DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and erap1

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_002933475.2	Gene:	erap1 / 100496768	XenbaseID:	XB-GENE-983344	Length:	932	Species:	Xenopus tropicalis

Alignment Length:	933	Identity:	340/933 - (36%)
Similarity:	493/933 - (52%)	Gaps:	69/933 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IMATVAPAVKAASKVLQNL------GFRLPKQIKPSKYRLHLRPDLERKNYSGNISISLQVLEPI 180
            |..::.||: ||||.|.|.      ..|||....|..|.|.:.|:|....:||...:::.|.:..
Frog    26 ISFSIQPAL-AASKALDNAEMFPWKNLRLPTFAAPLHYDLLIHPNLTTLTFSGLTKVTVTVTQKT 89

  Fly   181 AFIPVHVKQLNVSTVEVKRLDESGAPLKDITPTLTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFT 244
            :|:.:|.|.|.::...:||.......|:|:   |...||..|........||..| ||::.:.:.
Frog    90 SFLVLHSKHLEITKTTIKRKLGKDPVLQDL---LLREHPVNEQIALLAADPLIPGENYTIYIEYN 151

  Fly   245 GSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYH 309
            .:|.....|.|:|:|..| ....|.:.||:||||.||.|||||||||.||.|:|.:.|.  .::|
Frog   152 ANLSKNFRGFYKSTYKTK-DGEVRVLASTQFEPTAARTAFPCFDEPAFKASFSIQIRRE--PKHH 213

  Fly   310 VLSNMPVASEY-VDGDITEVTFAETVPMSTYLAAFVVSDFQ-YKETTVEGTSIALKVYAPPAQVE 372
            .:|||||.... :.|.:.|..||.:|.|||||.||:||||: ..:.|..|  :.:.|||.|.:::
Frog   214 AVSNMPVVKTVNIGGGLLEDHFAASVKMSTYLVAFIVSDFKSISQVTNHG--VRISVYATPEKID 276

  Fly   373 KTQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSV 437
            :.:|||..|..::.:|.:|||:||.|||.||.|||||.|||||||||.|:||:|||:|..||::.
Frog   277 QAEYALKAAVKLLDFYEDYFNISYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLHDPKTSTAS 341

  Fly   438 NKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHP 502
            :|..|.:::|||||||||||||||.||||||||||||.|:||..|:..:||..:::.| :::...
Frog   342 HKLWVTMIIAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEYVSVRVTYPELQVEDYF-LDKCFR 405

  Fly   503 VLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYS 567
            .:.:|:..:||.:...:|:|.||.|.||.::|.|||.::.||.:.:|.|........||.|:.|.
Frog   406 AMDVDSLNSSHAVSTPVENPEEIQEMFDEVSYDKGACILNMLMDYMGAESFEAGIVDYLRRYSYR 470

  Fly   568 TATTED-----------------YLTAVEE----EEGLEFDVKQIMQTWTEQMGLPVVEVEKSGS 611
            .|..||                 |.|...:    .||...|||.:|.|||.|.|.|:|.|...|.
Frog   471 NARNEDLWNSMTDVCPSDETNSGYCTKTRQTSHWSEGEIIDVKSMMNTWTLQKGFPLVTVTVKGK 535

  Fly   612 TYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEVQS-LIFNHNDNEATITLPEEAS 675
            ...|.|:.:|....|    .|||..  .|.||:||.:|.::.||. |:.:..|   .:.|.||..
Frog   536 YVYLHQEHYLKGSTD----TEASGL--LWHIPLTYITSKSNTVQRFLLMSKTD---VLVLAEEVE 591

  Fly   676 WIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLI 740
            |||.|....|||.|:|..|.|..||..|:.:....|:.|||:|:|.|..|.:.|:|....||.|.
Frog   592 WIKFNVGMNGYYIVHYEGEGWDALIKLLQENHTAISSNDRANLINSAFQLVSIGRLPIDKALSLS 656

  Fly   741 SYLESEQDYVPWSVGTSALATLRNRVYYTDLY---TNYTTYARKLLTPIVEKVTFTVAADHLENR 802
            .||::|...:|...|...|..:...:...|:.   :....|...||..:::..::|......|..
Frog   657 LYLKNEDKIMPVFQGMDELIPIYKLMEKRDMQEVESQMKKYILNLLRKLIDAQSWTDEGSVSERM 721

  Fly   803 LRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNP-DIRDVVYYYGLQQVNTEAAWDQVWKL 866
            ||..:|..||...::..:|:|...|.:|..|..|...| |:...||..|.|   |...||.:::.
Frog   722 LRSSLLLFACVRQYQPCVQRAEQYFKRWQESNGTISLPRDVASAVYAVGAQ---TPEGWDFLFEK 783

  Fly   867 YLDESDAQEK--LKLMNCLTAVQVPWLLQRYINWAWDE----SNVRRQDYFTLLGYISTNPVGQS 925
            |.......||  ::|...:|:      |:..:.|..:|    .:||.||...::.|:|.||||..
Frog   784 YKTTLSGSEKNQIELALAITS------LKHKLQWLMEEGMKGDHVRTQDLPHIVLYVSRNPVGYP 842

  Fly   926 LVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAGTAARQQAL 990
            |.|::::.||..||.:|.:..||:|.::..||.::||:..|||:..||....|.|:.....|||.
Frog   843 LSWEFLKNNWGNLVQKFELGSRTVGDMVVGITKQYSTKEWLEEVTGFFDSLKEMGSQLRCVQQAR 907

  Fly   991 EAVKANIKWLAANKAQVGEWLAN 1013
            |.::.||:|:..|...|..||.|
Frog   908 ETIEENIRWMDKNLDLVKSWLEN 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	170/396 (43%)
		M1_APN_2	151..602	CDD:189008	193/474 (41%)
		ERAP1_C	677..992	CDD:288671	100/324 (31%)
erap1	XP_002933475.2	M1_APN-Q_like	60..521	CDD:341064	190/469 (41%)
erap1	XP_002933475.2	ERAP1_C	592..911	CDD:378732	102/327 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020