DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32473 and trhde

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_002939988.3	Gene:	trhde / 100489066	XenbaseID:	XB-GENE-1013649	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	1011	Identity:	315/1011 - (31%)
Similarity:	518/1011 - (51%)	Gaps:	68/1011 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 IAEEHQRQQHANASQWALNSTIRTVYVDRDQLLSTK---------------PIISVLSDNRFY-- 110
            |.:...|.......|||....:||...:|...:..|               .||:||...||.
Frog    20 IEDTGMRNGRGLQDQWADTVAVRTRTTERQITVHRKLVLAFAISILALIVVTIIAVLLSVRFEEC 84

  Fly   111 ---TTQVPTSK--------------KSSIMATVAPAVKAASKVLQNLGF-RLPKQIKPSKYRLHL 157
               :|:|..|.              |.|...|..|.||...:..:...: |||..::|..|.|.:
Frog    85 TDGSTRVINSSILEAARFNQNLELDKDSGEGTQRPPVKDPEEEWKPWTYLRLPTHLRPLHYNLMV 149

  Fly   158 RPDLERKNYSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLDESGAPLKDITPTLTFAHPEFE 222
            ...:....:.|.:::.::.|....:|.||..:|.|..|:|.....:|    ::..:..|.:|:.:
Frog   150 TAFMNNFTFCGEVNVEIECLNSSRYIVVHAHRLTVERVQVAEDRVAG----EVKVSHYFPYPQNQ 210

  Fly   223 YWVTEFEQPLEA-GNYSLLLNFTGSLVDRITGMYQSSYLDKLKNRSRSIISTKFEPTYARQAFPC 286
            ..|....:.||| .:|:|.:.::..:.:.:.|.::|||:  |....||:..|:|.|.:||:||||
Frog   211 VLVVVLNRSLEAQKSYNLKIIYSAIIENELLGFFRSSYV--LHGERRSLAVTQFSPIHARKAFPC 273

  Fly   287 FDEPALKAQFTITVARPSGDEYHVLSNMPV-ASEYVDGDITEVTFAETVPMSTYLAAFVVSDFQY 350
            ||||..||.|.|::...:  .|..|||||| .|.:.:|......|::|..||||..|:.|.:|.:
Frog   274 FDEPIYKATFKISIRHQT--SYLSLSNMPVETSVFEEGGWVTDHFSQTPLMSTYYLAWAVCNFTF 336

  Fly   351 KETTVEGTSIALKVYAPPAQVEK--TQYALDTAAGVMAYYINYFNVSYALPKLDLVAIPDFVSGA 413
            ||...: :.:.:::||.|..:.:  ..|||:....::.:|.:||.|.|:||||||:|:|.....|
Frog   337 KEAVTQ-SGVVVRLYARPDAIRRGSGDYALNITKRLLEFYEDYFRVPYSLPKLDLLAVPKHPYAA 400

  Fly   414 MENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELAHQWFGNLVTMNWWNDLWLNEGFASFLE 478
            ||||||..|.|..:|.|.|.||......|.:|:.||:.|||||:|||..||.|:||.||.|.:.|
Frog   401 MENWGLSVFVEQRILLDPSISSISYLLDVTMVIVHEICHQWFGDLVTPIWWEDVWLKEGLAHYFE 465

  Fly   479 YKGVKQMHPEWDMDNQ-FVIEELHPVLTIDATLASHPIVKSIESPAEITEYFDTITYSKGAALVR 542
            :.|...::|.|:|:.| |:.:.||.|:.:|...:|||:.:.:....:|...||.|.|.|||||:|
Frog   466 FVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLKATDIDRVFDWIAYKKGAALIR 530

  Fly   543 MLENLVGEEKLRNATTRYLVRHIYSTATTEDY---LTAVEEEEGLEFDVKQIMQTWTEQMGLPVV 604
            ||.|.:|.:..:.....||..|.|..|...|.   ||.|.:.||...:::::|..||.|||.||:
Frog   531 MLANFMGHKVFQRGLQDYLTTHKYGNAARNDLWNTLTKVLKNEGKLLNIREVMDQWTLQMGYPVI 595

  Fly   605 EVEKSGST---YKLTQKRFLANEDDYAAEAEASSFNYRWSIPITYTSSINSEV--QSLIFNHNDN 664
            .:.::.:|   ..:||:.||.|.|....:.|..:.:..|.||:|......|.:  |::|:..|.:
Frog   596 TILRNDTTDDIITITQEHFLYNIDKRTRDKEFRNKSSLWQIPLTIAVGNTSHISPQAIIWVSNKS 660

  Fly   665 E-ATITLPEEASWIKINTNQVGYYRVNYGSEQWAELISALKNSRETFSTADRAHLLNDANTLAAA 728
            | ..|...:|::|:..|.:|:||:||||....|..|...|..:.|..|.::||.|::||..||.|
Frog   661 EYHRIPSLDESNWVLGNLDQIGYFRVNYDVRNWRLLTDQLMRNSEVISVSNRAALIDDAFNLARA 725

  Fly   729 GQLNYSVALDLISYLESEQDYVPWSVGTSALATLRNRVYYTDLYTNYTTYARKLLTPIVEKVTF- 792
            |.|..::.|::|.||..|:|::||...:.||..|...:..|:.|:.::.|..|.::.:..::.:
Frog   726 GYLTQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRTEDYSIFSEYILKQVSTMYFRLGWP 790

  Fly   793 -------TVAADHLENRLRIKVLSSACSLGHESSLQQAVTLFNQWLASPETRPNPDIRDVVYYYG 850
                   .|...:....||.:|:..|||.|::...|:|.|:.:.|::|...|..|::||:||..|
Frog   791 TNGQNGSAVPTSYQTEELRREVIMLACSFGNKQCHQKAATMISDWISSNRNRIPPNVRDIVYCTG 855

  Fly   851 LQQVNTEAAWDQVWKLYLDESDAQEKLKLMNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLG 915
            :..:: |..|:.:|..:...:...||..|:..||......||.|.:|.:.:...|..||...::.
Frog   856 VSLMD-EDVWEFIWMKFHSSTAVSEKKILLEALTCSDNRNLLNRLLNLSLNSEVVLDQDAIDVII 919

  Fly   916 YISTNPVGQSLVWDYVRENWEKLVDRFGINERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAG 980
            :::.||.|:.|.|.:.|:.|:.|..|:|.......:||..:|...:||.:|.|::.|..:: :.|
Frog   920 HVARNPHGRDLAWKFFRDKWKILNARYGEALFMNSKLISGVTEFLNTEEELNELKDFIQQH-KGG 983

  Fly   981 AGTAARQQALEAVKANIKWLAANKAQVGEWLANYVQ 1016
            :..|:..:|.|.|.||::|....:.::.:||...|:
Frog   984 SAVASLSRATETVDANVRWQHLYRDELFQWLRKTVK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	140/398 (35%)
		M1_APN_2	151..602	CDD:189008	163/458 (36%)
		ERAP1_C	677..992	CDD:288671	94/322 (29%)
trhde	XP_002939988.3	M1_APN-Q_like	143..588	CDD:341064	159/453 (35%)
trhde	XP_002939988.3	ERAP1_C	673..998	CDD:403137	97/326 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020