Protein Alignment CG8774 and Anpep

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_112274.1
• Gene: Anpep / 81641
• RGDID: 2991
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 1001
• Identity: 302/1001 - (30%)
• Similarity: 504/1001 - (50%)
• Gaps: 117/1001 - (11%)

  Fly     5 GYWLQVVLSWAVVAFATATV--VVAVQKAQLERDLRDVQDK--------------------IDVF 47
            |:::...|....:....|.|  ::|:.....:...|:.::.                    ||..
  Rat     4 GFYISKTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSAIAPTLPGSTSATTSTTNPAIDES 68

  Fly    48 EEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGN------FTGQQRISIKVVEATNQ 106
            :.|:             .||||..|:|..|::...|.| |.|      |.|...:.....|.||.
  Rat    69 KPWN-------------QYRLPKTLIPDSYQVTLRPYL-TPNEQGLYIFKGSSTVRFTCNETTNV 119

  Fly   107 IILHSYLLDITSVYVLNR----------------EVEKFELEEERQFLIITLTEELAVDASITLG 155
            ||:||..|:.|     |:                .::..||.|..::|::.|...|.......:.
  Rat   120 IIIHSKKLNYT-----NKGNHRVALRALGDTPAPNIDTTELVERTEYLVVHLQGSLVKGHQYEMD 179

  Fly   156 IIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGS 220
            ..|.|::.|.|.|.|.|.|: |.|..:.::||:.:...||::|||||||||||:|.||::||: :
  Rat   180 SEFQGELADDLAGFYRSEYM-EGGNKKVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPN-N 242

  Fly   221 YHAVSNMQQTESNYLGD-----YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQ 280
            ..|:|||...:|..|.:     .||  |..:..|||||:..|||:| .....|..|.:    .::
  Rat   243 LTALSNMLPKDSRTLQEDPSWNVTE--FHPTPKMSTYLLAYIVSEF-KYVEAVSPNRV----QIR 300

  Fly   281 AYATSHQINK--VEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETA 343
            .:|....|::  .::||:....:..::.|:|...|||.|.|..|:|||.:||||:||||||||:|
  Rat   301 IWARPSAIDEGHGDYALQVTGPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESA 365

  Fly   344 LLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGM 408
            |::||..||.:||:.:...:|||:||||||||||:.||||||||||||.|:::.|.:...|.|.:
  Rat   366 LVFDPQSSSISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNL 430

  Fly   409 LEQFQIVALQPVLLYDAKLSSHPI---VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKF 470
            .:...:..:..|:..||..||||:   ..:|.:|.:|:.:||:|:|.||.||:|||.:.:..:.|
  Rat   431 KDLIVLNDVYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLF 495

  Fly   471 EEAVTNYLVKHQFNNTVTDDFLTEVE-------AVVTDLDIKKLMLTWTEQMGYPVLNVSKVADG 528
            ::.:::||...|::||:..|....::       |:.....:..:|..|..|||:||:.|:   ..
  Rat   496 KKGLSSYLHTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVN---TS 557

  Fly   529 SFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQWI 593
            :.::.|:.||.:|.|....|||  :.|.|.|||. :..:|.|:.:..:.:.:.......|..:|:
  Rat   558 TGEIYQEHFLLDPTSKPTRPSD--FNYLWIVPIP-YLKNGKEDHYWLETEKNQSAEFQTSSNEWL 619

  Fly   594 KLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAY 658
            .||:|.||||:|||:|:.|..:..||.|..:...:.:|..:::|:|.||.|.:||..:||..|.:
  Rat   620 LLNINVTGYYQVNYDENNWRKIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLF 684

  Fly   659 LAQERDFVPWYVASNKLRSLHRSLMF--SEGYVSYLTYARSLIAGVY-----EEVGWTVDADNHL 716
            ||.|.:::||..|.:.|.  :..|||  ||.|.....|.:..:..::     :...|.......:
  Rat   685 LASETEYMPWEAALSSLN--YFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNNWLDRPPTLM 747

  Fly   717 KNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRP-SPDLREIVY----YYGMQQSTSQSS 776
            :....::.::.||:.|:.:|.......:|.::.|....| .|:||..||    .:|     .:..
  Rat   748 EQYNEINAISTACSSGLEECRDLVVGLYSQWMNNSDNNPIHPNLRSTVYCNAIAFG-----GEEE 807

  Fly   777 WDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVG 841
            |:..::.|...|..:|..||...|: ..|..::.:.....:.:...:|.||..:.:..||.|.||
  Rat   808 WNFAWEQFRKATLVNEADKLRSALA-CSNEVWILNRYLSYTLNPDYIRKQDATSTIVSIANNVVG 871

  Fly   842 EPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRL- 905
            :.:||:|.|..|.:|...:|..:.:|..||..:|..|:|..:|::::.|......:|.|:.:|.
  Rat   872 QTLVWDFVRSNWKKLFEDYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKEDNSATGFGSGTRAL 936

  Fly   906 -EAVETIKYNIEWLSRNEADITDWLS 930
             :|:|..|.||:|:..|:..:..|.:
  Rat   937 EQALEKTKANIKWVKENKDVVLKWFT 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	168/476 (35%)
		ERAP1_C	592..912	CDD:463368	91/333 (27%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		3/34 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..68		2/23 (9%)
		Metalloprotease	69..965		294/936 (31%)
		M1_APN-Q_like	84..545	CDD:341064	168/475 (35%)
		ERAP1_C	618..945	CDD:463368	91/334 (27%)