DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and AC3.5

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001256214.1	Gene:	AC3.5 / 179447	WormBaseID:	WBGene00007071	Length:	1090	Species:	Caenorhabditis elegans

Alignment Length:	1068	Identity:	249/1068 - (23%)
Similarity:	450/1068 - (42%)	Gaps:	167/1068 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 AAFCVFLLVLCGFLLGALVYVGKNIAEEHQRQ---QHANASQWALNSTIRTVYVDRDQLLSTKPI 100
            :|.|:|||.:...:..|  ::|..:.:::...   :.||.|.....:..|:....:|       |
Worm    79 SAICLFLLAVAAIIFAA--FLGHYLTKQNYEMMQFKSANESMTTCKNFTRSHKKHQD-------I 134

  Fly   101 ISVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKN 165
            ::....:...:.:.||.::                      ..|||.::|..|.:.|.|.:....
Worm   135 VNEEDADENASIKQPTKEE----------------------LALPKNVQPVWYDVSLSPKVGGNG 177

  Fly   166 YSGNISISLQVLEPIAFIPVHVKQLNVS------------TVEVKRLDESG-------------- 204
            ..|...:.|.:.||...|.::.|.:..:            |...|:..:||
Worm   178 TMGLAHVKLNIEEPTNKIVLNAKDIEFTRNLEKIQLSKEVTKRAKKSVDSGTNSTSEMPEGSGEE 242

  Fly   205 --------APLKDITPTLTFAHPEFEYWVTEFEQPLE------------AGNYSLLLNFTGSLVD 249
                    ...:..||..:|.....:....||::.||            .....|.:.|| |.|.
Worm   243 AMATTATTTTTESTTPVSSFVDTGIKVTNIEFDENLEKVTLTLDQELKKGSTVVLKIPFT-SKVS 306

  Fly   250 RITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNM 314
            ...|:.:..|.:. :.:.:|:.:|:...:|.|..||.||:.|.||...||:....|.  .|::|.
Worm   307 NNNGLKEYKYKNS-EGKEQSMFTTQPSYSYLRHVFPSFDQEAFKAPAAITLMHSKGS--IVVANT 368

  Fly   315 PVASEYVDGDITEVTFAETVPMSTYL-AAFVVSDFQYKETTVEGTS-IALKVYAPPAQVEKTQYA 377
            .|.:: .|||      |:|..::..| ..||:.|....|  |..|| |.::::..|.....|:.:
Worm   369 GVKTK-DDGD------AQTSTLNKVLDPDFVIGDLVASE--VNTTSGITIRIWTRPEVKHSTEQS 424

  Fly   378 LDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRV 442
            ||.|...:....:..........||:||:|.|.:|...:...:...|..:||:|.::....|.|:
Worm   425 LDYANQAIDAMEHILQSRLESKSLDIVAVPGFQTGNRVSPSFIVLPEEDILYNEQSNDINQKTRI 489

  Fly   443 AIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFV-IEELHPVLTI 506
            |.::::.:|.||||.:.....:...||||....|||.:.::::   .|:::..: ..|:..:|..
Worm   490 ARMISNRIAAQWFGGITNPEEFGTFWLNEALPRFLEVEALEKI---LDINSDDLWTYEMEKILER 551

  Fly   507 DATLASHPI-VKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTAT 570
            |||..|.|: ||::.|.|:|.|........||||::||::..||......|     :|...|:
Worm   552 DATATSQPLRVKNVFSSADIAEIDHEFIGKKGAAVLRMIQKSVGVNVFNKA-----IRSFVSS-- 609

  Fly   571 TEDYLTAVEEEEGL------------------EFDVKQIMQTWTEQMGLPVVEVEK-SGSTYKLT 616
               |.:|...::||                  ..||.:.:.||.:|:|.|:|.||| ...|.:|:
Worm   610 ---YRSAYPYDDGLWKSFEKALGGKLKGWNNEPLDVAKFVNTWVDQIGFPLVSVEKLDDETVELS 671

  Fly   617 QKRFLANEDDYAAEAEASSFN----YRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEAS-W 676
            |:||   ::|:..:.:....|    :.|.:|:...||  ..|.::.:.|.    ...||...| .
Worm   672 QERF---KNDHKTKEQFKFRNAKYWFNWEVPLFLKSS--GPVGNVSWLHE----AFRLPLNTSDS 727

  Fly   677 IKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLIS 741
            |.:||:..|.|||||..::|.::...|:.|....|...||.|::|...||.:|.|.:..||::.|
Worm   728 IYLNTDSNGVYRVNYEEKRWNDIAKQLEKSHGKLSERTRARLISDVFALANSGALPFETALNVTS 792

  Fly   742 YLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTPIVEKVTFT---VAADHLENRL 803
            ||..|...|||.:.|.....|..|:....:.....::..:.:....|:::.:   .::::|:|||
Worm   793 YLPMETATVPWLIATRIFKKLTERLEGAPIQDKLNSFIYQKIHKKFEEISSSPGEASSNYLKNRL 857

  Fly   804 RIKVLSSACSLGHESSLQQAVTLFNQWLASP---------ETRPNP-DIRDVVYYYGLQQVNTEA 858
            ...:|.....:..|.|.::...||.:...:|         :....| |:|:.||..|::..| :.
Worm   858 YANLLDLMAIVKPEKSNEKLNELFVEGFLAPCQFSGNFSSDCSEVPGDLREKVYCNGVEFGN-DT 921

  Fly   859 AWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFT-LLGYISTNPV 922
            .::.|.:|...|.|..||..|.|.|...:.|..|:|.|     ..|:......| ||..:::.||
Worm   922 VFETVRELAEKEVDGAEKDLLQNSLACFRDPRALRRLI-----LDNLNSTSTVTLLLRKMNSRPV 981

  Fly   923 GQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQ 987
            |:.:..:::.:||..::.:...|:......|.........|.:...::.|...:.::..|..:..
Worm   982 GKEIATNWIIDNWSTVLKKKFKNDPETLNAIADAGIILDNEREKSMIETFMEHHHKSTHGIESLD 1046

  Fly   988 QALEAVKANIKWLAANKAQVGEWLANYV 1015
            :.:|....:|.|   .|.::.| |.:|:
Worm  1047 KKIEEATTDIYW---RKQKINE-LNDYL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	107/443 (24%)
		M1_APN_2	151..602	CDD:189008	124/518 (24%)
		ERAP1_C	677..992	CDD:288671	78/328 (24%)
AC3.5	NP_001256214.1	Peptidase_M1	156..574	CDD:279741	106/433 (24%)
		GluZincin	165..656	CDD:301352	124/516 (24%)
		ERAP1_C	728..1052	CDD:288671	79/329 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020