTFVSTPEQVEEMFDSVSYEKGASILLMLNATLRDGEFHKG 574

  Fly   557 TTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFL 621
            ...||..:..|...::|...::.:......:|.::|.|||...|.|:|.|:::|....|:|:.||
Zfish   575 VIEYLQNYNLSNTESKDLWNSLSQVSKQSLNVSEMMNTWTVHKGFPLVTVKRNGPQVTLSQEHFL 639

  Fly   622 ANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSL--IFNHNDNEATITLPEEASWIKINTNQV 684
            .|.::...::..      |.||:||.:...|.::|.  :|:..|.|||:.||.:..|:|.|....
Zfish   640 LNAENGTDDSSL------WHIPLTYVNDSCSVLRSCKQVFHLKDKEATLQLPGQVKWLKFNFRSD 698

  Fly   685 GYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDY 749
            |:|.|:|..:.|::||||||.......:.|:|.|:|:...|:..|::::...|:|:.|:.:|.:.
Zfish   699 GFYIVHYDEQGWSDLISALKVDVNVLPSEDKAALINNIFALSRLGKVSFRQVLNLMDYIRNETET 763

  Fly   750 VPWSVGTSALATLRNRVYY-------TDLYTNYTTYARKLLTPIVEKVTFTVAADHLENRLRIKV 807
            .|.   |.||:.| .::|.       .:|.::.|||.......::|..::.|.....:..||..:
Zfish   764 APL---TEALSQL-GQIYRLLDKRSDLNLASSMTTYIESHFGSLMESQSWEVETSVSKMTLRSAL 824

  Fly   808 LSSACSLGHESSLQQAVTLFNQWLASPETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDES 871
            |.:||:|...:...||..||:|||||.:|...| |:...|:...   ..|:..|.::...|....
Zfish   825 LETACALNRPNCTTQARRLFDQWLASNKTLQIPSDLMRTVFKVA---AKTDEGWSKLLGSYKHSI 886

  Fly   872 DAQEKLKLMNCLTAVQ----VPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVR 932
            ...||.|::..|.:.|    :.|:||:.:    |.|.::.|::..::..:..:..|....||:::
Zfish   887 YDTEKRKMLEALASTQDVRKIIWVLQKSL----DGSEIQNQEFPLVIHTVCRDFAGYLYAWDFMK 947

  Fly   933 ENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANI 997
            |||||:..:|.|....:..:|.:.|::|||:|.|.|:|.||:.....|:.....|:|:|.:|.|:
Zfish   948 ENWEKITQKFPIGSFAIQSIITSTTSQFSTKTHLAEVQNFFSSLGAKGSQMRIVQEAIETIKHNM 1012

  Fly   998 KWLAANKAQVGEWL 1011
            :|:..|...:..||
Zfish  1013 RWMEKNLNTLQSWL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	160/403 (40%)
		M1_APN_2	151..602	CDD:189008	171/460 (37%)
		ERAP1_C	677..992	CDD:288671	92/326 (28%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	171/460 (37%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	94/329 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920