DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and Lta4h

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_032543.2	Gene:	Lta4h / 16993	MGIID:	96836	Length:	611	Species:	Mus musculus

Alignment Length:	621	Identity:	155/621 - (24%)
Similarity:	240/621 - (38%)	Gaps:	148/621 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LHLR--PDLERKNYSGNISISLQVLEP-IAFIPVHVKQLNVSTV-----EVK-RLDES----GAP 206
            ||||  .|..|:..:|..::::|..|. :..:.:..|.|.:..|     ||| .|.||    |:|
Mouse    22 LHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSP 86

  Fly   207 LKDITPTLTFAHPEFEYWVTEFEQPLEAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSII 271
            ::...|.....:.|.     ..|...|....|..|.:   |....|...|..||
Mouse    87 MEISLPIALSKNQEI-----VIEISFETSPKSSALQW---LTPEQTSGKQHPYL----------- 132

  Fly   272 STKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSNMPVASEYVDGDITE--------V 328
            .::.:..:.|...||.|.|::|..:|..|:.|.       ..:.:.|...||:..:        .
Mouse   133 FSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPK-------ELVALMSAIRDGEAPDPEDPSRKIY 190

  Fly   329 TFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALK--VYAPPAQVEK-------TQYALDTAAGV 384
            .|.:.||:..||.|.||.       .:|...|..:  |::...||||       |:..|..|..:
Mouse   191 RFNQRVPIPCYLIALVVG-------ALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDL 248

  Fly   385 MAYYINYFNVSYALPKLDLVAI-PDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAH 448
            ...|:        ..:.||:.: |.|..|.|||..|.....|.|..|:|.|:         |:||
Mouse   249 GGPYV--------WGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSN---------VIAH 296

  Fly   449 ELAHQWFGNLVTMNWWNDLWLNEGFASFLEYK------GVKQMH----PEW-DMDNQFVIEELHP 502
            |::|.|.|||||...|:..|||||...:||..      |.|..|    ..| ::.|
Mouse   297 EISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQN--------- 352

  Fly   503 VLTIDATLASHPIVKSIESPAEITE--YFDTITYSKGAALVRMLENLV-GEEKLRNATTRYLVRH 564
              ||.....|||..|.:....::..  .:.:|.|.||.||:..||.|: |.|........|:.:.
Mouse   353 --TIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKF 415

  Fly   565 IYSTATTEDYLTAVEEEEGLEFD-VKQI-MQTWTEQMGLPVV----EVEKSGSTYKLTQKRFLAN 623
            .|.:.||:|:.:.:......:.| :.|: ..||....|||.|    :|..:.:...|:|:...|.
Mouse   416 SYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAK 480

  Fly   624 EDDYAAEAEASSFNYRWSIPITYTSSINSEVQSLIFNHNDNEATITLPEEA----SWIK-----I 679
            |:|      .|||:.             ::::.| .:|..||....:.::|    ..||     .
Mouse   481 EED------LSSFSI-------------ADLKDL-SSHQLNEFLAQVLQKAPLPLGHIKRMQEVY 525

  Fly   680 NTNQVGYYRVNYG------SEQWAELIS-ALKNSRE 708
            |.|.:....:.:.      ..:|.|.|. |||.:.|
Mouse   526 NFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATE 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	108/425 (25%)
		M1_APN_2	151..602	CDD:189008	127/493 (26%)
		ERAP1_C	677..992	CDD:288671	11/44 (25%)
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	155/621 (25%)
		M1_LTA4H	6..450	CDD:189006	126/488 (26%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	135..137		0/1 (0%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	24/114 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	564..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810