Protein Alignment CG8774 and AAP1

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 879
• Identity: 272/879 - (30%)
• Similarity: 437/879 - (49%)
• Gaps: 52/879 - (5%)

  Fly    68 LPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYL-LDITSVYV--LNR-EVEK 128
            ||.|:.|.||::...|:.....|.|..:|.:::.:.:...:..:|| :|..|..:  :|. ||.|
Yeast     6 LPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNK 70

  Fly   129 FELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNE-AGATRTISTTKFEPT 192
            .|.:::...:....|.| .:..|..|.|||.|.:.|::.|.|.:.|.:: .|.|:.::||:.|.|
Yeast    71 NENQQKATLVFPNGTFE-NLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGETKYMATTQMEAT 134

  Fly   193 YARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVSMSTYLVCII 257
            .||:||||||||.:|||||:|:|..|...| :|||...............|.|:..||||||..|
Yeast   135 DARRAFPCFDEPNLKATFAVTLVSESFLTH-LSNMDVRNETIKEGKKYTTFNTTPKMSTYLVAFI 198

  Fly   258 VSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAA 322
            |:|.    ..|::|..  ...::.|:|.......:||.........::...:.:.|||.|:||.|
Yeast   199 VADL----RYVESNNF--RIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLPKMDMVA 257

  Fly   323 IPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLN 387
            :.:|::||||:|||||||...||.|...||....|.:|..:.||:|||||||||||.||..||||
Yeast   258 VHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLN 322

  Fly   388 EGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYE 452
            ||||.:|.:...|...|:|.:.||:....||..|..|:..|||||...|.:.|||..|||.|||.
Yeast   323 EGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIFDAISYS 387

  Fly   453 KGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGY 517
            ||.|::||:...:|.|.|.:.|:.||.|.::.|..|.| |.:..|..:..|:..:|..||:::|:
Yeast   388 KGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGD-LWDALADASGKDVCSVMNIWTKRVGF 451

  Fly   518 PVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADD--GSENSFIYDYDVD 580
            |||:| |.......:||.|:||. ...:|....:.|      ||.....|  |.:|:.:  .:..
Yeast   452 PVLSV-KEHKNKITLTQHRYLST-GDVKEEEDTTIY------PILLALKDSTGIDNTLV--LNEK 506

  Fly   581 SVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADAN 645
            |....:.:| ::.|:|.:|:|.:..:|.:..||.|.:|...    ..:.||..|:.||.||:.:.
Yeast   507 SATFELKNE-EFFKINGDQSGIFITSYSDERWAKLSKQANL----LSVEDRVGLVADAKALSASG 566

  Fly   646 QLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFS-EGYVSYL-TYARSLIAGVYEEVGW 708
            ..|....|::.:....|..||.|....|.|.:|..:.:|. |..::.| .:...|:.....|:||
Yeast   567 YTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGW 631

  Fly   709 TVDADNHLK-NRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQST 772
            .:..|:... .||:|::.:|||..|.......|.|.|..: .|...:..|.|.:.|.:..:.:..
Yeast   632 NIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEY-ANGNKQAIPALFKAVVFNTVARLG 695

  Fly   773 SQSSWDQLFQLFVAETDASEKLKLMYGLSGV-------RNSQYLFDFLAQASSDESIVRSQDYFT 830
            .:::::::|.::.....:.||:..:..|...       |...||.|         ..|.:||::.
Yeast   696 GENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLD---------GTVLNQDFYI 751

  Fly   831 CVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYP 895
            .:|.|..:..|...:|.:.:|.|.::..|....:...|.::.....||.|...||::..|:|:..
Yeast   752 PMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKV 816

  Fly   896 ESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            ..|.. .:..:|::||:...:|:||:...:..:|
Yeast   817 TKGFD-QTLAQALDTIRSKAQWVSRDREIVATYL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	166/442 (38%)
		ERAP1_C	592..912	CDD:463368	76/329 (23%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	166/442 (38%)
		ERAP1_C	517..833	CDD:463368	77/330 (23%)