DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Trhde

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	898	Identity:	297/898 - (33%)
Similarity:	474/898 - (52%)	Gaps:	48/898 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGA-P 206
            ||...:||..|.|.|...:|...:||.:::.:.......::.:|..::.|..|:|......|| |
Mouse   182 RLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQVAEDRAFGAVP 246

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEA-GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSI 270
            :...     |.:|:.:..|....:.|:| .:|:|.:.:...:.:.:.|.::|||:  :....|.:
Mouse   247 VAGF-----FLYPQTQVLVVVLNRTLDAQRHYNLKIIYNALIENELLGFFRSSYV--IHGERRFL 304

  Fly   271 ISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYV--DGDITEVTFAET 333
            ..|:|.||:||:||||||||..||.|.|::...:  .|..||||||.:...  ||.:|: .|::|
Mouse   305 GVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA--TYLSLSNMPVETSVFEEDGWVTD-HFSQT 366

  Fly   334 VPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEK--TQYALDTAAGVMAYYINYFNVSY 396
            ..||||..|:.:.:|.|:|||.: :.:.:::||.|..:.:  ..|||.....::.:|.:||.|.|
Mouse   367 PLMSTYYLAWAICNFTYRETTTK-SGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPY 430

  Fly   397 ALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTM 461
            :||||||:|:|.....|||||||..|.|..:|.|.|.||......|.:|:.||:.|||||:|||.
Mouse   431 SLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTP 495

  Fly   462 NWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQ-FVIEELHPVLTIDATLASHPIVKSIESPAEI 525
            .||.|:||.||||.:.|:.|...::|.|:|:.| |:.:.||.|:.:|...:|||:.:.:....:|
Mouse   496 VWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLRATDI 560

  Fly   526 TEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLTAVEE---EEGLEFD 587
            ...||.|.|.|||||:|||.|.:|....:.....||..|.|..|...|....:.|   ..|...:
Mouse   561 DRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALRRNGKYVN 625

  Fly   588 VKQIMQTWTEQMGLPVVEVEKSGST-----YKLTQKRFLANEDDYAAEAEA---SSFNYRWSIPI 644
            ::::|..||.|||.||:.:  .|:|     ..:||:.|:.   |..|:.:|   .:.:|.|.||:
Mouse   626 IQEVMDQWTLQMGYPVITI--LGNTTAENRILITQQHFIY---DIGAKTKALQLQNSSYLWQIPL 685

  Fly   645 TYTSSINSEVQS--LIFNHNDNE-ATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNS 706
            |......|.|.|  :|:..|.:| ..|...:..|||..|.||.||:||||....|..||..|..:
Mouse   686 TIVVGNRSHVSSEAIIWVSNKSEHHRIAYLDRGSWILGNINQTGYFRVNYDLRNWRLLIDQLIRN 750

  Fly   707 RETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDL 771
            .|..|.::||.|::||.:||.||.|..::.|::|.||..|:|::||...:.||..|...:...:.
Mouse   751 HEVLSVSNRAALIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMEN 815

  Fly   772 YTNYTTYARKLLTPIVEKVTF--------TVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFN 828
            |..:..|..|.:.....|:.:        .|.|.:....||.:|:..|||.|::...|||.||.:
Mouse   816 YNIFNEYILKQVATTYIKLGWPRNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLIS 880

  Fly   829 QWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQ 893
            .|::|...|...::||:||..|:..:: |..|:.:|..:...:...||..|:..||......||.
Mouse   881 DWISSNRNRIPLNVRDIVYCTGVSLLD-EDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLS 944

  Fly   894 RYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITA 958
            |.:|.:.:...|..||...::.:::.||.|:.|.|.:.|:.|:.|..|:|.......:||..:|.
Mouse   945 RLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTE 1009

  Fly   959 RFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            ..:||.:|:|::.|...|.  |..:|:..:|:|.|:||::|....:.::.:||
Mouse  1010 FLNTEGELKELKNFMKSYD--GVASASFSRAVETVEANVRWKRFYQDELFQWL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	142/400 (36%)
		M1_APN_2	151..602	CDD:189008	162/460 (35%)
		ERAP1_C	677..992	CDD:288671	100/322 (31%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	158/455 (35%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	103/326 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020