Protein Alignment CG8774 and RNPEP

DIOPT Version :10

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 111/481 - (23%)
• Similarity: 187/481 - (38%)
• Gaps: 101/481 - (20%)

  Fly   178 AGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAI 242
            ||..:....|:.:....|..|||||.||:|..::..:..|.| :.||.:....|......:   .
Human   159 AGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDG-FTAVMSASTWEKRGPNKF---F 219

  Fly   243 FETSVSMSTYLVCIIVSDFASQSTTVKA----------------NGIGEDFSMQAYATSHQINKV 291
            |:....:.:||:.:.:.|..|.....::                ||:.|:|    .||..::
Human   220 FQMCQPIPSYLIALAIGDLVSAEVGPRSRVWAEPCLIDAAKEEYNGVIEEF----LATGEKL--- 277

  Fly   292 EFALEFGQAVTEYYIQYYKVPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTAN 355
                 ||             ||...:.|:..: |.|..|.||: ..:|:....||        |.
Human   278 -----FG-------------PYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPCLL--------AG 315

  Fly   356 KQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQ-----------YKGVNAVHPDWGML 409
            .:|:|..:.|||:|.|||||||...|.:.||||||..|.|           |..:.|. ....:|
Human   316 DRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAA-TGRALL 379

  Fly   410 EQFQIVALQPVLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVG-AEKFEEA 473
            .|...:..:...|...::...|.|    .||:   .::...||||...:..|..||| .::|:..
Human   380 RQHMDITGEENPLNKLRVKIEPGV----DPDD---TYNETPYEKGFCFVSYLAHLVGDQDQFDSF 437

  Fly   474 VTNYLVKHQFNNTVTDDFLTEVEAVVTDLDIKKLML-------TWTEQMGY-PVLNVSKVADGSF 530
            :..|:.:.:|.:.:.||||........:|..|::.:       .|....|: |.|......|...
Human   438 LKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLM 502

  Fly   531 KVTQQRFLSNPASYEEAPSDSAYGY---KW-SVPITWFADDGSENSFIYDYDVDSVGIAVPS--- 588
            |..::  |:...:.||....:....   .| :..:.:|.|...:.|.:...:|..:|...||
Human   503 KPAEE--LAQLWAAEELDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPGNVKKLGDTYPSISN 565

  Fly   589 ------EVQW---IKLNVNQTGYYRV 605
                  .::|   :..|.:|..:::|
Human   566 ARNAELRLRWGQIVLKNDHQEDFWKV 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	91/370 (25%)
		ERAP1_C	592..912	CDD:463368	4/17 (24%)
RNPEP	NP_064601.3	M1_LTA4H	24..484	CDD:341062	91/370 (25%)
		Leuk-A4-hydro_C	530..644	CDD:462686	12/62 (19%)