DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and anpep

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	347/968 - (35%)
Similarity:	516/968 - (53%)	Gaps:	87/968 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 KPIISVLSDNRFYTTQVPTSKKSSIMATVAPAVKAASKVLQNLGFRLPKQIKPSKYRLHLRPDLE 162
            ||..:..|.:...|....|:..::..||.|.:....:|      :||||.:.|..|.:.|:|.|.
Frog    45 KPPETTTSSSGTSTATTTTTATATATATTAQSNDPWNK------YRLPKTLSPVHYDVELQPFLV 103

  Fly   163 RKNYSGNISISLQVL--EPIAF---------IPVHVKQLN---VSTVEVKRLDESGAPLKDITPT 213
             ||..|     |.|.  :..||         |.:|..:||   .::.:.|..|  ||  .|:...
Frog   104 -KNADG-----LYVFRGKSTAFFICNDATDLIIIHSNKLNHTKFNSFDAKLQD--GA--TDVALK 158

  Fly   214 LTFAHPEFEYWVTEFEQPLEAG-NYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEP 277
            .||...:.::.|.:....|..| .|.|...|.|.|.|.:.|.|:|.||:  ...::.|.:|:.:.
Frog   159 STFFQKDKQFLVVQAAANLVPGKQYGLYTEFVGELADDLAGFYRSEYLE--DGVTKIIATTQMQA 221

  Fly   278 TYARQAFPCFDEPALKAQFTITV--ARPSGDEYHVLSNM-----PVASEYVDGDITEVT-FAETV 334
            ..||:|||||||||:||.|.||:  .:|    |..:|||     ...:|  ||....|: |.:|.
Frog   222 PDARKAFPCFDEPAMKATFNITLKYRQP----YKAMSNMREIDRSTVTE--DGQQWTVSKFDKTP 280

  Fly   335 PMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVE---KTQYALDTAAGVMAYYINYFNVSY 396
            .||:||.||:||:|:........|...::::.....::   :.:|||.....::.::..|:...|
Frog   281 KMSSYLVAFIVSEFEAVGDPGNATVTGVQIWGRKKAIQDENQGEYALSVTKPILDFFAEYYRTPY 345

  Fly   397 ALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTM 461
            .|||.|.||:|||.:||||||||||:||||||:|:..||..||:||..|:||||||||||||||:
Frog   346 PLPKSDQVALPDFSAGAMENWGLVTYRETALLFDDQVSSIGNKERVVTVIAHELAHQWFGNLVTI 410

  Fly   462 NWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPIVK---SIESPA 523
            .|||||||||||||::||.|..:..|.|::.:..|:.::|.|:.:||..:|||:..   .:.||:
Frog   411 RWWNDLWLNEGFASYVEYLGADKAEPNWNIKDLIVLNDVHRVMAVDALASSHPLTSREDEVNSPS 475

  Fly   524 EITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTEDYLT----AVEEEEG- 583
            ||:..||:|.|||||:::|||...:.|....:....||....||.....|..|    ||..:..
Frog   476 EISALFDSIAYSKGASVIRMLSEFLTEPLFVDGLASYLKGFEYSNTVYSDLWTHLQWAVNNQTAV 540

  Fly   584 -LEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYT 647
             |...:|.||.||..|||.|||:::.  :|..:|||.||.:.|  :.....|.|:|:|.:||:|
Frog   541 KLPLPIKDIMDTWVLQMGFPVVKIDT--ATGVVTQKHFLLDPD--SVVTRPSPFDYKWKVPISY- 600

  Fly   648 SSINSEVQSLIFNHNDNEAT----ITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRE 708
             .|:|: :..|:..|::|..    ||   ...|:.:|.|..|||||||....|:.|::.|:.|.:
Frog   601 -KISSK-EDNIWLQNESETVEDFKIT---GNDWLLVNLNVTGYYRVNYDDNNWSRLLNQLQTSHQ 660

  Fly   709 TFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYT 773
            .....:||.:::||..||.|.|:....|||...|:.::::|:||....|.|:........|:::.
Frog   661 AIPVINRAQIIDDAFNLARAKQITTIQALDTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFG 725

  Fly   774 NYTTYARKLLTPIVEKVTFTVAADHLENR--------LRIKVLSSACSLGHESSLQQAVTLFNQW 830
            ....|.:..:.|:.|  .|.....:..||        ..|..||:|||...|..|:.|..||:||
Frog   726 PMKKYMKMQVNPLFE--YFKQETGNWTNRPVSLTDQYCEINTLSTACSYDIEDCLKFASELFSQW 788

  Fly   831 LASP-ETRPNPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQR 894
            :|:| :...:|::|..||...:.| ..|..|:.||..:.....|||:.||...|...:.||:|.|
Frog   789 MATPQQNNIHPNLRTNVYCTAVAQ-GGEQEWNFVWDRFQLTDIAQEQDKLRAALACSKEPWILNR 852

  Fly   895 YINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITAR 959
            ::.::.|.:.:||||..:.:..:..||:||||.||:||..|:.|...||.:..:.|.||..:|.|
Frog   853 FLEYSLDPTMIRRQDAVSTISSVVNNPIGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRR 917

  Fly   960 FSTETKLEEMQQFFAKYPEAGAGTA--ARQQALEAVKANIKWLAANKAQVGEWLANYV 1015
            ||||.:|:::.||.|.....|.|||  |.:||:|..||||.|:..|||.|.:|..:.|
Frog   918 FSTEFELQQLLQFKADNQNPGFGTASQALEQAIEKTKANINWVNQNKAAVKKWFEDAV 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	167/422 (40%)
		M1_APN_2	151..602	CDD:189008	186/485 (38%)
		ERAP1_C	677..992	CDD:288671	110/325 (34%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	183/480 (38%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	112/329 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110