Protein Alignment CG8774 and RNPEPL1

DIOPT Version :9

• Sequence 1: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 127/536 - (23%)
• Similarity: 208/536 - (38%)
• Gaps: 138/536 - (25%)

  Fly   130 ELEEERQFLII---TLTEELAV---DASITLGIIFGGQMKDKLVGLYSSTYLNEAGATRTISTTK 188
            ||:..:.|.:|   |.|:..|:   |..:|.                        |..:....|:
Human   156 ELQAHQPFQVILRYTSTDAPAIWWLDPELTY------------------------GCAKPFVFTQ 196

  Fly   189 FEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNMQQTESNYLGDYTEAIFETSVS--MST 251
            ......|..|||||.||:|.|::..|..|||   ....|..|.|.|:.:  |.:|...:.  :..
Human   197 GHSVCNRSFFPCFDTPAVKCTYSAVVKAPSG---VQVLMSATRSAYMEE--EGVFHFHMEHPVPA 256

  Fly   252 YLVCIIVSDFASQSTTVKANGIGEDFSMQA------YATSHQINKVEFALEFGQAVTEYYIQYYK 310
            |||.::..|       :|...||....:.|      .|||.....||   ::..|....|
Human   257 YLVALVAGD-------LKPADIGPRSRVWAEPCLLPTATSKLSGAVE---QWLSAAERLY----- 306

  Fly   311 VPYPLTKLDMAAI-PDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIAHQWFGN 374
            .||...:.|:..: |.|...|||: ..:|:..:::|....:        :...:.||:||.||||
Human   307 GPYMWGRYDIVFLPPSFPIVAMEN-PCLTFIISSILESDEF--------LVIDVIHEVAHSWFGN 362

  Fly   375 LVTMKWWNDLWLNEGFARYMQYK-----------------GVNAVHPDWGMLEQFQIVALQPVLL 422
            .||...|.::||:||.|.|.|.:                 .::|:|....:|.:.     .||..
Human   363 AVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGED-----SPVSK 422

  Fly   423 YDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVG-AEKFEEAVTNYLVKHQFNNT 486
            ...||  .|.|    :|..:..:|   :||||...:..|..|.| .::|::.:..|:.|::|.:.
Human   423 LQVKL--EPGV----NPSHLMNLF---TYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSV 478

  Fly   487 VTDD-------FLTEVEAVVTD----LDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQ------ 534
            |..|       |..|::....|    |:.::    |....| |.|....::.|| .:|:
Human   479 VAQDLLDSFLSFFPELKEQSVDCRAGLEFER----WLNATG-PPLAEPDLSQGS-SLTRPVEALF 537

  Fly   535 QRFLSNPASYEEAPSDSAYGYKW-SVPITWFAD---DGS--------ENSFIYDYDVDSVGIAVP 587
            |.:.:.|.....|.:.:....|| :.....|.|   |||        ..|..|...:||:...:
Human   538 QLWTAEPLDQAAASASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEI- 601

  Fly   588 SEVQWIKLNVNQTGYY 603
             .::|::: |.:..||
Human   602 -RIRWLQI-VVRNDYY 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	87/355 (25%)
		M1_APN_2	75..518	CDD:189008	104/431 (24%)
		ERAP1_C	593..910	CDD:288671	3/11 (27%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	103/426 (24%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P15144	326..330		2/3 (67%)
		Leuk-A4-hydro_C	560..673	CDD:401171	14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810