DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and APE2

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_012765.3	Gene:	APE2 / 853699	SGDID:	S000001640	Length:	952	Species:	Saccharomyces cerevisiae

Alignment Length:	880	Identity:	267/880 - (30%)
Similarity:	448/880 - (50%)	Gaps:	53/880 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVE-ATNQIILHSYLLDITSVYVLNREVEKFEL 131
            ||.|:||.||:|...||.:|..|.|..:|.:|:.. |.:.:.|::...||.|..:.:....:...
Yeast   102 LPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIIS 166

  Fly   132 EEERQFLIITLTEEL--AVDASITLGIIFGGQMKDKLVGLYSSTYLNE-AGATRTISTTKFEPTY 193
            |||:|.......:..  :...:..|.|.|.|.:.|.:.|.|.:.|.:: .|.|:.::||:.|||.
Yeast   167 EEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTD 231

  Fly   194 ARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTE-AIFETSVSMSTYLVCII 257
            ||:||||||||.:||:||||:|......| :||| ..::.|:.|..: .:|.|:..||||||..|
Yeast   232 ARRAFPCFDEPNLKASFAITLVSDPSLTH-LSNM-DVKNEYVKDGKKVTLFNTTPKMSTYLVAFI 294

  Fly   258 VSDFA-SQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMA 321
            |::.. .:|...:       ..::.|||.......:||.:.......::.:.:.:.|||.|:|..
Yeast   295 VAELKYVESKNFR-------IPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNV 352

  Fly   322 AIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWL 386
            |:.:|::||||:|||||||...||.|...|:....|.:|..:.||:|||||||||||.||..|||
Yeast   353 AVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWL 417

  Fly   387 NEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISY 451
            |||||.:|.:...|...|:|.:.||:....||..|..|:..|||||...|:..|||..|||.|||
Yeast   418 NEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISY 482

  Fly   452 EKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMG 516
            .||.|::||:...:|.|.|.:.|:.||.|.::.|..|:| |.:..|..:..|::.:|..||:::|
Yeast   483 SKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTED-LWDALADASGKDVRSVMNIWTKKVG 546

  Fly   517 YPVLNVSKVADGSFKVT--QQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDV 579
            :||::||:  ||:.|:|  |.|:||   :.:..|.:....|  .|.:.....:|.::|.:.....
Yeast   547 FPVISVSE--DGNGKITFRQNRYLS---TADVKPDEDKTIY--PVFLALKTKNGVDSSVVLSERS 604

  Fly   580 DSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADA 644
            .::.:..|:   :.|:|..|:|.|..:|.:..||.|.||...    ..:.||..|:.|...|:.:
Yeast   605 KTIELEDPT---FFKVNSEQSGIYITSYTDERWAKLGQQADL----LSVEDRVGLVADVKTLSAS 662

  Fly   645 NQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMF--SEGYVSYLTYARSLIAGVYEEVG 707
            ...|....|::.:....|:.||.|....|.:.|:..:.:|  .|...:...:.:.||:|:...:|
Yeast   663 GYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLG 727

  Fly   708 WTV-DADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQS 771
            |.. .:|:....||:|::..||||....|..:.|.:.|:.:... .....|.|.:.:.:..:.:.
Yeast   728 WEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSG-NKEAIPALIKPIVFNTVARV 791

  Fly   772 TSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQ-------YLFDFLAQASSDESIVRSQDYF 829
            ....::::::::::......|||..:..|...:..:       ||||         ..|.:||.:
Yeast   792 GGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFD---------GTVLNQDIY 847

  Fly   830 TCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKY 894
            ..:|.:.|:..|...:|.:.::.|.:|..|........|.::...|:.|.|..|::|::.||:..
Yeast   848 IPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATK 912

  Fly   895 PESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            ...|.. .|..::::||....:|::|:...:..:|
Yeast   913 STKGFD-QSLAQSLDTITSKAQWVNRDRDVVNKYL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	150/391 (38%)
		M1_APN_2	75..518	CDD:189008	167/448 (37%)
		ERAP1_C	593..910	CDD:288671	72/326 (22%)
APE2	NP_012765.3	PepN	90..941	CDD:223385	266/873 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I1338
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	6	5.910