Protein Alignment CG8774 and Erap1

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_109636.1
• Gene: Erap1 / 80898
• MGIID: 1933403
• Length: 930
• Species: Mus musculus
• Alignment Length: 904
• Identity: 305/904 - (33%)
• Similarity: 473/904 - (52%)
• Gaps: 64/904 - (7%)

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFEL 131
            |||..:.|.||:|..|.:|.|..|.|:..:.|.....|:.||:||:.|.|:.. .|.|...:...
Mouse    42 RLPEYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQISKA-TLRRGAGEMLS 105

  Fly   132 EEERQFLIITLTEELAVDAS--------ITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188
            ||..:.|.....|::|:.|:        .|:.|.:...:.:...|.|.|||..:.|..|.::.|:
Mouse   106 EEPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQEGEMRILAATQ 170

  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTES-NYLGDYTEAIFETSVSMSTY 252
            ||||.||.|||||||||:||:|:|.:.. ...:.|:|||...:| |......|..|:.:|.||||
Mouse   171 FEPTAARMAFPCFDEPALKASFSIKIKR-DPRHLAISNMPLVKSVNVAEGLIEDHFDITVKMSTY 234

  Fly   253 LVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTK 317
            ||..|:|||.|.|...| :|:    .:..||...:||:.::||:....:.|:|..|:.:||||.|
Mouse   235 LVAFIISDFKSVSKMTK-SGV----KVSVYAVPDKINQADYALDAAVTLLEFYEDYFNIPYPLPK 294

  Fly   318 LDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWN 382
            .|:||||||.|||||:|||.||||::||||...||.::|..|...::||:|||||||||||:|||
Mouse   295 QDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWFGNLVTMEWWN 359

  Fly   383 DLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFD 447
            |||||||||::|::..|...||:. .:|.:........:..||..||||:...||:|.:|..:||
Mouse   360 DLWLNEGFAKFMEFVSVTVTHPEL-KVEDYFFGKCFNAMEVDALNSSHPVSTPVENPAQIREMFD 423

  Fly   448 TISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVV-TD---------- 501
            .:|||||..::.||...:.|:.|:..:..||.|:.:.||..:|....:..:. ||
Mouse   424 DVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCS 488

  Fly   502 ---------------LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSDS 551
                           :|:|.:|.|||.|.|:|::.:: |:..:..:.|:.::.....:.|.
Mouse   489 RSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITIT-VSGRNVHMKQEHYMKGSERFPET---- 548

  Fly   552 AYGYKWSVPITWF-ADDGSENSFIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALL 615
              ||.|.||:|:. :...|...|:.....|.  :.:|..|||||.||...|||.|:|.:..||.|
Mouse   549 --GYLWHVPLTFITSKSDSVQRFLLKTKTDV--LILPEAVQWIKFNVGMNGYYIVHYADDGWASL 609

  Fly   616 IQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHR 680
            ...|..:.......||..|:|:||.|....:||.:..||:|.||..|.:.:|.:.|.|:|..:::
Mouse   610 SGLLKEAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQALNELIPMYK 674

  Fly   681 SLMFSEGYVSYLT----YARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAACALGVPDCLQQAS 741
             ||.....:...|    :...|:..:.::..|| |..:..:..||..:|..||......|:|:|.
Mouse   675 -LMEKRDMIEVETQFKDFLLKLLKDLIDKQTWT-DEGSVSERMLRSQLLLLACVRNYQPCVQRAE 737

  Fly   742 ERFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRN 805
            ..|..:..:......| |:...|:..|.|.:   ..||.|:..:.:...::||.::.:.|...::
Mouse   738 RYFREWKSSNGNMSIPIDVTLAVFAVGAQNT---EGWDFLYSKYQSSLSSTEKSQIEFSLCTSKD 799

  Fly   806 SQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRL 870
            .:.|...|.|:...| |:::|::...:..|..||||.|:.|:|.||.|.:|..:|.|.:.:...:
Mouse   800 PEKLQWLLDQSFKGE-IIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHM 863

  Fly   871 IAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            :...|..|::..:||||:.|||...|:|:......:.:|||:.||.|:.:|...|..||
Mouse   864 VMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTIETIEENIRWMDKNFDKIRLWL 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	181/472 (38%)
		ERAP1_C	592..912	CDD:463368	93/324 (29%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	181/472 (38%)
		ERAP1_C	586..905	CDD:463368	93/324 (29%)