DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and Npepps

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	905	Identity:	310/905 - (34%)
Similarity:	474/905 - (52%)	Gaps:	62/905 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 LQNLGF----------RLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFIPVHVKQLN 191
            |.:||.          |||.::.|..|.|.|:|||....:.|.:..:.||.:.       ..|:.
Mouse    38 LHSLGLAAMPEKRPFERLPAEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQA-------TNQIV 95

  Fly   192 VSTVEVKRLDESGAPLKD--ITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGM 254
            ::..::..:..|.||..|  |..|......|.|.....|...|:.|..:|.::|.|.|.|::.|.
Mouse    96 MNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGF 160

  Fly   255 YQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASE 319
            |:|.|... ....|....|:||.|.||:||||:||||:||.|.|::..|.  :...||||.|...
Mouse   161 YRSRYTTP-AGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPK--DRVALSNMNVIDR 222

  Fly   320 --YVDGD-ITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQYALDTA 381
              |.|.: :.||.||.|..|||||.||||.::.:.||..: ..:.::||.|..:.|:.::||:.|
Mouse   223 KPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSK-DGVCVRVYTPVGKAEQGKFALEVA 286

  Fly   382 AGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVV 446
            |..:.:|.:||||.|.|||:||:||.||.:||||||||||:||||||.|...|.|.::|.||:||
Mouse   287 AKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVV 351

  Fly   447 AHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLA 511
            .||||||||||||||.||..|||||||||::||..|....||:|:..|||..:......:||...
Mouse   352 GHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDN 416

  Fly   512 SHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLT 576
            ||||..|:..|:|:.|.||.|:|||||:::|||.:.:|::..:.....||.:.....|.|||...
Mouse   417 SHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE 481

  Fly   577 AVEEEEGLEFDVKQIMQTWTEQMGLPVVEVE----KSGSTYKLTQKRFLANEDDYAAEAEASSFN 637
            ::|...|.  .:..:|.|||:|||.|::.||    :.....||:||:|.|: ..|..|...
Mouse   482 SLESASGK--PIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCAS-GPYGGEDCP---- 539

  Fly   638 YRWSIPITYTSSINSEVQSLIFNHNDNEATITL----PEEASWIKINTNQVGYYRVNYGSEQWAE 698
             :|.:|||.::|.:.....|....:..|.::.|    |::  |:|:|...||:||..|.|.....
Mouse   540 -QWMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQ--WVKLNLGTVGFYRTQYSSAMLES 601

  Fly   699 LISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLR 763
            |:..:::.  :....||..|.||..:||.||.::....|.::....:|.:|..||..:..|..|.
Mouse   602 LLPGIRDL--SLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILS 664

  Fly   764 NRVYYTDLYTNYTTYARKLLTPIVEKVTF--TVAADHLENRLRIKVLSSACSLGHESSLQQAVTL 826
            ..:.:||.|.....:.:.:.:||.|::.:  .....||:..||..||......||:::|::|...
Mouse   665 TLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRR 729

  Fly   827 FNQWLASPETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWL 891
            |.:.:...:.. :.|:|..||...|:. ...|..|.:.||:......:||.::...|.|...|.|
Mouse   730 FKEHVEGKQIL-SADLRSPVYLTVLKH-GDGATLDIMLKLHKQADMQEEKNRIERVLGATLSPEL 792

  Fly   892 LQRYINWAWDESNVRRQDYFTLLGYIS-TNPVGQSLVWDYVRENWEKLVDRF--GINERTLGRLI 953
            :|:.:.:|..| .||.||..:::|.:: .:..|:...|.::::|||:|.:|:  |.   .:.|||
Mouse   793 IQKVLTFALSE-EVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRYQGGF---LISRLI 853

  Fly   954 PTITARFSTETKLEEMQQFFAKYPEAGAGTAAR--QQALEAVKANIKWLAANKAQVGEWL 1011
            ......|:.:....|::.||..:|   |.:|.|  ||..|.:..|..||..:...:.::|
Mouse   854 KLSVEGFAVDKMAGEVKAFFESHP---APSAERTIQQCCENILLNAAWLKRDADSIHQYL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	173/398 (43%)
		M1_APN_2	151..602	CDD:189008	191/455 (42%)
		ERAP1_C	677..992	CDD:288671	86/321 (27%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	173/398 (43%)
		M1_APN_2	62..505	CDD:189008	191/455 (42%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	86/321 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820