DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and Anpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	1037	Identity:	342/1037 - (32%)
Similarity:	531/1037 - (51%)	Gaps:	139/1037 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ILTLAAFCVFLLVLCGFLLGALVYVGKNIAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTKP 99
            :|.:||.|..:.:       ::||     |:|..|.        |.||             :|.|
Mouse    17 LLGVAAVCTIIAL-------SVVY-----AQEKNRN--------AENS-------------ATAP 48

  Fly   100 IISVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLERK 164
            .:             |.| .|:..||..|||..:....|   :||||.:.|..||:.|||.|...
Mouse    49 TL-------------PGS-TSATTATTTPAVDESKPWNQ---YRLPKTLIPDSYRVILRPYLTPN 96

  Fly   165 N-----YSGNISISLQVLEPIAFIPVHVKQLNVS-----TVEVKRLDESGAPLKDITPTLTFAHP 219
            |     :.||.::.....:....|.:|.|:||.:     .|.::.||.:.||..|.|..:    .
Mouse    97 NQGLYIFQGNSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVLRTLDGTPAPNIDKTELV----E 157

  Fly   220 EFEYWVTEFEQPL-EAGNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQA 283
            ..||.|...:..| |...|.:...|.|.|.|.:.|.|:|.|::  .:..:.:.:|:.:...||::
Mouse   158 RTEYLVVHLQGSLVEGRQYEMDSQFQGELADDLAGFYRSEYME--GDVKKVVATTQMQAADARKS 220

  Fly   284 FPCFDEPALKAQFTITVARPSGDEYHVLSNM-PVASEYV--DGDITEVTFAETVPMSTYLAAFVV 345
            ||||||||:||.|.||:..|  :....|||| |..|:..  |...|...|..|..|||||.|::|
Mouse   221 FPCFDEPAMKAMFNITLIYP--NNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIV 283

  Fly   346 SDFQYKETTVEGTSIALKVYAPPAQVEKTQ--YALDTAAGVMAYYINYFNVSYALPKLDLVAIPD 408
            |:|: ..::|....:.:.::|.|:.:::.|  |||:....::.::..::|.||.|||.|.:|:||
Mouse   284 SEFK-NISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSYPLPKSDQIALPD 347

  Fly   409 FVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGF 473
            |.:||||||||||:||::|::|..:||..||:||..|:||||||||||||||:.|||||||||||
Mouse   348 FNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGF 412

  Fly   474 ASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI---VKSIESPAEITEYFDTITYS 535
            ||::||.|.....|.|::.:..|:.:::.|:.:||..:|||:   ...|::|.:|.|.||:||||
Mouse   413 ASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYS 477

  Fly   536 KGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATT------EDYLTAVEEEEGLE--FDVKQIM 592
            |||:::|||.:.:.|:..:...:.||  |.|..:.|      |....||.::..::  ..|:.||
Mouse   478 KGASVIRMLSSFLTEDLFKKGLSSYL--HTYQYSNTVYLDLWEHLQKAVNQQTAVQPPATVRTIM 540

  Fly   593 QTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSE---- 653
            ..|..|||.||:.|  :.:|.:::||.||.  |..:.....|.|||.|..||.:..|...:
Mouse   541 DRWILQMGFPVITV--NTNTGEISQKHFLL--DSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWL 601

  Fly   654 ----VQSLIFNHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTAD 714
                .||..|..:.||          ||.:|.|..|||.|||....|.:|.:.|:.........:
Mouse   602 DVEKNQSAKFQTSSNE----------WILLNINVTGYYLVNYDENNWKKLQNQLQTDLSVIPVIN 656

  Fly   715 RAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYT------DLYT 773
            ||.:::|:..||:|..:..::|||...:|..|.:|:||....|:|.      |:|      ::|.
Mouse   657 RAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLN------YFTLMFDRSEVYG 715

  Fly   774 NYTTYARKLLTPIVEKVTFTVAADHLENR--------LRIKVLSSACSLGHESSLQQAVTLFNQW 830
            ....|.:|.:||:.  ..|....::..||        ..|..:|:|||.|.:......|.|::||
Mouse   716 PMKRYLKKQVTPLF--FYFQNRTNNWVNRPPTLMEQYNEINAISTACSSGLKECRDLVVELYSQW 778

  Fly   831 LASPETRP-NPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQR 894
            :.:|.... :|::|..||...: ....|..|:..|:.:.:.:...|..||.:.|...:..|:|.|
Mouse   779 MKNPNNNTIHPNLRSTVYCNAI-AFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNR 842

  Fly   895 YINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITAR 959
            |:::..:...:|:||..:.:..|::|..|..||||:||.||:||.:.:|....:...||..:|.|
Mouse   843 YLSYTLNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRR 907

  Fly   960 FSTETKLEEMQQFFAKYPEAGAGTAAR--QQALEAVKANIKWLAANKAQVGEWLANYVQQSS 1019
            ||:|.:|::::||.|.....|.||..|  :||||..:|||.|:..||..|.:|   :.:.||
Mouse   908 FSSEFELQQLEQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKW---FTENSS 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	164/412 (40%)
		M1_APN_2	151..602	CDD:189008	181/477 (38%)
		ERAP1_C	677..992	CDD:288671	99/331 (30%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		17/74 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		9/48 (19%)
		Metalloprotease	69..966		318/936 (34%)
		M1_APN-Q_like	84..545	CDD:341064	178/471 (38%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	101/335 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3793
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850