DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	894	Identity:	290/894 - (32%)
Similarity:	437/894 - (48%)	Gaps:	87/894 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLD-ITSVYVLNREVE--- 127
            |||.::.|.:|.|...|||....|.|:...:.:|.:|||||:::...:| ||:.|....:.|
Human    53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHA 117

  Fly   128 ---KFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKF 189
               .::.|:|:..|....|.:....   ||.|.|.|::.||:.|.|.|.|...:|..|..:.|:|
Human   118 TGFNYQNEDEKVTLSFPSTLQTGTG---TLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQF 179

  Fly   190 EPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD---YTEAIFETSVSMST 251
            |.|.||:||||:||||:||||.|::|.|.... |:|||...:.....|   ..|..|..:..|||
Human   180 EATDARRAFPCWDEPAIKATFDISLVVPKDRV-ALSNMNVIDRKPYPDDENLVEVKFARTPVMST 243

  Fly   252 YLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLT 316
            |||..:|.::....|..| :|:    .::.|....:..:.:||||.......:|..|:.|||||.
Human   244 YLVAFVVGEYDFVETRSK-DGV----CVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLP 303

  Fly   317 KLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWW 381
            |:|:.||.|||:||||:||||||||||||.||..|.::::|.:|..:.||:|||||||||||:||
Human   304 KIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWW 368

  Fly   382 NDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIF 446
            ..||||||||.:::|..|:...|::.:..||...........||..:||||...|..|.|:..||
Human   369 THLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIF 433

  Fly   447 DTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTW 511
            |.|||.||.||||||...:|.:.|::.:..||.|.|..|..|:|....:|. .:...|..:|.||
Human   434 DAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLEN-ASGKPIAAVMNTW 497

  Fly   512 TEQMGYPVLNV--SKVADGS-FKVTQQRFLSNPASY--EEAPSDSAYGYKWSVPITWFADDGSEN 571
            |:|||:|::.|  .:|.|.. .:::|::|.:. .||  |:.|       :|.||||....:....
Human   498 TKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAG-GSYVGEDCP-------QWMVPITISTSEDPNQ 554

  Fly   572 S---FIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALL---IQQLTTSPARFEIAD 630
            :   .:.|....:|.:......||:|||:...|:||..|..::...|   |:.|:..|     .|
Human   555 AKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPP-----VD 614

  Fly   631 RGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYA 695
            |..|.||.|:||.|..:|....|.:......|.::..|...|..|..|...|..::.|.....:.
Human   615 RLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFV 679

  Fly   696 RSLIAGVYEEVGW-TVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDL 759
            :.:.:.:.|.:|| ....:.||...||..:|......|....|::|..||...:|..... |.||
Human   680 KDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQIL-SADL 743

  Fly   760 REIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVR 824
            |..||...::.... ::.|.:.:|........||.::...|........:...|..|.|:|  ||
Human   744 RSPVYLTVLKHGDG-TTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEE--VR 805

  Fly   825 SQDYFTCVQYIA-ANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLE--- 885
            .||..:.:..:| .:..|....|:|.::.|.:|..|:     ..|.||:::       :|::
Human   806 PQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRY-----QGGFLISRL-------IKVQWLT 858

  Fly   886 ---------EVQHFFSKYPESGAGANS-----RLEAVETIKYNIEWLSR 920
                     ||    .:.||.|:...|     :|..::.||    ||.|
Human   859 PVIPALWDAEV----GRSPEVGSSRLSWPTCYQLRDLQLIK----WLER 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	160/396 (40%)
		M1_APN_2	75..518	CDD:189008	182/452 (40%)
		ERAP1_C	593..910	CDD:288671	80/338 (24%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820