DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Rnpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_663392.2	Gene:	Rnpep / 215615	MGIID:	2384902	Length:	650	Species:	Mus musculus

Alignment Length:	722	Identity:	158/722 - (21%)
Similarity:	257/722 - (35%)	Gaps:	190/722 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SKYR----LHLRPDLE-----------RKNYSGNISISLQVLEPIAFIPVHVKQ---LNVSTVEV 197
            |.:|    |||..||.           .:..||..::.|:.|.|.....:.:..   |.|:...:
Mouse    29 SSFRAFEILHLHLDLRAEFGPPGPGPGSRGLSGTATLELRCLLPEGASELRLDSHSCLEVTAATL 93

  Fly   198 KRLDESGAPLKDITPT--LTFAHPEFEYW----VTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQ 256
            :|    |.|.....|.  :.|....|.::    ...|.||..|.:     .|...|..|:.....
Mouse    94 RR----GQPGDQQAPAEPVPFHTQPFSHYGQALCVAFRQPCGAAD-----RFELELTYRVGEGPG 149

  Fly   257 SSYL--DKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASE 319
            ..:|  ::...:.:..:.|:.:....|..|||||.||:|..::..:..|.|     .:.:..|..
Mouse   150 VCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALIEVPDG-----FTAVMSADT 209

  Fly   320 YVDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVE--KTQYALDTAA 382
            :......:..|..:.|:.:||.|..:.|....|.....     :|:|.|..:|  |.:|     :
Mouse   210 WEKRGPNKFFFQMSHPIPSYLIALAIGDLASAEVGPRS-----RVWAEPCLIEAAKEEY-----S 264

  Fly   383 GVMAYYI----NYFNVSYALPKLDLVAI-PDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRV 442
            ||:..::    ..|. .|...:.||:.: |.|..|.||| ..:||....||        ...:.:
Mouse   265 GVIEEFLATGEKLFG-PYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPCLL--------AGDRSL 319

  Fly   443 AIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVL--- 504
            |.|:.||::|.|||||||...|.:.||||||..:.:                   ..:..:|
Mouse   320 ADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQ-------------------RRISTILFGA 365

  Fly   505 --------TIDATLASHPIVKSIESP-----------AEITEYFDTITYSKGAALVRMLENLVGE 550
                    |..|.|..|..|...|:|           .:..:.::...|.||...|..|.:|||:
Mouse   366 AYTCLEAATGRALLRQHMNVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGD 430

  Fly   551 ----EKLRNATTRYLVRHIYSTATTEDYL------------TAVEEEEGLEFDVKQIMQTWTEQM 599
                :|...|   |:....:.:...||:|            ..|:...|.|||      .|....
Mouse   431 QDQFDKFLKA---YVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFD------RWLNTP 486

  Fly   600 GLP--VVEVEKSGSTYK----LTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQSLI 658
            |.|  :.::....|..|    |.:....:..|..|.||.|.|   .|.   ||         .|:
Mouse   487 GWPPYLPDLSPGDSLMKPAEELAELWVTSEPDMQAIEAVAIS---TWK---TY---------QLV 536

  Fly   659 FNHNDNEATITLPE------EASWIKINTNQVGYYRVNYGSEQWAELISALKNS-RETFSTADRA 716
            :..:.......||.      ..::.||:..|....|:     :|.::|  |||. :|.|...
Mouse   537 YFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRL-----RWGQII--LKNDYQEEFQKV--- 591

  Fly   717 HLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVY---YTDLYTNYTTY 778
                 .:.|.:.|:..|::.|           |.....|:....||....:   .:.|::|...|
Mouse   592 -----KDFLQSQGKQKYTLPL-----------YHAMMGGSEMARTLAKDTFAATASQLHSNVVNY 640

  Fly   779 ARKLLTP 785
            .:::|.|
Mouse   641 VQQILAP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	98/440 (22%)
		M1_APN_2	151..602	CDD:189008	118/521 (23%)
		ERAP1_C	677..992	CDD:288671	24/113 (21%)
Rnpep	NP_663392.2	leuko_A4_hydro	24..634	CDD:274120	153/707 (22%)
		M1_LTA4H	24..484	CDD:189006	117/516 (23%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244	35/180 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810