Protein Alignment CG32473 and Lta4h

DIOPT Version :9

• Sequence 1: NP_731787.1
• Gene: CG32473 / 41636
• FlyBaseID: FBgn0052473
• Length: 1025
• Species: Drosophila melanogaster
• Sequence 2: NP_001025202.1
• Gene: Lta4h / 299732
• RGDID: 1311333
• Length: 611
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 151/614 - (24%)
• Similarity: 232/614 - (37%)
• Gaps: 134/614 - (21%)

  Fly   155 LHLR--PDLERKNYSGNISISLQVLEP-IAFIPVHVKQLNVSTV-----EVK-RLDES----GAP 206
            ||||  .|..|:..:|..::::|..|. :..:.:..|.|.:..|     ||| .|.||    |:|
  Rat    22 LHLRCSVDFARRALTGTAALTVQSQEDNLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSP 86

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSII 271
            ::...|.....:.|     ...|...|....|..|.:   |....|...|..||
  Rat    87 MEISLPIALSKNQE-----VVIEISFETSPKSSALQW---LTPEQTSGKQHPYL----------- 132

  Fly   272 STKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITE--------V 328
            .::.:..:.|...||.|.|::|..:|..|:.|.       ..:.:.|...||:..:        .
  Rat   133 FSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPK-------ELVALMSAIRDGEAPDPEDPSRKIY 190

  Fly   329 TFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALK--VYAPPAQVEKTQYALDTAAGVMAYYINY 391
            .|.:.||:..||.|.||.       .:|...|..:  |::...||||:.|....... |......
  Rat   191 RFNQRVPIPCYLIALVVG-------ALESRQIGPRTLVWSEKEQVEKSAYEFSETES-MLKIAED 247

  Fly   392 FNVSYALPKLDLVAI-PDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWF 455
            ....|...:.||:.: |.|..|.|||..|.....|.|..|:|.|:         |:|||::|.|.
  Rat   248 LGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSN---------VIAHEISHSWT 303

  Fly   456 GNLVTMNWWNDLWLNEGFASFLEYK------GVKQMH----PEW-DMDNQFVIEELHPVLTIDAT 509
            |||||...|:..|||||...:||..      |.|..|    ..| ::.|           ||...
  Rat   304 GNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQN-----------TIKTF 357

  Fly   510 LASHPIVKSIESPAEITE--YFDTITYSKGAALVRMLENLV-GEEKLRNATTRYLVRHIYSTATT 571
            ..|||..|.:....::..  .:.:|.|.||.||:..||.|: |.|........|:.:..|.:.||
  Rat   358 GESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTT 422

  Fly   572 EDYLTAVEEEEGLEFD-VKQI-MQTWTEQMGLPVV----EVEKSGSTYKLTQKRFLANEDDYAAE 630
            :|:.:.:......:.| :.|: ...|....|||.|    :|..:.:...|:|:...|.|:|
  Rat   423 DDWKSFLYAHFKDKVDLLNQVDWNAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEED---- 483

  Fly   631 AEASSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEA----SWIK-----INTNQVGY 686
                            .:|.:.|....:.:|..||....:.::|    ..||     .|.|.:..
  Rat   484 ----------------LNSFSIEDLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINN 532

  Fly   687 YRVNYG------SEQWAELIS-ALKNSRE 708
            ..:.:.      ..:|.|.|. |||.:.|
  Rat   533 SEIRFRWLRLCIQSKWEEAIPLALKMATE 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	107/418 (26%)
		M1_APN_2	151..602	CDD:189008	125/486 (26%)
		ERAP1_C	677..992	CDD:288671	11/44 (25%)
Lta4h	NP_001025202.1	leuko_A4_hydro	6..608	CDD:274120	151/614 (25%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810