DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and TMA108

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	949	Identity:	205/949 - (21%)
Similarity:	354/949 - (37%)	Gaps:	238/949 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LPTNLVPTHYELYWH--PDLETGNFTGQQRISIK----------VVEATNQIILHSYLLDITSVY 120
            |...:||:||||...  |...:.||.|...|.:|          :.::..|..|||..|.:.|.:
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH 72

  Fly   121 VLNREVEKFEL---EEERQFLIITLTE---ELAVDASITLGIIFGGQMK------DKLVGLYSST 173
            ...... ||:|   ::..:.|.|..:|   :|:.|..:.|.:.:.|:::      ||..|::.:.
Yeast    73 ATIGST-KFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGIFKTN 136

  Fly   174 YLNEAGATRT--ISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLG 236
            :::....|..  :..|..:|..|...|||.|||:.|:||.:.:. ....|.||||...
Yeast   137 FMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIA-TDAQYKAVSNTPV------- 193

  Fly   237 DYTEAI---------FETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVE 292
            :..||:         |..:..|:|.:....:.|.....|.:|..| .....:..|| ...|....
Yeast   194 EMVEALDSSQKHLVKFAKTPLMTTSVFGFSIGDLEFLKTEIKLEG-DRTIPVSIYA-PWDIANAA 256

  Fly   293 FALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTAN-- 355
            |.|:..|........|:|.||||.|||...:|..:..|||::|::|.:...||..|  ::.||
Yeast   257 FTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIPP--NALANET 319

  Fly   356 -KQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-------- 411
             ::.....:.||:.|||.||.::...|..||.||.||.::      |.|    :|||
Yeast   320 VREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWL------ACH----ILEQNGDLSHYW 374

  Fly   412 ----FQIVALQPVLLYDAK----LSSHPIVQKVESPDEITA-IFDTISYEKGGSVIRMLETLVGA 467
                :.:..::|.:..||.    .|...|.|:....|..|: |||..:|.||..::|.|:...|.
Yeast   375 TSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGE 439

  Fly   468 EKFEEAVTNYLVKHQFNNTVT--------DDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVS- 523
            ...::.:.:.     |.:|.|        .|....:...:...:|...:.:||...|.||:.|.
Yeast   440 SHLQKGLESV-----FEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSSWTRTPGLPVVKVEV 499

  Fly   524 KVADG--SFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDG---------SENSFIYDY 577
            :..||  ..|:||.||: |..|.||  .|......:.||:.....||         ::.:..:||
Yeast   500 EEKDGKTQTKLTQHRFI-NQLSTEE--KDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFDY 561

  Fly   578 DVDSVGIAVPSEVQWIKLNVNQTGYYRVNYE-ESLWALLIQQLTTSPARFEIADRGHLLNDAFAL 641
            .:             :.:|....|||||:|| |..:||:..::|               .:..:.
Yeast   562 PI-------------LVINHLAQGYYRVSYESEECYALINDKIT---------------EETLSE 598

  Fly   642 ADANQLSYKIPLDMTAYLAQE---------------------------RDFVPWYVASNKLRSLH 679
            .|..    ||.||::.::..|                           :.:.|.......|:::.
Yeast   599 IDLR----KIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTID 659

  Fly   680 RSLMFSEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACAL--GVPDCLQQASE 742
            |:.:.|....|:|  .:.::..::.::.|.....:...|...:.:::....|  ....|.:....
Yeast   660 RASLTSSKLQSFL--KKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQI 722

  Fly   743 RFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQ 807
            .|...|:.|.:....:|...:.....|...:...|.::|.|....:           .:|:.|
Yeast   723 YFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSS-----------CTGITN-- 774

  Fly   808 YLFDFLAQASS------------------DESIVRSQDYFTCVQYIAAN---------------- 838
            ::.:...|.||                  |..||:.     .:.:|.:|
Yeast   775 HVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKK-----TLNFITSNIESEGMELALFGFNYN 834

  Fly   839 -------------PVGEPVVWEFYR---EQWPQLTTRFG 861
                         .|....:||:|.   :||.:..||.|
Yeast   835 FKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKG 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	116/440 (26%)
		M1_APN_2	75..518	CDD:189008	126/505 (25%)
		ERAP1_C	593..910	CDD:288671	55/349 (16%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	205/949 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910