Protein Alignment CG8774 and Lvrn

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_083284.1
• Gene: Lvrn / 74574
• MGIID: 1921824
• Length: 991
• Species: Mus musculus
• Alignment Length: 1026
• Identity: 301/1026 - (29%)
• Similarity: 477/1026 - (46%)
• Gaps: 146/1026 - (14%)

  Fly     2 FLSGYWLQVVLSWAVVAFATATVVVAVQKAQLERDLRDVQDKIDVFEEWSGESRTRMK------- 59
            |.||.::...::..:.|.....::|.|..|.|......||.        |.:..:|:|
Mouse     5 FSSGVYVSRGVALLLAALTAVLLLVLVALASLYGSCAHVQP--------SEQGNSRVKNTSLWPP 61

  Fly    60 -----------REDTT-------------DY-RLPTNLVPTHYEL-YW---HPD-LETGN--FTG 92
                       :|.|.             |: |||..|||.||:| .|   .|| |...|  |||
Mouse    62 GGQEWALPTPAQEPTVGTSQDLGPPSGPWDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTG 126

  Fly    93 QQRISIKVVEATNQIILHSYLLDITSVYV------------LNR-EVEKFELEEERQFLIITLTE 144
            :..|:::...|:::::|||:||:...|.|            :.| :|||.....:.||:::.|.:
Mouse   127 RVNITVRCTVASSRLLLHSFLLNYKQVEVWGPLAQDTRNATVGRVQVEKVWFAPDMQFVVLDLGQ 191

  Fly   145 ELAVDASITLGIIFGGQ-MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKA 208
            .|...:...|...|.|| ::..|.||:.:.|.:| ...|.:..|:.|||:||..||||||||:||
Mouse   192 SLEPGSRYELSFHFSGQVLQVGLEGLFLNLYHDE-DELRALVATQMEPTFARHVFPCFDEPALKA 255

  Fly   209 TFAITVVHPSGSYHAVSNMQQTESNYLGD-----YTEAIFETSVSMSTYLVCIIVSDFASQSTTV 268
            ||.|||:|..| |.|:|||.|...:...|     :|...|.|:..|.||||.::|.|....|.|.
Mouse   256 TFNITVIHHPG-YAALSNMPQLGQSERIDVNGSRWTVTTFHTTPRMPTYLVALVVCDLDHISRTE 319

  Fly   269 KANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEH 333
            :    |::..:.|.........::||......:..:....:.:.|.|.|.|:.|:|.|||||||:
Mouse   320 R----GKEIRVWARKDDIASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMEN 380

  Fly   334 WGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKG 398
            |||:.:.|::||.:|....|..:..|...:|||:.||||||||||.|||::|||||||.|.:.:.
Mouse   381 WGLLIFDESSLLLEPEDELTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELEL 445

  Fly   399 VNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQKVES---PDEITAIFDTISYEKGGSVIRM 460
            .|..:|...|...|....|..:|..|..|.|..:...||:   ..||..:||..:|:||..:..|
Mouse   446 TNYFYPKVPMNMIFFFTVLHGILGEDHALESRAVSTAVENFTETSEINRLFDLYTYKKGACMAWM 510

  Fly   461 LETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVTDLD-------IKKLMLTWTEQMGYP 518
            |.:.:....|..|:.:||....::|...||....::..:.:.:       :|.:|.:||.:.|:|
Mouse   511 LASFLSPHLFINALKSYLETFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKGIMDSWTHRGGFP 575

  Fly   519 VLNVSKVADGSF--------KVTQQRFLSNPASYEEAPSDSAYGYKWSVPITWFADDGSENSFIY 575
            ::.|: |:.|..        ||..|..||:.::             |.|||.|. .:|.....::
Mouse   576 IITVN-VSTGVVKQEPFYLDKVENQTLLSHNST-------------WIVPIFWM-KNGIPQPLVW 625

  Fly   576 DYDVDSVGIAVP------SEVQWIKLNVNQTGYYRVNYEESLWALLIQQLTTSPARFEIADRGHL 634
               :|...:..|      |:..|:.||.|.||||||||:|..|..|.:||...|....:.:|..|
Mouse   626 ---LDKSNMMFPGMKLSDSDSDWVILNFNVTGYYRVNYDELGWKKLSEQLEKDPKAIPVINRLQL 687

  Fly   635 LNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASNKLRSLHRSLMFS-EGYVSYLTYARSL 698
            ::|||||...|.:..:..||:|.|:|:|.:.:.|:..  .|..::|.:::. ..|..|....:.|
Mouse   688 VSDAFALTKNNYIEIETALDLTKYIAEEDEILVWFEV--LLNLINREVIYDVNNYALYPLLKKYL 750

  Fly   699 IAGVYEEVGWTVDA----------DNHLKNRLRVSILTAACALGVPDCLQQASERFSTFLENPTT 753
            :.. :..:..|..|          ||:|.......|...||.||:.||||.:.|.|..:..:|.|
Mouse   751 LKR-FNSIWNTYSAIIRENVASLQDNYLSLFSLERIFETACWLGLEDCLQLSRELFKKWTAHPET 814

  Fly   754 RPSPDLREIVYYYGMQQSTSQSSWDQLFQLFV---AETDASEKLKLMYGLSGVRNSQYLFDFLAQ 815
            ...|.:...|....:... |...||.||.|::   .|.|.|.:.:|::.:|..::...|..|:..
Mouse   815 AIPPQIENAVLCSAVALG-SDKDWDFLFNLYINTTEEEDESRRRRLVHAMSCSKDPWILNRFMEY 878

  Fly   816 ASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFGLNNRNFGRLIAQITANFAS 880
            |.:..|...|:.....|  :|.:.||..:..:|..:.|..:|.|:|::  ....|:..:....::
Mouse   879 AITAVSSNFSETNIIVV--VATSEVGRYIAKDFLMDNWVAVTERYGMD--WLDALVPVLGRTVST 939

  Fly   881 SVKLEEVQHFFSKYPE--SGAGANSRLEAVET--------IKYNIEWLSRN 921
            ..::.|:|||||...|  ......::|:|::|        |...:|||.:|
Mouse   940 DQQVTELQHFFSTVLEEHQRVVVQAKLQAMKTKNLQNKKRIARVVEWLRKN 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	160/473 (34%)
		ERAP1_C	592..912	CDD:463368	94/343 (27%)
Lvrn	NP_083284.1	M1_APN-Q_like	102..570	CDD:341064	160/473 (34%)
		ERAP1_C	645..964	CDD:463368	91/326 (28%)