DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and ENPEP

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	992	Identity:	381/992 - (38%)
Similarity:	568/992 - (57%)	Gaps:	64/992 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FCV---FLLVLCGFLLGALVYVGKNIAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTKPIIS 102
            :|:   .:.:||..::|..:.||..:                  ...|:.....|....|.|..|
Human    12 YCIQTKHVAILCAVVVGVGLIVGLAV------------------GLTRSCDSSGDGGPGTAPAPS 58

  Fly   103 VLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYS 167
            .|..:....:..|...:.     :.||.:..|...:|  ||||..:.|..|.||::|.||...|:
Human    59 HLPSSTASPSGPPAQDQD-----ICPASEDESGQWKN--FRLPDFVNPVHYDLHVKPLLEEDTYT 116

  Fly   168 GNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPLKD-ITPTLTFAHPEFEYWVTEFEQP 231
            |.:|||:.:..|..::.:|:::..::     ||.|...|..| :.....|.:.:.||.|.|.|:.
Human   117 GTVSISINLSAPTRYLWLHLRETRIT-----RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEE 176

  Fly   232 LEA----GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPAL 292
            |..    |.|.|.:.|.|.|...:.|.|:::|.:  ..:.:||::|..|||.||::|||||||..
Human   177 LTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE--NGQVKSIVATDHEPTDARKSFPCFDEPNK 239

  Fly   293 KAQFTITVARPSGDEYHVLSNMPVA-SEYVDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVE 356
            ||.:||::..|.  ||..||||||| .|.||...|..||.::|||||||..|.|..|. ....:.
Human   240 KATYTISITHPK--EYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFD-SVKRIS 301

  Fly   357 GTSIALKVYAPPAQVEKTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVT 421
            .:...|.:|..|.|....:||.:....|..|:..||.::|:|||||.:|||||.:||||||||:|
Human   302 NSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLIT 366

  Fly   422 FRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMH 486
            :|||.||||...|:|.|:||||.||||||.||||||:|||:||.|||||||||||.|:.||....
Human   367 YRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAE 431

  Fly   487 PEWDMDNQFVIEELHPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEE 551
            .:|.|.:|.::|::.||...|:.::||||:.::.:|.|||..||.|:||||::::||||:.:..|
Human   432 TDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPE 496

  Fly   552 KLRNATTRYLVRHIYSTATTEDYLTAVEEEEGLEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLT 616
            ..:.....||.::.:..|.|.|:..|:||...|  .||::|.|||.|||.||:.|   .....:|
Human   497 NFQKGCQMYLEKYQFKNAKTSDFWAALEEASRL--PVKEVMDTWTRQMGYPVLNV---NGVKNIT 556

  Fly   617 QKRFLANEDDYAAEAE-ASSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITL----PEEASW 676
            |||||.  |..|..:: .|...|.|:||:.:|.  ::...|::||.::.|. |||    |...::
Human   557 QKRFLL--DPRANPSQPPSDLGYTWNIPVKWTE--DNITSSVLFNRSEKEG-ITLNSSNPSGNAF 616

  Fly   677 IKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLIS 741
            :|||.:.:|:|||||....|..:.:||..:.:|||:||||.|::||..||.|..|:|.|||:|..
Human   617 LKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTK 681

  Fly   742 YLESEQDYVPWSVGTSALATLRNRVYYTD--LYTNYTTYARKLLTPIVEKVTFTVAADHLENRLR 804
            ||:.|::::||....||:..:.: ::..|  ||.....|.:..:.||.:.:.:..|.||:...||
Human   682 YLKREENFLPWQRVISAVTYIIS-MFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLR 745

  Fly   805 IKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLD 869
            ..||..||.:|...:|..|.:||.|||....:.| .::|.:||.||:|....|.:|:...:.|..
Human   746 SSVLGFACKMGDREALNNASSLFEQWLNGTVSLP-VNLRLLVYRYGMQNSGNEISWNYTLEQYQK 809

  Fly   870 ESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVREN 934
            .|.||||.||:..|.:|:...||.||::...|.:.::.||.||::.|||.|..|:::.|::::.|
Human   810 TSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLN 874

  Fly   935 WEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKW 999
            |:.||:|:.:|.|.|||:: ||...|:||.:|.:|:.||||||:||||...|:|.||.||.||:|
Human   875 WDYLVNRYTLNNRNLGRIV-TIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEW 938

  Fly  1000 LAANKAQVGEWLANYVQ 1016
            |..::..:.||..|.::
Human   939 LKQHRNTIREWFFNLLE 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	178/399 (45%)
		M1_APN_2	151..602	CDD:189008	199/456 (44%)
		ERAP1_C	677..992	CDD:288671	125/316 (40%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83		8/43 (19%)
		Peptidase_M1	92..482	CDD:279741	178/399 (45%)
		M1_APN_2	100..545	CDD:189008	199/456 (44%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		3/3 (100%)
		ERAP1_C	617..931	CDD:288671	125/316 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158475
Domainoid	1	1.000	242	1.000	Domainoid score	I2231
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	658	1.000	Inparanoid score	I777
Isobase	1	0.950	-	0	Normalized mean entropy	S1872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm40383
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740