DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8774 and LAP2

DIOPT Version :10

Sequence 1:NP_650274.2 Gene:CG8774 / 41635 FlyBaseID:FBgn0038136 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_014353.1 Gene:LAP2 / 855682 SGDID:S000004990 Length:671 Species:Saccharomyces cerevisiae


Alignment Length:505 Identity:119/505 - (23%)
Similarity:212/505 - (41%) Gaps:102/505 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 HPDLE----------TGNFTGQQRISIKVVEATN---QIILHSYLLDITSVYVLNREVEKFELEE 133
            |.||.          :|:.|.|.:   |:.|..|   ::.|.:..||:..|::...:.: |::|:
Yeast    71 HTDLNLSVSFEKSAISGSVTFQLK---KLHEGKNKSDELHLDTSYLDVQEVHIDGSKAD-FQIEQ 131

  Fly   134 ERQFLIITLT-EELAVDASITLGIIFGGQMKDKLVGLYSSTYLN----EAGATRTISTTKFEPTY 193
            .::.|...|. ...:.:.:.||.|.|  :..||...|   .:||    :.|.....|  :.|..:
Yeast   132 RKEPLGSRLVINNASCNDNFTLNIQF--RTTDKCTAL---QWLNSKQTKGGKPYVFS--QLEAIH 189

  Fly   194 ARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVSMSTYLVCIIV 258
            ||..|||||.|::|:||..::..|.....:...::.|..    |.....||..|.:..||:.|..
Yeast   190 ARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSK----DTNIYRFEQKVPIPAYLIGIAS 250

  Fly   259 SDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAI 323
            .|.:|.....::....|.|.::......: |.||   :|.|...:...:|....|.:    :..:
Yeast   251 GDLSSAPIGPRSTVYTEPFRLKDCQWEFE-NDVE---KFIQTAEKIIFEYEWGTYDI----LVNV 307

  Fly   324 PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNE 388
            ..:..|.||...:.....|.:.:|         :|....:|||:||.|.|||||...||..||||
Yeast   308 DSYPYGGMESPNMTFATPTLIAHD---------RSNIDVIAHELAHSWSGNLVTNCSWNHFWLNE 363

  Fly   389 GFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVES---PDEITAI----- 445
            |:..|::.:.:.|:|.             :|...:.|.:....:...::|   |:..:.:     
Yeast   364 GWTVYLERRIIGAIHG-------------EPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLN 415

  Fly   446 --------FDTISYEKGGSVIRMLETLVGAE-KFEEAVTNYLVK--------HQFNNTVTDDFLT 493
                    |.|:.||||.:::..|||::|.: :|:..:.:|..|        .||.:|:. :|..
Yeast   416 DNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLY-EFYP 479

  Fly   494 EVEAVVTDLDIKKLMLTWTEQMGYP---------VLNVSKVADGSFKVTQ 534
            |.:.::..:|.:    ||..:.|.|         ..||.::||...::.|
Yeast   480 EKKEILDSVDWE----TWLYKPGMPPRPHFITALADNVYQLADKWVEMAQ 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8774NP_650274.2 M1_APN-Q_like 75..513 CDD:341064 112/473 (24%)
ERAP1_C 592..912 CDD:463368
LAP2NP_014353.1 leuko_A4_hydro 57..669 CDD:274120 119/505 (24%)
Blue background indicates that the domain is not in the aligned region.

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