DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and Enpep

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	921	Identity:	354/921 - (38%)
Similarity:	526/921 - (57%)	Gaps:	74/921 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DKIDVFEEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQ 106
            |..|...||.             ::|||..:.|.||:|.....:|...:||...||:.:.:.|..
  Rat    72 DSDDESGEWK-------------NFRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRD 123

  Fly   107 IILHSYLLDITSVYVLNREVEK-------FELEEERQFLIITLTEELAV---DASITLGIIFGGQ 161
            :.||.....||.:..|.|...:       ||.::: ::::|...|:||.   |:...|.|.|.|.
  Rat   124 LWLHIRETRITKLPELRRPSGEQVPIRRCFEYKKQ-EYVVIQAEEDLAATSGDSVYRLTIEFEGW 187

  Fly   162 MKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSN 226
            :...|||.|.:|| .|.|.|::|:.|..|||.||::|||||||..|||:.|:::||. .|.|:||
  Rat   188 LNGSLVGFYRTTY-TEDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPK-EYSALSN 250

  Fly   227 MQ-QTESNYLGDYTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQINK 290
            |. :.|.....|:.:..|..||.|||||||..|..|.|...|.::   |:..::  |...:|...
  Rat   251 MPVEKEETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSIQRTSRS---GKPLTV--YVQPNQKQT 310

  Fly   291 VEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTAN 355
            .|:|....:||.:::..|:.:.|.|.|||..|||||.:||||:|||||||||.|||||..|:::|
  Rat   311 AEYAANITKAVFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSN 375

  Fly   356 KQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQPV 420
            :|.:|..:|||:.||||||:|||.||:|||||||||.:.::.|||....||.||.|..:..:.||
  Rat   376 QQRVASVVAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPV 440

  Fly   421 LLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNN 485
            ...|:.:||||:|..|.:|.|||::||.|||.||.|::|||:..:..|||::....||...:|.|
  Rat   441 QEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKN 505

  Fly   486 TVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNPASYEEAPSD 550
            ..|.||...:|. .::..:|::|.|||.||||||:.||    |...|||:|||   ..|:..||.
  Rat   506 AKTSDFWDSLEK-ASNQPVKEVMDTWTSQMGYPVVTVS----GKQNVTQKRFL---LDYKADPSQ 562

  Fly   551 --SAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAVPSEVQ---WIKLNVNQTGYYRVNYEES 610
              ||.||.|::||.| .::|:.|..:| |..:..||.:.:.:.   ::|:|.:..|:||||||..
  Rat   563 PPSALGYTWNIPIKW-TENGNSNITVY-YRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAE 625

  Fly   611 LWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPW------- 668
            .|..:.:.|:::...|..|||...::||||||.|..|.|:..|::|.||..|:||:||
  Rat   626 TWDWIAETLSSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLPWERVISAV 690

  Fly   669 -YVASNKLRSLHRSLMFS---EGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAAC 729
             |:.|          ||.   |.|....||.||.:..:.:.:||. |..:|:...||.|:|..||
  Rat   691 SYIIS----------MFEDDRELYPLIETYFRSQVKPIADSLGWQ-DTGSHITKLLRASVLGFAC 744

  Fly   730 ALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKL 794
            .:|..:.|..||:.|..:|:...:.| .:||.:||.||||.|.::::|:...:.:...:.|.||.
  Rat   745 KMGAGEALGNASQLFEAWLKGNESIP-VNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKE 808

  Fly   795 KLMYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTR 859
            ||:|||:.|::...|..:| :...|.:|:::||.||.::||:.|..|:.:.|.:.:..|..|..|
  Rat   809 KLLYGLASVKDVTLLARYL-EMLKDPNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNR 872

  Fly   860 FGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNEAD 924
            |.:|:|..||::. |...|.:.::|.::|.||:|||.:||||..|.:.:||:|.|||||..|...
  Rat   873 FTINDRYLGRIVT-IAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKS 936

  Fly   925 ITDWLSGTASP 935
            |::|.  |:.|
  Rat   937 ISEWF--TSMP 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	169/397 (43%)
		M1_APN_2	75..518	CDD:189008	190/453 (42%)
		ERAP1_C	593..910	CDD:288671	114/327 (35%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77		2/4 (50%)
		Peptidase_M1	84..474	CDD:279741	169/397 (43%)
		M1_APN_2	92..537	CDD:189008	190/453 (42%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	114/327 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352481
Domainoid	1	1.000	237	1.000	Domainoid score	I2242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68216
Inparanoid	1	1.050	647	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		otm44517
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900