DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and APM1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	907	Identity:	313/907 - (34%)
Similarity:	490/907 - (54%)	Gaps:	76/907 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYV--------LN 123
            |||...||..|:|..:|||....|||...|.:.:|..|..|:|::..|.:....|        ..
plant     9 RLPKFAVPKRYDLRLNPDLIACTFTGTVAIDLDIVADTRFIVLNAADLSVNDASVSFTPPSSSKA 73

  Fly   124 REVEKFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188
            ....|..|.||.:.|::...|.|.....: |.:.|.|.:.||:.|.|.||| ...|..:.::.|:
plant    74 LAAPKVVLFEEDEILVLEFGEILPHGVGV-LKLGFNGVLNDKMKGFYRSTY-EHNGEKKNMAVTQ 136

  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVSMSTYL 253
            |||..||:.|||:||||.||||.||:..|: ...|:|||...|....|:.....::.|..|||||
plant   137 FEPADARRCFPCWDEPACKATFKITLEVPT-DLVALSNMPIMEEKVNGNLKIVSYQESPIMSTYL 200

  Fly   254 VCIIVS--DFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLT 316
            |.|:|.  |:....|   ::||    .::.|....:.::.:|||..|....:.:.:|:.|||||.
plant   201 VAIVVGLFDYVEDHT---SDGI----KVRVYCQVGKADQGKFALHVGAKTLDLFKEYFAVPYPLP 258

  Fly   317 KLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWW 381
            |:||.||||||:||||::|||||||||||||..:|:.:|||.:|..:|||:|||||||||||:||
plant   259 KMDMIAIPDFAAGAMENYGLVTYRETALLYDEQHSAASNKQRVATVVAHELAHQWFGNLVTMEWW 323

  Fly   382 NDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIF 446
            ..||||||||.::.|...:::.|:|.:..||...:.:.:.| |....||||..:|....||..||
plant   324 THLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGLRL-DGLEESHPIEVEVNHAAEIDEIF 387

  Fly   447 DTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTW 511
            |.|||.||.||||||::.:|||.|::::..|:..|.::|..|:|....:||...: .:.|||.:|
plant   388 DAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTEDLWAALEAGSGE-PVNKLMSSW 451

  Fly   512 TEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGS---ENSF 573
            |:|.||||:: :|:.||..::.|.||||:     .:|.:.    :|.||:|...  ||   ..:|
plant   452 TKQKGYPVVS-AKIKDGKLELEQSRFLSS-----GSPGEG----QWIVPVTLCC--GSYEKRKNF 504

  Fly   574 IYD-----YDVDSV---GIAVPSE-----VQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPAR 625
            :.:     ||:..:   .||..|:     ..|||:||:|.|:|||.|::|| |..::..|.|.:.
plant   505 LLESKSGAYDLKELLGCSIADGSDKINGTCSWIKINVDQAGFYRVKYDDSL-AAGLRNATESQSL 568

  Fly   626 FEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMF-SEGYV 689
            ..| ||..:|:|:|||..|.|.|....|.:.:...:|.|:.   |.||.:...::.:.. ::...
plant   569 TSI-DRYGILDDSFALTMARQQSLASLLTLCSAYKKELDYT---VLSNLIAISYKVVKIGADANQ 629

  Fly   690 SYLTYARSLIAGVYE----EVGW-TVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLE 749
            ..::..:....||::    ::|| ....::||...||..:|||....|..:.|::|..||..||.
plant   630 ELMSGIKHFFIGVFQFAAGKLGWDPKQGESHLDAMLRGEVLTALAVFGHDETLKEAVRRFDAFLA 694

  Fly   750 NPTTRP--SPDLREIVYYYGMQQS--TSQSSWDQLFQLFVAETDAS-EKLKLMYGLSGVRNSQYL 809
            :..| |  .||:|...|...||::  :.:|.::.|.::: .|||.| ||.:::..|:...:...:
plant   695 DRNT-PLLPPDIRRAAYVAVMQRANKSDKSGYESLLRVY-RETDLSQEKTRILGSLASCPDPTIV 757

  Fly   810 FDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQI 874
            .|.|....|||  ||:||....:..::..  |..|.|::.:|:|..:...:| :.....|.|:.:
plant   758 QDVLNFVLSDE--VRNQDALYGLSGVSWE--GREVAWKWLQEKWEYIGNTWG-SGFLITRFISAV 817

  Fly   875 TANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLS--RNEADITDWLSGTAS 934
            .:.|||..|.:||:.||:...:... |.:..:::|.:..|..|:.  :.|.::|..::..:|
plant   818 VSPFASFEKAKEVEEFFATRSKPSM-ARTLKQSIERVHINANWVESIKKEDNLTQLVAQLSS 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	163/396 (41%)
		M1_APN_2	75..518	CDD:189008	184/452 (41%)
		ERAP1_C	593..910	CDD:288671	93/327 (28%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	181/446 (41%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	95/331 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920