DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8774 and npepps

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	884	Identity:	287/884 - (32%)
Similarity:	438/884 - (49%)	Gaps:	48/884 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLD-ITSVYVLNREVE--- 127
            ||||::.|.:|.|...|||....|.|:...:::|..|||||:::...:| ||:.|....:.|
Frog     9 RLPTDVRPVNYGLCLKPDLIDFTFEGKLEATVEVQNATNQIVMNCADIDIITASYAPEGDEEIHA 73

  Fly   128 -KFELEEERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTKFEP 191
             .|..:.|.:.:.::....|...|.: |.|.|.|::.||:.|.|.|.|....|..|..:.|:||.
Frog    74 TGFNYQNEDEKVTLSFPSTLQKGAGM-LKIDFVGELNDKMKGFYRSKYATATGEVRYAAVTQFEA 137

  Fly   192 TYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGD---YTEAIFETSVSMSTYL 253
            |.||:||||:||||:||||.:.::.|.... |:|||...:.....|   ..|..|..:..|||||
Frog   138 TDARRAFPCWDEPAIKATFDVILIVPKDRV-ALSNMNLIDRKPYPDDENLVEVKFARTPIMSTYL 201

  Fly   254 VCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKL 318
            |..:|.::....|. .::|:    .::.|....:..:.:||||.......:|..|:.|||||.|:
Frog   202 VAFVVGEYDFVETR-SSDGV----LVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKI 261

  Fly   319 DMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWND 383
            |:.||.|||:||||:||||||||||||.||..|.::::|.:|..:.||:|||||||||||:||..
Frog   262 DLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTH 326

  Fly   384 LWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDT 448
            ||||||||.:::|..|:...|::.:..||...........||..:||||...|..|.|:..|||.
Frog   327 LWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALENSHPIEVSVGHPSEVDEIFDA 391

  Fly   449 ISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLMLTWTE 513
            |||.||.||||||...:|.|.|.:.:..||.|.|..|..|:|....:|. .:...|..:|.|||:
Frog   392 ISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATEDLWESLEQ-ASGKPIAAVMNTWTK 455

  Fly   514 QMGYPVLNV-SKVADGS--FKVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENS--- 572
            |||:|::.| |:..:.|  .|::|::|.::.|...:   ||   |:|.|||:....:...::
Frog   456 QMGFPLICVESEQKEDSVVLKLSQKKFCASGAPNSD---DS---YQWMVPISICTSESPASATVK 514

  Fly   573 FIYDYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYEESLWALL---IQQLTTSPARFEIADRGHL 634
            .:.|....:|.:......||:|||....|:||..|..::...|   |:.|:..|     .||..|
Frog   515 ILMDKPEMTVVLEGVKPHQWVKLNPGTVGFYRTQYSTTMLESLLPGIRDLSLQP-----VDRLGL 574

  Fly   635 LNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFSEGYVSYLTYARSLI 699
            .||.|:||.|..::....|.:......|.::..|...|..|..|...|..::.:.....:.|.:.
Frog   575 QNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFHEEIQCFVRDVF 639

  Fly   700 AGVYEEVGW-TVDADNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTTRPSPDLREIV 763
            :.:.:.:|| ....:.||...||..:|......|....|::|..||...::..... |.|||..|
Frog   640 SPIGQRLGWDPKPGEGHLDALLRGLVLGKLGKAGHQPTLEEARRRFKEHVDGRNVL-SADLRSPV 703

  Fly   764 YYYGMQQSTSQSSWDQLFQLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDY 828
            |...::.. ..|:.:.:.:|........||.::...|..:.....:...|:.:.|::  ||.||.
Frog   704 YVTVLKHG-DNSTLETMMKLHKQADMQEEKNRIERVLGAIAEQDLIKKVLSFSLSED--VRPQDT 765

  Fly   829 FTCVQYIA-ANPVGEPVVWEFYREQWPQLTTRFGLNNRNF--GRLIAQITANFASSVKLEEVQHF 890
            ...:..:| .:.:|....|.|.::.|.:|..|:   ...|  .|||......|||.....|::.|
Frog   766 VCVIGGVAGGSKLGRKCAWNFVKDNWEELYNRY---QGGFLISRLIKLSLDGFASDKMAAEIKAF 827

  Fly   891 FSKYPESGAGANSRLEAVETIKYNIEWLSRNEADITDWL 929
            |..:|...|....: :..|.|..|..||.|:...|..:|
Frog   828 FDAHPAPSAERTVQ-QCCENILLNAGWLKRDAEAIHHYL 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	157/394 (40%)
		M1_APN_2	75..518	CDD:189008	179/450 (40%)
		ERAP1_C	593..910	CDD:288671	76/323 (24%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	157/394 (40%)
		M1_APN_2	17..460	CDD:189008	179/450 (40%)
		ERAP1_C	535..846	CDD:288671	76/323 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010