Protein Alignment CG8774 and ERAP2

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 928
• Identity: 315/928 - (33%)
• Similarity: 492/928 - (53%)
• Gaps: 82/928 - (8%)

  Fly    56 TRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVY 120
            |..:|....:.|||:.::|.||:|:.||:|.:.:|...::|.:.|..||..|||||..|:||:..
Human    57 TNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNAT 121

  Fly   121 VLNREVEKF-----ELE----EERQFLIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTYLN 176
            :.:.|..::     ||:    ...:.:.:.:.|:|.......:.:.|..::.|...|.|.|||..
Human   122 LQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRT 186

  Fly   177 EAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYL-GDYTE 240
            ..|.||.::.|.||||.||.||||||||..||.|:|.:...| .:.|:|||.:.::..| |...|
Human   187 LGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRES-RHIALSNMPKVKTIELEGGLLE 250

  Fly   241 AIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINKVEFALEFGQAVTEYY 305
            ..|||:|.||||||..||.||.|.| ...::|:    .:..||:..:.|:..:||:....:.::|
Human   251 DHFETTVKMSTYLVAYIVCDFHSLS-GFTSSGV----KVSIYASPDKRNQTHYALQASLKLLDFY 310

  Fly   306 IQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQ 370
            .:|:.:.|||:|||:.||||||.||||:|||:|||||:||:||..||.::|..:...:|||:|||
Human   311 EKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQ 375

  Fly   371 WFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPVLLYDAKLSSHPIVQK 435
            ||||||||:||||:||.||||:||:...|||.:|:....:.|..|..: |:..|:..||.||.:.
Human   376 WFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFE-VITKDSLNSSRPISKP 439

  Fly   436 VESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEAVVT 500
            .|:|.:|..:||.:||.||..::.||:..:|.|||::.:..||.|..:.|...||..:.:.....
Human   440 AETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCL 504

  Fly   501 DLD--------------------------IKKLMLTWTEQMGYPVLNVSKVADG-SFKVTQQRFL 538
            :.|                          :|::|.|||.|.|.|:|.|.:  || |.::.|:|||
Human   505 ESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQ--DGCSLRLQQERFL 567

  Fly   539 SNPASYEEAPSDSAY--GYKWSVPITWFADDGSENSFIYDYDVDSV--GIAVPSEVQWIKLNVNQ 599
            .  ..::|.|...|.  .|.|.:|:|:   ..|.::.|:.:.:.|.  .:.:|.:..|:|.||:.
Human   568 Q--GVFQEDPEWRALQERYLWHIPLTY---STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDS 627

  Fly   600 TGYYRVNYEESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERD 664
            .|||.|:||...|..||.||..:.......||..|::|.|.|..|.:|:....||||.||..|..
Human   628 NGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETS 692

  Fly   665 FVPWYVASNKLRSLHRSL------MFSEGYVSY-LTYARSLIAGVYEEVGWTVDADNHLKNRLRV 722
            ........:.|.|.:..:      ..||....| |.|.:.:|    :...|: |..:.....||.
Human   693 SPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVI----DRQSWS-DKGSVWDRMLRS 752

  Fly   723 SILTAACALGVPDCLQQASERFSTFLEN------PTTRPSPDLREIVYYYGMQQSTSQSSWDQLF 781
            ::|..||.|....|:|:|:|.||.::|:      ||     |:.:|||..|.|   :.:.|:.|.
Human   753 ALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPT-----DVLKIVYSVGAQ---TTAGWNYLL 809

  Fly   782 QLFVAETDASEKLKLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVW 846
            :.:.....::|:.|::|.||..::.:.|.. |.:...:..::::|:....:..||..|.|:.:.|
Human   810 EQYELSMSSAEQNKILYALSTSKHQEKLLK-LIELGMEGKVIKTQNLAALLHAIARRPKGQQLAW 873

  Fly   847 EFYREQWPQLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETI 911
            :|.||.|..|..:|.|.:.:...:|:..||:|:|..||:||:.||......|:..:.....:|||
Human   874 DFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETI 938

  Fly   912 KYNIEWLSRNEADITDWL 929
            ..||:||.:|...:..||
Human   939 TKNIKWLEKNLPTLRTWL 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	180/473 (38%)
		ERAP1_C	592..912	CDD:463368	97/332 (29%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	180/473 (38%)
		ERAP1_C	620..938	CDD:463368	96/331 (29%)