DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and ANPEP

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	1016	Identity:	337/1016 - (33%)
Similarity:	526/1016 - (51%)	Gaps:	116/1016 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LVLCGFLLG---ALVYVGKNIAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTKPIISVLSDN 107
            |.:.|.|||   ....:..::....::.::||:|..|                ||.|..|
Human    11 LGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVA----------------STTPSAS----- 54

  Fly   108 RFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKN-----YS 167
               .|..|.|      ||.....||.::      :|||..:||..||:.|||.|...:     :.
Human    55 ---ATTNPAS------ATTLDQSKAWNR------YRLPNTLKPDSYRVTLRPYLTPNDRGLYVFK 104

  Fly   168 GNISISLQVLEPIAFIPVHVKQLNVSTVEVKRL---DESGAPLKDITPTLTFAHPEFEYWVTEFE 229
            |:.::.....|....|.:|.|:||.:..:..|:   ...|:...||..| ....|. ||.|...:
Human   105 GSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKT-ELVEPT-EYLVVHLK 167

  Fly   230 QPL-EAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALK 293
            ..| :...|.:...|.|.|.|.:.|.|:|.|::  .|..:.:.:|:.:...||::||||||||:|
Human   168 GSLVKDSQYEMDSEFEGELADDLAGFYRSEYME--GNVRKVVATTQMQAADARKSFPCFDEPAMK 230

  Fly   294 AQFTITVARPSGDEYHVLSNM-------PVASEYVDGDITEVTFAETVPMSTYLAAFVVSDFQYK 351
            |:|.||:..|.  :...||||       |: .|..:.::||  |..|..|||||.||:||:|.|.
Human   231 AEFNITLIHPK--DLTALSNMLPKGPSTPL-PEDPNWNVTE--FHTTPKMSTYLLAFIVSEFDYV 290

  Fly   352 ETTVEGTSIALKVYAPPAQVE--KTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAM 414
            |... ...:.::::|.|:.:.  ...|||:....::.::..:::..|.|||.|.:.:|||.:|||
Human   291 EKQA-SNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAM 354

  Fly   415 ENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEY 479
            |||||||:||.:||:|..:|||.||:||..|:||||||||||||||:.|||||||||||||::||
Human   355 ENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEY 419

  Fly   480 KGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI---VKSIESPAEITEYFDTITYSKGAALV 541
            .|.....|.|::.:..|:.:::.|:.:||..:|||:   ...|.:||:|:|.||.|:|||||:::
Human   420 LGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVL 484

  Fly   542 RMLENLVGEEKLRNATTRYLVRHIYSTATT-----EDYLTAVEEEEGLEF--DVKQIMQTWTEQM 599
            |||.:.:.|:..:.....||  |.::...|     .|:|........::.  .|:.||..||.||
Human   485 RMLSSFLSEDVFKQGLASYL--HTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQM 547

  Fly   600 GLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSS---------INSEVQ 655
            |.||:.|:.|..|  |:|:.||.:.|...  ...|.|||.|.:|||....         |:...|
Human   548 GFPVITVDTSTGT--LSQEHFLLDPDSNV--TRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQ 608

  Fly   656 SLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLN 720
            :.:|:.:.||          |:.:|.|..|||||||..|.|.::.:.|:.........:||.::|
Human   609 NDLFSTSGNE----------WVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIIN 663

  Fly   721 DANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTP 785
            ||..||:|.::..::||:...:|..|:.|:||....|:|:..:.....:::|.....|.:|.:||
Human   664 DAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTP 728

  Fly   786 IVEKVTF--------TVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRP-NPD 841
            :.  :.|        .:..:.::....:..:|:|||.|.....:....||.||:.:|...| :|:
Human   729 LF--IHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPN 791

  Fly   842 IRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVR 906
            :|..||...:.| ..|..||..|:.:.:.:...|..||...|...:..|:|.||:::..:...:|
Human   792 LRSTVYCNAIAQ-GGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIR 855

  Fly   907 RQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQ 971
            :||..:.:..|:.|.:||.||||:|:.||:||.:.:|....:...||..:|.|||||.:|::::|
Human   856 KQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQ 920

  Fly   972 FFAKYPEA--GAGTAARQQALEAVKANIKWLAANKAQVGEW 1010
            |.....|.  |:||.|.:||||..||||||:..||..|.:|
Human   921 FKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQW 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	162/414 (39%)
		M1_APN_2	151..602	CDD:189008	178/478 (37%)
		ERAP1_C	677..992	CDD:288671	99/325 (30%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		13/64 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		11/51 (22%)
		Metalloprotease	69..967		319/928 (34%)
		M1_APN-Q_like	84..545	CDD:341064	174/472 (37%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		2/7 (29%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	101/329 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850