DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8774 and trhde.2

DIOPT Version :9

Sequence 1:	NP_650274.2	Gene:	CG8774 / 41635	FlyBaseID:	FBgn0038136	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	982	Identity:	307/982 - (31%)
Similarity:	499/982 - (50%)	Gaps:	92/982 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVVLSWAVVAFATATVVVAVQ---KAQLERDLRDVQDKIDVFEEWSGESRTRMKR--------ED 62
            ::||.:| ::..|..:|.|:.   ....||...:....:..    :|.|.::.|:        .|
Zfish    38 RLVLGFA-ISILTLIIVTAIAITLSVSFERCAAESSGALAA----NGSSNSKWKQSRDGNISHRD 97

  Fly    63 TTD-------YRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATNQIILHSYLLDITSVY 120
            :.|       .|||..|.|.||:|.....:|..:|:|:..|..:.|.:|..|:|||..|::..|.
Zfish    98 SEDGQQPWRHLRLPATLRPRHYDLRLTVHMENFSFSGEVNIEFECVNSTKLIVLHSDRLELDKVL 162

  Fly   121 VLNREVEKFELEEERQF-------LIITLTEELAVDASITLGIIFGGQMKDKLVGLYSSTY-LNE 177
            |.:...:...:..:|:|       .:|.|..|:....:..:.|.|...::.:|:|.:.|:| ||
Zfish   163 VFSDSKKAGAMRIQRRFHYQPKQVYVIALHREMKPLRTYKINITFTAHIEHELLGFFRSSYMLN- 226

  Fly   178 AGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVSNM--QQTESNYLGDYTE 240
             |..|.::.|:|.||:||:||||||||..||||.:::.|.| ||.::|||  :.|.|:..|..|.
Zfish   227 -GERRFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHES-SYQSLSNMPVEATTSDEDGWVTN 289

  Fly   241 AIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYA--TSHQINKVEFALEFGQAVTE 303
            . |..:..||||.:...|.:| :....|..||:    .::.||  .:.|....::||...:.:.:
Zfish   290 H-FSRTPRMSTYYLAWAVCNF-TYKEAVADNGV----LIRLYARPDAIQSGSGDYALRITKRLLQ 348

  Fly   304 YYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTANKQSIAGTLAHEIA 368
            :|..|:||.|.|.|||:.|:|.....|||:|||..:.|..:|.||..||.:.:..:...:.|||.
Zfish   349 FYQDYFKVKYSLPKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVVVHEIC 413

  Fly   369 HQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQ-FQIVALQPVLLYDAKLSSHPI 432
            |||||:|||..||.|:||.||||.|.:|.|.:.:.|.|.|.:| |....|..|:|.|...|||||
Zfish   414 HQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGLASSHPI 478

  Fly   433 VQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFNNTVTDDFLTEVEA 497
            .|:|....:|..:||.|:|:||.::||||..::|...|:.|:.:||:.|.:.|...||...::..
Zfish   479 SQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSE 543

  Fly   498 VV----TDLDIKKLMLTWTEQMGYPVLNVSK--VADGSFKVTQQRF-------LSNPASYEEAPS 549
            .:    .|::|.::|..||.||||||:.:||  ..|.|..::|:.|       :.||..:.::
Zfish   544 AMQREGKDINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKS-- 606

  Fly   550 DSAYGYKWSVPITWFADDGSE---NSFIY---DYDVDSVGIAVPSEVQWIKLNVNQTGYYRVNYE 608
                 ::|.:|:|....:.|.   .:.|:   ..:...||..|..  .|:..|:|||||:||||:
Zfish   607 -----FQWQIPLTLAVGNASHISTETIIWVTNKSEAHRVGHVVGE--TWLLGNINQTGYFRVNYD 664

  Fly   609 ESLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPWYVASN 673
            ...|.|||||||.:|....:.:|..|::|.|.||.|..|...:||.|.:||:||.:|:||:.||.
Zfish   665 LHNWKLLIQQLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQETEFLPWHAASR 729

  Fly   674 KLRSLHRSLMFSEGYVSYLTYARSLIAGVYEEVGW-TVDADNHLKN------RLRVSILTAACAL 731
            .|..|.:.|..:..:..:..|....:...|.::|| ....|..|.:      .|:..::..||:.
Zfish   730 ALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSLMHSAYQTEELQREVIMLACSF 794

  Fly   732 GVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEKLKL 796
            |...|.:||....|.::.:...|..|::|:|||..|: ....:..|:.::..|.:.|..|||..|
Zfish   795 GNKHCHRQAVSLISDWISSNKNRIPPNVRDIVYCTGV-SLMDEDVWEFIWMKFHSSTAVSEKKVL 858

  Fly   797 MYGLSGVRNSQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWPQLTTRFG 861
            :..|: ..::.:|.:.|...|....:|..||....:.::|.||:|..:.|.::||:|..|.:|:|
Zfish   859 LEALT-CSDNIFLLNRLLNLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKWDILNSRYG 922

  Fly   862 ----LNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLSRNE 922
                :|:    :||:.:|....:..:|.|::.|.  ....|..|.:...|||.::.|::|....:
Zfish   923 EALFMNS----KLISGVTEFLNTEAELNELKEFI--LTSGGESAPAFARAVEIVQANVKWHILFQ 981

  Fly   923 ADITDWL 929
            .....||
Zfish   982 EQFYQWL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8774	NP_650274.2	Peptidase_M1	67..454	CDD:279741	147/399 (37%)
		M1_APN_2	75..518	CDD:189008	165/459 (36%)
		ERAP1_C	593..910	CDD:288671	99/327 (30%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	147/399 (37%)
		M1_APN_2	118..568	CDD:189008	165/458 (36%)
		ERAP1_C	649..968	CDD:288671	98/326 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010