DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and Lnpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	331/907 - (36%)
Similarity:	497/907 - (54%)	Gaps:	38/907 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPIAFI 183
            |::..|.:...:....||......|||..|.|.:|.|.|.|:|....:.|:::||||.|:....|
  Rat   143 KTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDI 207

  Fly   184 PVHVKQLNVSTVEVKRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLV 248
            .:|....|:|:|.......|.....:|   |.:.:.| :..|...|..|...||:|.:.::.::.
  Rat   208 ILHSTGHNISSVTFMSAVSSQEKQVEI---LEYPYHE-QIAVVAPESLLTGHNYTLKIEYSANIS 268

  Fly   249 DRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYH-VLS 312
            :...|.|..:|.|| .|..::..:|:|||..||.|||||||||.||.|.|.:.|   ||:| .||
  Rat   269 NSYYGFYGITYTDK-SNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITR---DEHHTALS 329

  Fly   313 NMPVASEY-VDGDITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVEKTQY 376
            |||..|.. .:..:.:..|:|:|.|||||.||:|.:.:.....|.||.::  |||.|.::::..:
  Rat   330 NMPKKSSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVS--VYAVPEKIDQVYH 392

  Fly   377 ALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQR 441
            ||||...::.:|.|||.:.|.|.||||||||||.:||||||||:||||..||||.:|||..:::.
  Rat   393 ALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATSSVADRKL 457

  Fly   442 VAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTI 506
            |..::|||||||||||||||.||||||||||||:|:||..|:::..|.:....| ::.....:..
  Rat   458 VTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSYEDF-LDARFKTMRK 521

  Fly   507 DATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATT 571
            |:..:||||..|::|..:|.|.||:::|.|||:|:.||::.:.|:..::|...||..|.|:...:
  Rat   522 DSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQS 586

  Fly   572 EDYLTAVEEEEGLEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSF 636
            :|...:..|..|...|||::|:|||.|.|.|:|.|::.|:...|.|:||..:   ...|.:.|..
  Rat   587 DDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRKGTELLLQQERFFPS---MQPEIQDSDT 648

  Fly   637 NYRWSIPITY-TSSIN-SEVQ--SLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWA 697
            ::.|.|||:| |...| ||.:  ||:...:|   .|.|.|:..|:|:|||..|||.|:|..:.||
  Rat   649 SHLWHIPISYVTDGRNYSEYRSVSLLDKKSD---VINLTEQVQWVKVNTNMTGYYIVHYAHDGWA 710

  Fly   698 ELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVG---TSAL 759
            .||:.||.:....|..|||:|:|:...||..|::...:|.|||.||.:|....|.:..   |..:
  Rat   711 ALINQLKRNPYVLSDKDRANLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLI 775

  Fly   760 ATLRNRVYYTDLYTNYTTYARKLLTPIVEKVTFTVAADHLENRLRIKVLSSACSLGHESSLQQAV 824
            ..|..::.:.||.:...|...|||...:::.|:|.........||..:|..||:...|:....|.
  Rat   776 YNLLEKLGHMDLSSRLVTRVHKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMAT 840

  Fly   825 TLFNQWLASPETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLT---- 884
            .||:.|:||..|:..| |:...|:..|   ..||..|..::.:|.......||.|::..|.
  Rat   841 KLFDGWMASNGTQSLPTDVMTTVFKVG---ARTEKGWLFLFSMYSSMGSEAEKDKILEALASSAD 902

  Fly   885 AVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTL 949
            |.::.||::..:    |...:|.|....::..:.....|..|.||:|:|||.|||.:|.:...|:
  Rat   903 AHKLYWLMKSSL----DGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTI 963

  Fly   950 GRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQALEAVKANIKWLAANKAQVGEWL 1011
            ..::...|..|||:|.|.|:|:||....||.......|:|.|.::.||:|:|.|...:..||
  Rat   964 QSIVAGSTHLFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	169/395 (43%)
		M1_APN_2	151..602	CDD:189008	188/452 (42%)
		ERAP1_C	677..992	CDD:288671	100/322 (31%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	169/395 (43%)
		M1_APN_2	176..617	CDD:189008	188/451 (42%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	100/321 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820