DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and AOPEP

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001372995.1	Gene:	AOPEP / 84909	HGNCID:	1361	Length:	859	Species:	Homo sapiens

Alignment Length:	681	Identity:	141/681 - (20%)
Similarity:	231/681 - (33%)	Gaps:	231/681 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFE---------------LE 132
            |.||  .||....:::...|..|||:.....|.      .||..|:.:               .:
Human   165 PGLE--KFTRSPELTVVSEEFRNQIVRELVTLP------ANRWREQLDYYARCSQAPGCGELLFD 221

  Fly   133 EERQFLIITLT-EELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQ 196
            .:...|.|..| .:.|.|....:.|.:    |.|..| .|.|:.::......:.|.. .|...|.
Human   222 TDTWSLQIRKTGAQTATDFPHAIRIWY----KTKPEG-RSVTWTSDQSGRPCVYTVG-SPINNRA 280

  Fly   197 AFPCFDEPAMKATFAIT-------VVHPSG--------------SYHAVSNMQQTESNY---LGD 237
            .|||.:.|...:|:..|       ||..||              |::....|....|.:   :|.
Human   281 LFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGC 345

  Fly   238 YTEAIFETSVSMSTYLVCIIVSDFASQS--TTVKAN--GIGEDFSMQ-------AYATSHQI--N 289
            :||...||..|          :|.|::.  :..:||  .:|....|:       |.||:.:|  :
Human   346 WTEMKMETWSS----------NDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPH 400

  Fly   290 KVEFALEFGQAVTEYYIQYYKVP------------YPLTKLDMAAIP-DFASGAMEHWGLVTYRE 341
            :|...:....|..|..::.  :|            :|.::||:..:| :|.|..|....::...:
Human   401 RVFAPVCLTGACQETLLRL--IPPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQ 463

  Fly   342 TALLYDPSYSSTANKQSIAGT-LAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPD 405
            :.|         .....:.|| |.|||||.|||..:..:.|.:.||:||||.:::         |
Human   464 SIL---------TGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLE---------D 510

  Fly   406 --WGMLEQFQIVALQPVLLYDAK--------LSSHPIVQKVE-SPDEITA--------------- 444
              |...:|     |.|   |:|:        |....:..::: ||:|:..
Human   511 VFWATAQQ-----LAP---YEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSG 567

  Fly   445 ------------IFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNN--TVTDDFLTEV 495
                        ||..:.|.||..::|.|...:|.|.:...:..::  |.|:.  .::.|||..:
Human   568 ASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFV--HTFHGQLILSQDFLQML 630

  Fly   496 -----EAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGY 555
                 |....:|.::.:...|.|..|.|                     .|...|...
Human   631 LENIPEEKRLELSVENIYQDWLESSGIP---------------------KPLQRERRA------- 667

  Fly   556 KWSVPITWFADDGSENSFIYDYDVDSVGIA--VPSEV-QWIKLNVNQTGYYRVNYEESLWAL--- 614
                        |:|           .|:|  |.:|| :||.:|.......|...||....|
Human   668 ------------GAE-----------CGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPD 709

  Fly   615 --------LIQQLTTSPARFEIADRGHLLND 637
                    |::|.|.||...:...|.:.|.|
Human   710 QLVLLLEHLLEQKTLSPRTLQSLQRTYHLQD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	100/475 (21%)
		M1_APN_2	75..518	CDD:189008	116/546 (21%)
		ERAP1_C	593..910	CDD:288671	14/56 (25%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	95/453 (21%)
		Nucleolar localization signal. /evidence=ECO:0000250\|UniProtKB:Q8BXQ6	689..699		1/9 (11%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810