DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and ape2

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_595998.1	Gene:	ape2 / 2540648	PomBaseID:	SPBC1921.05	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	890	Identity:	281/890 - (31%)
Similarity:	463/890 - (52%)	Gaps:	55/890 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPLK 208
            |||.:||..|.|.|.||||...|.|.:.::|.|||....|.:|...|.:.|          |.|:
pombe    20 LPKNVKPIHYDLSLYPDLETFTYGGKVVVTLDVLEDSNSITLHGINLRILT----------AALE 74

  Fly   209 DITPTLTFAHPEF--EYWVTEFEQPLEAGNYSLL-LNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            ..:.|:..:...:  |..|.:|...:.|.:.::| |.||..:...:.|.|:|||:|...| ::.:
pombe    75 WGSQTVWASEVSYGDERIVLQFPSTVPANSVAVLTLPFTARISSGMEGFYRSSYVDSDGN-TKYL 138

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITEVTFAETVP 335
            .:|:.|||.||:||||:|||||||.|||.:.  :.:.|.:||||....|.|...:....||||..
pombe   139 ATTQMEPTSARRAFPCWDEPALKATFTIDIT--AKENYTILSNMNAVEETVKDGLKTARFAETCR 201

  Fly   336 MSTYLAAFVVSDFQYKETTVEG---TSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYA 397
            |||||.|::|::.:|.|....|   ..:.::||..|...|:.::|.:..|..:.::...|...|.
pombe   202 MSTYLLAWIVAELEYVEYFTPGKHCPRLPVRVYTTPGFSEQGKFAAELGAKTLDFFSGVFGEPYP 266

  Fly   398 LPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMN 462
            |||.|:||||||.:||||||||||:|..|:|..|.::::| .:|||.||.||||||||||||||.
pombe   267 LPKCDMVAIPDFEAGAMENWGLVTYRLAAILVSEDSAATV-IERVAEVVQHELAHQWFGNLVTMQ 330

  Fly   463 WWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITE 527
            :|:.||||||||:::.:......:|||.:...:|.:.|...|::||..:||||...|....||.:
pombe   331 FWDGLWLNEGFATWMSWFSCNHFYPEWKVWESYVTDNLQSALSLDALRSSHPIEVPIMHDYEINQ 395

  Fly   528 YFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQIM 592
            .||.|:||||:.::||:...|||:.......:|:.:|.|....|||...|:..|.|.  |:...|
pombe   396 IFDAISYSKGSCVIRMVSKYVGEDTFIKGIQKYISKHRYGNTVTEDLWAALSAESGQ--DISSTM 458

  Fly   593 QTWTEQMGLPVVEV-EKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTS-----SIN 651
            ..||::.|.||:.| |.:.....:.|.|||:..|   .:.|..:..| |: |:...:     ::.
pombe   459 HNWTKKTGYPVLSVSETNDGELLIEQHRFLSTGD---VKPEEDTVIY-WA-PLKLKTMKDGKAVV 518

  Fly   652 SEVQSLIFNHNDNEATITLPEEA-SWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADR 715
            .|...|    :|....|.:.:|| ...|:|:.|.|.|||||.::...:|........:..|..||
pombe   519 DEKAVL----SDRSKKIKVDKEALESYKLNSEQSGIYRVNYSADHLKKLSQIAVEKPDYLSVEDR 579

  Fly   716 AHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYTTYAR 780
            |.|:.|..:|:.||....|..||||...:.|.::|.::...:.|..:::.:.:..  ::.....:
pombe   580 AGLIADVASLSRAGYGKVSSTLDLIKTWKDEPNFVVFAEMLARLNGIKSTLRFES--SDIIAAMK 642

  Fly   781 KLLTPIVEKVT------FTVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPN 839
            ||:..:.....      |....||:..:.:..|.:.|...|.:..::.|::.|:.:.:..::..|
pombe   643 KLVLEVSATKAHSLGWEFKANDDHIIRQFKSTVYNYAGLFGDDKVVKDALSKFDAYASGNKSAIN 707

  Fly   840 PDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWD--- 901
            .::|..|:...::....: :|||:.::|...:|...:   .:||.|..|. ..::||....|
pombe   708 DNLRSAVFNIAIRYGGAK-SWDQLLEIYTKTNDPYVR---NSCLRAFGVT-EDEKYIQKTLDLTL 767

  Fly   902 ESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKL 966
            :..|:.||.:.:|..:||:..|...:|.:...||:||:.|..:.....|.::..:|:.|:..:.:
pombe   768 DPIVKEQDIYLILVTLSTHKNGVLAMWKFATSNWDKLLSRLPVAGTMRGYVVRFVTSGFTHASAI 832

  Fly   967 EEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            :::::|||. .:......|.||:|:.:.||..::..:...:..||
pombe   833 DKIKEFFAD-KDTKLYERALQQSLDTISANSSFIDKSLDDITRWL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	162/398 (41%)
		M1_APN_2	151..602	CDD:189008	178/456 (39%)
		ERAP1_C	677..992	CDD:288671	75/323 (23%)
ape2	NP_595998.1	PepN	24..871	CDD:223385	276/879 (31%)
		M1_APN_2	27..468	CDD:189008	178/456 (39%)
		ERAP1_C	541..857	CDD:288671	75/323 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.910