DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and Erap1

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	305/930 - (32%)
Similarity:	477/930 - (51%)	Gaps:	92/930 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVYVLNREVEKFEL 131
            |||..:.|.||:|..|.:|.|..|.|:..:.|.|.:.|:.||:||:.|.|:.. .|.|..|:...
  Rat    42 RLPEYITPIHYDLMIHANLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQISKA-TLRRGAEEMLP 105

  Fly   132 EEERQFLIITLTEELAV--------DASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188
            ||..:.:..:..|::|:        .:..|:.|.:...:.:...|.|.|||..:.|..|.::.|:
  Rat   106 EEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEGERRILAATQ 170

  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD-YTEAIFETSVSMSTY 252
            ||||.||.|||||||||:||:|:|.:.. ...:.|:|||...:|..:.: ..|..|:.:|.||||
  Rat   171 FEPTAARMAFPCFDEPALKASFSIKIKR-DPRHLAISNMPLVKSVTVAEGLIEDHFDITVKMSTY 234

  Fly   253 LVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTK 317
            ||..|:|||.|.|...| :|:    .:..||...:||:.::||:....:.|:|..|:.:||||.|
  Rat   235 LVAFIISDFKSVSKMTK-SGV----KVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPK 294

  Fly   318 LDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWN 382
            .|:||||||.|||||:|||.||||:|||||...||.::|..|..|::||:|||||||||||:|||
  Rat   295 QDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGNLVTMEWWN 359

  Fly   383 DLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVAL----QP----------------------VL 421
            |||||||||::|::..|...||:   |:..||:..    :|                      .:
  Rat   360 DLWLNEGFAKFMEFVSVTVTHPE---LKVMQILTANHQNEPEDLSGRAMERTEEEYFFGKCFNAM 421

  Fly   422 LYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNT 486
            ..||..||||:...||:|.:|..:||.:|||||..::.||...:.|:.|:..:..||.|:.:.||
  Rat   422 EVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNT 486

  Fly   487 VTDDFLTEVEAVV-TD-------------------------LDIKKLMLTWTEQMGYPVLNVSKV 525
            ..:|....:..:. ||                         :|||.:|.|||.|.|:|::.:: |
  Rat   487 KNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQKGFPLITIT-V 550

  Fly   526 ADGSFKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWF-ADDGSENSFIYDYDVDSVGIAVPSE 589
            ...:..:.|:.::.....:.|.      |..|.||:|:. :...|...|:.....|.  |.:|..
  Rat   551 RGRNVHLKQEHYMKGSECFPET------GSLWHVPLTFITSKSDSVQRFLLKTKTDV--IILPEA 607

  Fly   590 VQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLD 654
            |:|||.||...|||.|:|.:..||.|...|..:.......||..|:|:||.|....:||.:..||
  Rat   608 VEWIKFNVGMNGYYIVHYGDDGWASLNGLLKEAHTTISSNDRASLINNAFQLVSIGKLSIEKALD 672

  Fly   655 MTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLT----YARSLIAGVYEEVGWTVDADNH 715
            :..||..|.:.:|.:...|:|..::: ||.....|...|    :...|:..:..:..|| |..:.
  Rat   673 LILYLKNETEIMPIFQGLNELIPMYK-LMEKRDMVEVETQFKDFLLRLLKDLINKQTWT-DEGSV 735

  Fly   716 LKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSP-DLREIVYYYGMQQSTSQSSWDQ 779
            .:..||..:|..||......|:|:|...|..:..:......| |:...|:..|.|.:   ..||.
  Rat   736 SERMLRSQLLLLACVHRYQLCVQRAERYFREWKASNGNMSLPIDVTLAVFAVGAQNT---EGWDF 797

  Fly   780 LFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPV 844
            |:..:.:...::||.::.:.|...::.:.|...|.|:...| |:::|::...:..|..||||.|:
  Rat   798 LYSKYQSSLSSTEKSQIEFSLCISQDPEKLQWLLDQSFKGE-IIKTQEFPHILTLIGRNPVGYPL 861

  Fly   845 VWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVE 909
            .|:|.:|.|.::..:|.|.:.:...::...|..|::..:||||:.|||...::|:......:.:|
  Rat   862 AWKFLKENWNKIVQKFELGSSSIAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTIE 926

  Fly   910 TIKYNIEWLSRNEADITDWL 929
            ||:.||.|:.:|...|..||
  Rat   927 TIEENIRWMDKNFDKIRLWL 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	170/421 (40%)
		M1_APN_2	75..518	CDD:189008	189/503 (38%)
		ERAP1_C	593..910	CDD:288671	86/321 (27%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	170/421 (40%)
		M1_APN_2	50..544	CDD:189008	189/503 (38%)
		ERAP1_C	611..927	CDD:288671	86/321 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820