DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and TRHDE

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	902	Identity:	304/902 - (33%)
Similarity:	481/902 - (53%)	Gaps:	56/902 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGA-P 206
            ||...:||..|.|.|...:|...:||.:::.:.......::.:|..::.|..|::......|| |
Human   185 RLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVP 249

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEA-GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            :...     |.:|:.:..|....:.|:| .||:|.:.:...:.:.:.|.::|||:  |....|.:
Human   250 VAGF-----FLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYV--LHGERRFL 307

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYV--DGDITEVTFAET 333
            ..|:|.||:||:||||||||..||.|.|::...:  .|..||||||.:...  ||.:|: .|::|
Human   308 GVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSVFEEDGWVTD-HFSQT 369

  Fly   334 VPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEK--TQYALDTAAGVMAYYINYFNVSY 396
            ..||||..|:.:.:|.|:|||.: :.:.:::||.|..:.:  ..|||.....::.:|.:||.|.|
Human   370 PLMSTYYLAWAICNFTYRETTTK-SGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPY 433

  Fly   397 ALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTM 461
            :||||||:|:|.....|||||||..|.|..:|.|.|.||......|.:|:.||:.|||||:|||.
Human   434 SLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTP 498

  Fly   462 NWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQ-FVIEELHPVLTIDATLASHPIVKSIESPAEI 525
            .||.|:||.||||.:.|:.|...::|.|:|:.| |:.:.||.|:.:|...:|||:.:.:....:|
Human   499 VWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDI 563

  Fly   526 TEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEE---EEGLEFD 587
            ...||.|.|.|||||:|||.|.:|....:.....||..|.|..|...|....:.|   ..|...:
Human   564 DRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVN 628

  Fly   588 VKQIMQTWTEQMGLPVVEVEKSGSTYK-----LTQKRFLANEDDYAAEAEA---SSFNYRWSIPI 644
            ::::|..||.|||.||:.:  .|:|..     :||:.|:.   |.:|:.:|   .:.:|.|.||:
Human   629 IQEVMDQWTLQMGYPVITI--LGNTTAENRIIITQQHFIY---DISAKTKALKLQNNSYLWQIPL 688

  Fly   645 TYTSSINSEVQS--LIFNHNDNE-ATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNS 706
            |......|.|.|  :|:..|.:| ..||..::.||:..|.||.||:||||....|..||..|..:
Human   689 TIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRN 753

  Fly   707 RETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSA---LATLRNRVYY 768
            .|..|.::||.|::||.:||.||.|..::.|::|.||..|:|::||...:.|   |..|.:|:..
Human   754 HEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMEN 818

  Fly   769 TDLYTNY------TTYARKLLTPIVEKVTFT---VAADHLENRLRIKVLSSACSLGHESSLQQAV 824
            .:::..|      |||. ||..|   |..|.   |.|.:....||.:|:..|||.|::...|||.
Human   819 YNIFNEYILKQVATTYI-KLGWP---KNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQAS 879

  Fly   825 TLFNQWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVP 889
            ||.:.|::|...|...::||:||..|:..:: |..|:.:|..:...:...||..|:..||.....
Human   880 TLISDWISSNRNRIPLNVRDIVYCTGVSLLD-EDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR 943

  Fly   890 WLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIP 954
            .||.|.:|.:.:...|..||...::.:::.||.|:.|.|.:.|:.|:.|..|:|.......:||.
Human   944 NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLIS 1008

  Fly   955 TITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            .:|...:||.:|:|::.|...|.  |...|:..:|:|.|:||::|....:.::.:||
Human  1009 GVTEFLNTEGELKELKNFMKNYD--GVAAASFSRAVETVEANVRWKMLYQDELFQWL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	143/400 (36%)
		M1_APN_2	151..602	CDD:189008	163/460 (35%)
		ERAP1_C	677..992	CDD:288671	105/326 (32%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	159/455 (35%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	108/330 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920