DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32473 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_731787.1	Gene:	CG32473 / 41636	FlyBaseID:	FBgn0052473	Length:	1025	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	922	Identity:	327/922 - (35%)
Similarity:	496/922 - (53%)	Gaps:	76/922 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 FRLPKQIKPSKYRLHLRPDLERKN-----YSGNISISLQVLEPIAFIPVHVKQLNVSTVEVKRLD 201
            :|||..:.|..|.:.|.|.|:..:     ::||.|:..:.|.....|.:|..:||: |.|...|.
Zfish    46 YRLPDTLFPHYYNITLWPRLQPDDHGLYVFTGNSSVVFKCLRETDIIIIHCNKLNL-TSEDGYLA 109

  Fly   202 ESGAPLKDITPTL--TFAHPEFEYWVTEFEQPLEAGN-YSLLLNFTGSLVDRITGMYQSSYLDKL 263
            :..|......|::  |:.....:|.|.:....|:||. |.|...|.|.|.|.:.|:|:|.|.:
Zfish   110 KLSAFSTSEVPSVKKTWIEEMTQYLVLQLNGKLKAGELYVLYTEFVGELADDLAGLYRSEYDE-- 172

  Fly   264 KNRSRSIIST-KFEPTYARQAFPCFDEPALKAQFTITVARPSGDEYHVLSN-MPV--ASEYVDGD 324
             :..:.|::| :..||:||:.||||||||:||.|.||:....|..  .||| |.:  ....|||.
Zfish   173 -DGEKKIVATSQMHPTHARKTFPCFDEPAMKAVFHITLIHDRGTV--ALSNGMEIENVDTIVDGQ 234

  Fly   325 -ITEVTFAETVPMSTYLAAFVVSDFQYKETTVEGTSIALKVYAPPAQVE--KTQYALDTAAGVMA 386
             :|..||..|..||:||.|.||||:. ..|:.:||.|  :::|....:|  ...|||:....::.
Zfish   235 PVTVTTFEPTKIMSSYLLALVVSDYT-NVTSADGTLI--RIWARKKAIEDGHGDYALNITGPILK 296

  Fly   387 YYINYFNVSYALPKLDLVAIPDFVSGAMENWGLVTFRETALLYDESTSSSVNKQRVAIVVAHELA 451
            ::.||:||.|.|.|.|.:|:|||..|||||||||.:||:.||||.:.||:.||:|.|.::|||||
Zfish   297 FFENYYNVPYPLSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIAHELA 361

  Fly   452 HQWFGNLVTMNWWNDLWLNEGFASFLEYKGVKQMHPEWDMDNQFVIEELHPVLTIDATLASHPI- 515
            |.|||||||:.|||::||||||||::.|.|.....|.|::.:..:::::|.|..:||..:|||:
Zfish   362 HMWFGNLVTLKWWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASSHPLS 426

  Fly   516 --VKSIESPAEITEYFDTITYSKGAALVRMLENLVGEEKLRNATTRYLVRHIYSTATTE---DYL 575
              .:.|..|.:|.|.|||::|||||:::|||.:.:.|.........||..........|   |:|
Zfish   427 SKEEDIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGEDLWDHL 491

  Fly   576 TAVEEEEG--LEFDVKQIMQTWTEQMGLPVVEVEKSGSTYKLTQKRFLANEDDYAAEAEASSFNY 638
            .....:.|  |...||.||..|..|||.|||.|  :.:|.:::|..||.  |..::....|.|||
Zfish   492 QTAVNKTGTVLPLSVKVIMDRWVLQMGFPVVTV--NTTTGQVSQMHFLL--DPESSLQRTSPFNY 552

  Fly   639 RWSIPITYTSSINSEVQSLIF------NHNDNEATITLPEEASWIKINTNQVGYYRVNYGSEQWA 697
            .|.:||.:..|  ..|||..:      .:||.:.|     .:.|:.:|.|..|||||||....|.
Zfish   553 EWIVPINWMKS--KMVQSRFWLLERTAVYNDMKTT-----GSEWVLLNLNITGYYRVNYDIGNWE 610

  Fly   698 ELISALKNSRETFSTADRAHLLNDANTLAAAGQLNYSVALDLISYLESEQDYVPWSVGTSALATL 762
            .|::.|..:.:..|..:||.:::||..||.|..:..::||...:||..|::|:||.      :.|
Zfish   611 RLLNQLAENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQ------SAL 669

  Fly   763 RNRVYY------TDLYTNYTTYARKLLTPIVEKV-TFT-----VAADHLENRLRIKVLSSACSLG 815
            .|..|:      |::|....:|.:|.:||:.:.. |.|     |.:.|.:...::..:..|||.|
Zfish   670 NNLDYFYLMFTQTEVYRLLQSYTKKQVTPLFDYFKTITEDWSDVPSGHTDQYNQVNAIRFACSTG 734

  Fly   816 HESSLQQAVTLFNQWLASPETRP-NPDIRDVVYYYGLQQVNTEAAWDQVWKLYLDESDAQEKLKL 879
            .:.......:.:.||:..|...| :|::|..||...:.....| .||..|.::  ::.|.|..||
Zfish   735 VDECQNLTSSWYKQWMDQPNHNPIHPNLRSTVYCSAIATGGAE-EWDFGWTMF--KNAAIEADKL 796

  Fly   880 MNCLTAVQVPWLLQRYINWAWDESNVRRQDYFTLLGYISTNPVGQSLVWDYVRENWEKLVDRFGI 944
            |:.|...:...||:||:.:..|.|.:|:||..:::.||::||.||.|.|::||..||.:...:|:
Zfish   797 MSSLACAKNQTLLKRYLGYTLDPSMIRKQDATSVIVYIASNPDGQKLAWEFVRNKWEYMFTEYGV 861

  Fly   945 NERTLGRLIPTITARFSTETKLEEMQQFFAKYPEAGAG--TAARQQALEAVKANIKWLAANKAQV 1007
            .......||..||..||||.:||::.:|.:...|.|.|  |||.:||:|..||||||:|.|:..:
Zfish   862 GSFNFASLISGITKTFSTEAELEQLLKFKSDNSEIGFGSATAALEQAIEKTKANIKWVAENQEDI 926

  Fly  1008 GEWLANYVQQSS 1019
            .:||   |.||:
Zfish   927 TDWL---VAQSA 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32473	NP_731787.1	Peptidase_M1	143..537	CDD:279741	163/411 (40%)
		M1_APN_2	151..602	CDD:189008	181/473 (38%)
		ERAP1_C	677..992	CDD:288671	104/329 (32%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	163/411 (40%)
		M1_APN_2	57..520	CDD:189008	181/471 (38%)
		ERAP1_C	590..911	CDD:288671	104/329 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6076
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920